Entity Details

Primary name TTPA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49638
EntryNameTTPA_HUMAN
FullNameAlpha-tocopherol transfer protein
TaxID9606
Evidenceevidence at protein level
Length278
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesTTPA

GO terms

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GOName
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005770 late endosome
GO:0005829 cytosol
GO:0006629 lipid metabolic process
GO:0007584 response to nutrient
GO:0008431 vitamin E binding
GO:0009268 response to pH
GO:0032502 developmental process
GO:0042360 vitamin E metabolic process
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
GO:0051180 vitamin transport
GO:0051452 intracellular pH reduction
GO:0060548 negative regulation of cell death
GO:0120009 intermembrane lipid transfer
GO:0120013 lipid transfer activity
GO:1902936 phosphatidylinositol bisphosphate binding

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001251 CRAL-TRIO lipid binding domainDomainDomain
IPR011074 CRAL/TRIO, N-terminal domainDomainDomain
IPR036273 CRAL/TRIO, N-terminal domain superfamilyFamilyHomologous superfamily
IPR036865 CRAL-TRIO lipid binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
277460 OMIMAtaxia with isolated vitamin E deficiency (AVED)An autosomal recessive disease characterized by undetectable or markedly reduced plasma levels of vitamin E, spinocerebellar degeneration, ataxia, areflexia and proprioception loss. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00163 Vitamin EDrugbanksmall molecule
DB02080 1-{2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy}-4-(1,1,3,3-Tetramethylbutyl)BenzeneDrugbanksmall molecule
DB11251 TocopherolSwissprotsmall molecule
DB11635 TocofersolanDrugbanksmall molecule
DB14001 alpha-Tocopherol succinateDrugbanksmall molecule
DB14002 D-alpha-Tocopherol acetateDrugbanksmall molecule
DB14003 alpha-Tocopherol acetateSwissprotsmall molecule

Interactions

48 interactions

InteractorPartnerSourcesPublicationsLink
TTPA_HUMANF1142_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANRPRM_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANMAL2_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANNDUA7_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANPYRD_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANJOS2_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANREEP2_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANDHB11_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANBIRC7_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANARFP2_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANKRA23_HUMANBioGRID32296183 details
TTPA_HUMANKR122_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANAPOA5_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANAPOC2_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANFM25A_HUMANBioGRID32296183 details
TTPA_HUMANFADS6_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANFM25C_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANCOQ3_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANFKBP7_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANARM12_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANCISD2_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANCKLF5_HUMANBioGRID, IntAct25416956 32296183 details
TTPA_HUMANSNG3_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANSAR1A_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANPEX12_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANATRAP_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANFM25G_HUMANBioGRID32296183 details
TTPA_HUMANKR123_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANKRA24_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANGOGA2_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANDG2L6_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANLEUTX_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANSCAM5_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANA4_HUMANBioGRID21832049 details
TTPA_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANRDHE2_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANFGF14_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANTHAP4_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANKR107_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANSCAM1_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANCKLF4_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANTPD52_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANNT2NC_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANMRM1_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANSHLB1_HUMANIntAct32814053 details
TTPA_HUMANNT2NA_HUMANBioGRID32296183 details
TTPA_HUMANS35E3_HUMANBioGRID, IntAct32296183 details
TTPA_HUMANMGMT_HUMANBioGRID16226712 details