Entity Details

Primary name COPB2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35606
EntryNameCOPB2_HUMAN
FullNameCoatomer subunit beta'
TaxID9606
Evidenceevidence at protein level
Length906
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesCOPB2

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0005198 structural molecule activity
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0006886 intracellular protein transport
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
GO:0006891 intra-Golgi vesicle-mediated transport
GO:0030126 COPI vesicle coat
GO:0030133 transport vesicle
GO:1901998 toxin transport

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic vesicle
Golgi apparatus membrane

Domains

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DomainNameCategoryType
IPR001680 WD40 repeatRepeatRepeat
IPR006692 Coatomer, WD associated regionDomainDomain
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR016453 Coatomer beta' subunit (COPB2)FamilyFamily
IPR020472 G-protein beta WD-40 repeatRepeatRepeat
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
617800 OMIMMicrocephaly 19, primary, autosomal recessive (MCPH19)A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age, sex and ethnically matched mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. MCPH19 affected individuals manifest severe developmental delay, failure to thrive, cortical blindness, and spasticity. Brain imaging show a simplified gyral pattern, thin corpus callosum, slight ventricular dilation, and delayed myelination. The disease may be caused by variants affecting the gene represented in this entry.

Interactions

38 interactions

InteractorPartnerSourcesPublicationsLink
COPB2_HUMANNFKB1_HUMANBioGRID, IntAct, MINT14743216 21988832 25609649 27609421 details
COPB2_HUMANTMEDA_HUMANBioGRID, UniProt9472029 9751720 details
COPB2_HUMANCOPG1_HUMANBioGRID, IntAct10921873 14729954 22863883 22939629 26344197 28514442 9751720 details
COPB2_HUMANMFHA1_HUMANBioGRID, IntAct29513927 details
COPB2_HUMANRGS4_HUMANBioGRID, HPRD10982407 details
COPB2_HUMANCOPA_HUMANBioGRID, HPRD10921873 14729954 22863883 22939629 26344197 8537409 8940050 9482852 9751720 details
COPB2_HUMANCOPE_HUMANBioGRID10921873 22939629 9482852 details
COPB2_HUMANCOPB_HUMANBioGRID10921873 14729954 22939629 26344197 8940050 9482852 9751720 details
COPB2_HUMANRGS2_HUMANBioGRID, HPRD10982407 details
COPB2_HUMANWBP2_HUMANBioGRID27578003 details
COPB2_HUMANMCPH1_HUMANBioGRID29150431 details
COPB2_HUMANSUMO2_HUMANBioGRID32786267 details
COPB2_HUMANMSRA_HUMANBioGRID32456285 details
COPB2_HUMANBRF2_HUMANIntAct17353931 details
COPB2_HUMANMYC_HUMANBioGRID, IntAct17353931 29467282 details
COPB2_HUMANCRCM_HUMANIntAct17353931 details
COPB2_HUMANTR10D_HUMANIntAct17353931 details
COPB2_HUMANTNIK_HUMANIntAct17353931 details
COPB2_HUMANMAGA6_HUMANIntAct17353931 details
COPB2_HUMANGIPC1_HUMANIntAct17353931 details
COPB2_HUMANRTCA_HUMANIntAct17353931 details
COPB2_HUMANCDK4_HUMANIntAct17353931 details
COPB2_HUMANAAKB1_HUMANIntAct17353931 details
COPB2_HUMANCIAO1_HUMANIntAct17353931 details
COPB2_HUMANGSTK1_HUMANIntAct17353931 details
COPB2_HUMANKPCE_HUMANBioGRID, HPRD11897493 9360998 details
COPB2_HUMANHDAC5_HUMANBioGRID21081666 details
COPB2_HUMANCOPB2_HUMANBioGRID14729954 9482852 details
COPB2_HUMANCOPG2_HUMANBioGRID14729954 22939629 details
COPB2_HUMANCOPD_HUMANBioGRID, HPRD14729954 22939629 26344197 8940050 details
COPB2_HUMANLMAN1_HUMANBioGRID22337587 details
COPB2_HUMANRN126_HUMANBioGRID26508657 details
COPB2_HUMANF210A_HUMANBioGRID26472760 details
COPB2_HUMANMYO6_HUMANBioGRID26950368 details
COPB2_HUMANGORAB_HUMANBioGRID30631079 details
COPB2_HUMANSCYL1_HUMANBioGRID30631079 details
COPB2_HUMANISG15_HUMANBioGRID33024031 details
COPB2_HUMANSAC1_HUMANHPRD14527956 details