Entity Details

Primary name AGT
Entity type gene
Source Source Link

Details

PrimaryID183
RefseqGeneNG_008836
SymbolAGT
Nameangiotensinogen
Chromosome1
Location1q42.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-11-02
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsANGT_HUMAN

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001558 regulation of cell growth
GO:0001819 positive regulation of cytokine production
GO:0001822 kidney development
GO:0001974 blood vessel remodeling
GO:0002016 regulation of blood volume by renin-angiotensin
GO:0002018 renin-angiotensin regulation of aldosterone production
GO:0002019 regulation of renal output by angiotensin
GO:0002034 maintenance of blood vessel diameter homeostasis by renin-angiotensin
GO:0003014 renal system process
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005179 hormone activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007199 G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007263 nitric oxide mediated signal transduction
GO:0007267 cell-cell signaling
GO:0008083 growth factor activity
GO:0008217 regulation of blood pressure
GO:0010536 positive regulation of activation of Janus kinase activity
GO:0010595 positive regulation of endothelial cell migration
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0010629 negative regulation of gene expression
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0010873 positive regulation of cholesterol esterification
GO:0010951 negative regulation of endopeptidase activity
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014873 response to muscle activity involved in regulation of muscle adaptation
GO:0016176 superoxide-generating NADPH oxidase activator activity
GO:0017080 sodium channel regulator activity
GO:0019222 regulation of metabolic process
GO:0019229 regulation of vasoconstriction
GO:0031702 type 1 angiotensin receptor binding
GO:0031703 type 2 angiotensin receptor binding
GO:0032270 positive regulation of cellular protein metabolic process
GO:0033864 positive regulation of NAD(P)H oxidase activity
GO:0034374 low-density lipoprotein particle remodeling
GO:0035813 regulation of renal sodium excretion
GO:0038166 angiotensin-activated signaling pathway
GO:0042127 regulation of cell population proliferation
GO:0042310 vasoconstriction
GO:0043407 negative regulation of MAP kinase activity
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048018 receptor ligand activity
GO:0048146 positive regulation of fibroblast proliferation
GO:0050729 positive regulation of inflammatory response
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0072562 blood microparticle
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:1901201 regulation of extracellular matrix assembly
GO:1902632 positive regulation of membrane hyperpolarization
GO:1903598 positive regulation of gap junction assembly
GO:1903779 regulation of cardiac conduction
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000650 negative regulation of sodium ion transmembrane transporter activity
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway

Diseases

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Disease IDSourceNameDescription
267430 OMIMRenal tubular dysgenesis (RTD)Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). The disease is caused by variants affecting the gene represented in this entry.
145500 OMIMEssential hypertension (EHT)A condition in which blood pressure is consistently higher than normal with no identifiable cause. Disease susceptibility is associated with variants affecting the gene represented in this entry.