Entity Details

Primary name SBP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13228
EntryNameSBP1_HUMAN
FullNameMethanethiol oxidase
TaxID9606
Evidenceevidence at protein level
Length472
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesSELENBP1

GO terms

Show/Hide Table
GOName
GO:0001650 fibrillar center
GO:0005615 extracellular space
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0008430 selenium binding
GO:0015031 protein transport
GO:0016020 membrane
GO:0018549 methanethiol oxidase activity
GO:0070062 extracellular exosome

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Membrane
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR008826 Selenium-binding proteinFamilyFamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
618148 OMIMExtraoral halitosis due to methanethiol oxidase deficiency (EHMTO)An autosomal recessive malodor condition characterized by extraoral blood-borne halitosis resulting from the accumulation of sulfur-containing metabolites. In extraoral blood-borne halitosis, malodorant compounds are carried to the lungs, where they enter the breath. Affected individuals have a cabbage-like breath odor, high levels of methanethiol and dimethylsulfide in oral and nasal breath, and elevated urinary excretion of dimethylsulfoxide in the absence of intake of dimethylsulfide-containing food or use of sulfur-containing medication, lower-gastrointestinal problems, and known metabolic defects, such as methionine adenosyltransferase deficiency and tyrosinemia. The disease is caused by variants affecting the gene represented in this entry.