Entity Details

Primary name GRP75_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP38646
EntryNameGRP75_HUMAN
FullNameStress-70 protein, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length679
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesHSPA9

GO terms

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GOName
GO:0001401 SAM complex
GO:0003723 RNA binding
GO:0005524 ATP binding
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005925 focal adhesion
GO:0006611 protein export from nucleus
GO:0007007 inner mitochondrial membrane organization
GO:0016226 iron-sulfur cluster assembly
GO:0016887 ATP hydrolysis activity
GO:0030218 erythrocyte differentiation
GO:0031072 heat shock protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0034620 cellular response to unfolded protein
GO:0035722 interleukin-12-mediated signaling pathway
GO:0042026 protein refolding
GO:0042645 mitochondrial nucleoid
GO:0043066 negative regulation of apoptotic process
GO:0044183 protein folding chaperone
GO:0045646 regulation of erythrocyte differentiation
GO:0045647 negative regulation of erythrocyte differentiation
GO:0051082 unfolded protein binding
GO:0051085 chaperone cofactor-dependent protein refolding
GO:0051787 misfolded protein binding
GO:0070062 extracellular exosome
GO:0140275 MIB complex
GO:1902037 negative regulation of hematopoietic stem cell differentiation
GO:1903707 negative regulation of hemopoiesis

Subcellular Location

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Subcellular Location
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR012725 Chaperone DnaKFamilyFamily
IPR013126 Heat shock protein 70 familyFamilyFamily
IPR018181 Heat shock protein 70, conserved siteSiteConserved site
IPR029047 Heat shock protein 70kD, peptide-binding domain superfamilyFamilyHomologous superfamily
IPR029048 Heat shock protein 70kD, C-terminal domain superfamilyFamilyHomologous superfamily
IPR043129 ATPase, nucleotide binding domainFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
182170 OMIMAnemia, sideroblastic, 4 (SIDBA4)A form of sideroblastic anemia, a bone marrow disorder defined by the presence of pathologic iron deposits in erythroblast mitochondria. Sideroblastic anemia is characterized by anemia of varying severity, hypochromic peripheral erythrocytes, systemic iron overload secondary to chronic ineffective erythropoiesis, and the presence of bone marrow ringed sideroblasts. Sideroblasts are characterized by iron-loaded mitochondria clustered around the nucleus. SIDBA4 has been reported to be inherited as an autosomal recessive disease, with a pseudodominant pattern of inheritance in some families. The disease is caused by variants affecting the gene represented in this entry.
616854 OMIMEven-plus syndrome (EVPLS)An autosomal recessive syndrome characterized by epiphyseal and vertebral dysplasia, prenatal-onset short stature, a distinct craniofacial phenotype with microtia, a flat facial profile with flat nose and triangular nares, cardiac malformations, and additional findings such as anal atresia, hypodontia, aplasia cutis, and others. The disease is caused by variants affecting the gene represented in this entry.

Interactions

100 interactions

InteractorPartnerSourcesPublicationsLink
GRP75_HUMANEGFR_HUMANBioGRID, IntAct15657067 20029029 24189400 28065597 31980649 details
GRP75_HUMANP53_HUMANBioGRID, HPRD, IntAct, MINT11900485 17184779 20153329 22340593 22366412 22726440 23443559 25144556 31570706 details
GRP75_HUMANCDN2A_HUMANBioGRID, IntAct17955473 19049976 details
GRP75_HUMANNELFB_HUMANBioGRID, IntAct20195357 details
GRP75_HUMANXPO1_HUMANBioGRID, IntAct21988832 details
GRP75_HUMANLSM8_HUMANBioGRID, IntAct21988832 details
GRP75_HUMANLTOR5_HUMANBioGRID, IntAct23414517 details
GRP75_HUMANDNLZ_HUMANBioGRID, IntAct22162012 28514442 details
GRP75_HUMANTCTP_HUMANMINT27607350 details
GRP75_HUMANERBB2_HUMANBioGRID, IntAct31980649 details
GRP75_HUMANMVD1_HUMANBioGRID, HPRD12646231 details
GRP75_HUMANFGF1_HUMANBioGRID, HPRD10510314 details
GRP75_HUMANTIM14_HUMANBioGRID20053669 22544056 details
GRP75_HUMANDNJA3_HUMANBioGRID22544056 26344197 33957083 details
GRP75_HUMANA4_HUMANBioGRID21832049 details
GRP75_HUMANHPBP1_HUMANBioGRID, HPRD19659607 details
GRP75_HUMANARF_HUMANBioGRID17955473 19049976 details
GRP75_HUMANYKT6_HUMANBioGRID25416956 details
GRP75_HUMANSUMO2_HUMANBioGRID19394292 details
GRP75_HUMANTIM44_HUMANBioGRID12677068 26344197 33957083 details
GRP75_HUMANUBX2A_HUMANBioGRID26634371 details
GRP75_HUMANCHIP_HUMANBioGRID30107089 details
GRP75_HUMANSHPS1_HUMANBioGRID19299420 details
GRP75_HUMANPTN11_HUMANBioGRID19299420 details
GRP75_HUMANMATK_HUMANBioGRID19299420 details
GRP75_HUMANSPT6H_HUMANBioGRID19299420 details
GRP75_HUMANPTPRF_HUMANBioGRID25458010 details
GRP75_HUMANERPG3_HUMANBioGRID31722399 details
GRP75_HUMANERCC6_HUMANBioGRID31722399 details
GRP75_HUMANOGT1_HUMANBioGRID32994395 details
GRP75_HUMANM3K8_HUMANIntAct14743216 details
GRP75_HUMANREL_HUMANIntAct14743216 details
GRP75_HUMANIKBA_HUMANIntAct14743216 details
GRP75_HUMANIKBB_HUMANIntAct14743216 details
GRP75_HUMANIKBE_HUMANIntAct14743216 details
GRP75_HUMANIKKA_HUMANIntAct14743216 details
GRP75_HUMANIKKB_HUMANIntAct14743216 details
GRP75_HUMANIKKE_HUMANIntAct14743216 details
GRP75_HUMANNEMO_HUMANIntAct14743216 details
GRP75_HUMANTANK_HUMANIntAct14743216 details
GRP75_HUMANM3K1_HUMANIntAct14743216 details
GRP75_HUMANNFKB2_HUMANIntAct14743216 details
GRP75_HUMANM3K14_HUMANIntAct14743216 details
GRP75_HUMANTF65_HUMANIntAct14743216 details
GRP75_HUMANRELB_HUMANIntAct14743216 details
GRP75_HUMANRIPK1_HUMANIntAct14743216 details
GRP75_HUMANRIPK3_HUMANIntAct14743216 details
GRP75_HUMANTAB1_HUMANIntAct14743216 details
GRP75_HUMANTAB2_HUMANIntAct14743216 details
GRP75_HUMANM3K7_HUMANIntAct14743216 details
GRP75_HUMANTBK1_HUMANIntAct14743216 details
GRP75_HUMANTNR1A_HUMANIntAct14743216 details
GRP75_HUMANTNR1B_HUMANIntAct14743216 details
GRP75_HUMANTRAF1_HUMANIntAct14743216 details
GRP75_HUMANTRAF2_HUMANIntAct14743216 details
GRP75_HUMANTRAF6_HUMANIntAct14743216 details
GRP75_HUMANM3K3_HUMANIntAct14743216 details
GRP75_HUMANFBX33_HUMANMINT16797541 details
GRP75_HUMAN1433Z_HUMANMINT15161933 details
GRP75_HUMANOPTN_HUMANIntAct20195357 details
GRP75_HUMANP73_HUMANBioGRID, IntAct22340593 details
GRP75_HUMANCALX_HUMANMINT22045338 details
GRP75_HUMANITPR1_HUMANIntAct24947355 details
GRP75_HUMANHSC20_HUMANBioGRID, DIP, IntAct24606901 28380382 details
GRP75_HUMANCH60_HUMANBioGRID, IntAct22939629 30021884 30107089 details
GRP75_HUMANOSMR_HUMANMINT32807793 details
GRP75_HUMANHDAC5_HUMANBioGRID21081666 details
GRP75_HUMANSIR1_HUMANBioGRID19343720 details
GRP75_HUMANMIC10_HUMANBioGRID22114354 details
GRP75_HUMANBAP1_HUMANBioGRID20805357 details
GRP75_HUMANRN146_HUMANBioGRID21825151 details
GRP75_HUMANPRKN_HUMANBioGRID21640711 24244333 32929329 details
GRP75_HUMANCADH1_HUMANBioGRID16212417 details
GRP75_HUMANC1QBP_HUMANBioGRID22904065 details
GRP75_HUMANMT21A_HUMANBioGRID23349634 details
GRP75_HUMANMT21D_HUMANBioGRID23349634 details
GRP75_HUMANZSWM7_HUMANBioGRID21965664 details
GRP75_HUMANGRSF1_HUMANBioGRID23473034 details
GRP75_HUMANSPRTN_HUMANBioGRID23254330 details
GRP75_HUMANGPX7_HUMANBioGRID23123197 details
GRP75_HUMANGAN_HUMANBioGRID26460568 details
GRP75_HUMANPRDM1_HUMANBioGRID26823144 details
GRP75_HUMANU2AF2_HUMANBioGRID26641092 details
GRP75_HUMANAIFM1_HUMANBioGRID27218139 34079125 details
GRP75_HUMANACK1_HUMANBioGRID28739485 details
GRP75_HUMANRARA_HUMANBioGRID22022577 details
GRP75_HUMANRXRA_HUMANBioGRID22022577 details
GRP75_HUMANRARB_HUMANBioGRID22022577 details
GRP75_HUMANFGF11_HUMANBioGRID28027390 details
GRP75_HUMANTGM2_HUMANBioGRID30590033 details
GRP75_HUMANHYPK_HUMANBioGRID27067261 details
GRP75_HUMANBIRC3_HUMANBioGRID30948266 details
GRP75_HUMANSOX2_HUMANBioGRID21280222 details
GRP75_HUMANANM8_HUMANBioGRID18320585 details
GRP75_HUMANPARK7_HUMANBioGRID31767755 details
GRP75_HUMANITPR3_HUMANBioGRID31767755 details
GRP75_HUMANDTNA_HUMANBioGRID20111909 details
GRP75_HUMANEIF3H_HUMANBioGRID32269044 details
GRP75_HUMANENPL_HUMANHPRD12470827 details
GRP75_HUMANSUMO4_HUMANHPRD16236267 details