Entity Details

Primary name KGP2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13237
EntryNameKGP2_HUMAN
FullNamecGMP-dependent protein kinase 2
TaxID9606
Evidenceevidence at protein level
Length762
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesPRKG2

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0004672 protein kinase activity
GO:0004692 cGMP-dependent protein kinase activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0016324 apical plasma membrane
GO:0030553 cGMP binding
GO:0031965 nuclear membrane
GO:0036289 peptidyl-serine autophosphorylation
GO:0042802 identical protein binding
GO:0046146 tetrahydrobiopterin metabolic process
GO:0072659 protein localization to plasma membrane
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:2001226 negative regulation of chloride transport

Subcellular Location

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Subcellular Location
Apical cell membrane

Domains

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DomainNameCategoryType
IPR000595 Cyclic nucleotide-binding domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR002374 cGMP-dependent kinaseFamilyFamily
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR014710 RmlC-like jelly roll foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR018488 Cyclic nucleotide-binding, conserved siteSiteConserved site
IPR018490 Cyclic nucleotide-binding-likeFamilyHomologous superfamily
IPR035014 cGMP-dependent protein kinase, catalytic domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule