Entity Details

Primary name DYHC1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14204
EntryNameDYHC1_HUMAN
FullNameCytoplasmic dynein 1 heavy chain 1
TaxID9606
Evidenceevidence at protein level
Length4646
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesDYNC1H1

GO terms

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GOName
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0003723 RNA binding
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005868 cytoplasmic dynein complex
GO:0005874 microtubule
GO:0005881 cytoplasmic microtubule
GO:0005938 cell cortex
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0007018 microtubule-based movement
GO:0007052 mitotic spindle organization
GO:0007097 nuclear migration
GO:0008090 retrograde axonal transport
GO:0008569 minus-end-directed microtubule motor activity
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0016020 membrane
GO:0019058 viral life cycle
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030286 dynein complex
GO:0031122 cytoplasmic microtubule organization
GO:0032388 positive regulation of intracellular transport
GO:0033962 P-body assembly
GO:0034063 stress granule assembly
GO:0035578 azurophil granule lumen
GO:0035973 aggrephagy
GO:0043312 neutrophil degranulation
GO:0045505 dynein intermediate chain binding
GO:0051293 establishment of spindle localization
GO:0051301 cell division
GO:0051959 dynein light intermediate chain binding
GO:0060236 regulation of mitotic spindle organization
GO:0070062 extracellular exosome
GO:0072382 minus-end-directed vesicle transport along microtubule
GO:0090235 regulation of metaphase plate congression
GO:0097711 ciliary basal body-plasma membrane docking
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1904115 axon cytoplasm
GO:1905832 positive regulation of spindle assembly

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR003593 AAA+ ATPase domainDomainDomain
IPR004273 Dynein heavy chain region D6 P-loop domainDomainDomain
IPR013594 Dynein heavy chain, tailDomainDomain
IPR013602 Dynein heavy chain, linkerDomainDomain
IPR024317 Dynein heavy chain, AAA module D4DomainDomain
IPR024743 Dynein heavy chain, coiled coil stalkDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR035699 Dynein heavy chain, hydrolytic ATP-binding dynein motor regionDomainDomain
IPR035706 Dynein heavy chain, ATP-binding dynein motor regionDomainDomain
IPR041228 Dynein heavy chain, C-terminal domainDomainDomain
IPR041466 Dynein heavy chain, AAA 5 extension domainDomainDomain
IPR041658 Dynein heavy chain AAA lid domainDomainDomain
IPR042219 Dynein heavy chain AAA lid domain superfamilyFamilyHomologous superfamily
IPR042222 Dynein heavy chain, domain 2, N-terminalFamilyHomologous superfamily
IPR042228 Dynein heavy chain, linker, subdomain 3FamilyHomologous superfamily
IPR043157 Dynein heavy chain, AAA1 domain, small subdomainFamilyHomologous superfamily
IPR043160 Dynein heavy chain, C-terminal domain, barrel regionFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
158600 OMIMSpinal muscular atrophy, lower extremity-predominant 1, autosomal dominant (SMALED1)A form of spinal muscular atrophy, a neuromuscular disorder characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. SMALED1 is characterized by muscle weakness predominantly affecting the proximal lower extremities. The disease is caused by variants affecting the gene represented in this entry.
614563 OMIMMental retardation, autosomal dominant 13 (MRD13)A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD13 is associated with variable neuronal migration defects and mild dysmorphic features. Some patients may also show signs of peripheral neuropathy, such as abnormal gait and hyporeflexia. The disease is caused by variants affecting the gene represented in this entry.
614228 OMIMCharcot-Marie-Tooth disease 2O (CMT2O)An axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. The disease is caused by variants affecting the gene represented in this entry.

Interactions

109 interactions

InteractorPartnerSourcesPublicationsLink
DYHC1_HUMANDISC1_HUMANBioGRID, IntAct17043677 31413325 details
DYHC1_HUMANPSN2_HUMANBioGRID, IntAct21163940 details
DYHC1_HUMANDYHC1_HUMANMINT21723285 details
DYHC1_HUMANEGFR_HUMANBioGRID, IntAct20029029 31980649 details
DYHC1_HUMANZNF16_HUMANUniProt21874239 details
DYHC1_HUMANHD_HUMANDIP, IntAct17500595 17548833 32814053 details
DYHC1_HUMANSYUA_HUMANBioGRID, IntAct17893145 26496610 details
DYHC1_HUMANLIS1_HUMANBioGRID, IntAct11889140 12885786 18784752 19622634 26344197 26496610 27173435 34079125 unassigned1312 details
DYHC1_HUMANHNRPQ_HUMANBioGRID, IntAct26496610 32814053 details
DYHC1_HUMANMTR1B_HUMANBioGRID, IntAct26514267 details
DYHC1_HUMANDUX4_HUMANBioGRID, IntAct26816005 details
DYHC1_HUMANKTNB1_HUMANBioGRID, IntAct16203747 26929214 details
DYHC1_HUMANTNIK_HUMANBioGRID, IntAct17043677 31413325 details
DYHC1_HUMANRPAB1_HUMANIntAct32814053 details
DYHC1_HUMANOTX2_HUMANIntAct32814053 details
DYHC1_HUMANNTF3_HUMANIntAct32814053 details
DYHC1_HUMANNGN1_HUMANIntAct32814053 details
DYHC1_HUMANMYPT2_HUMANIntAct32814053 details
DYHC1_HUMANM3K5_HUMANIntAct32814053 details
DYHC1_HUMANIL16_HUMANIntAct32814053 details
DYHC1_HUMANGA45A_HUMANIntAct32814053 details
DYHC1_HUMANCATH_HUMANIntAct32814053 details
DYHC1_HUMANCRBB3_HUMANIntAct32814053 details
DYHC1_HUMANCOF2_HUMANIntAct32814053 details
DYHC1_HUMANCDK8_HUMANIntAct32814053 details
DYHC1_HUMANASPH_HUMANIntAct32814053 details
DYHC1_HUMANLEG9C_HUMANIntAct32814053 details
DYHC1_HUMANSPT46_HUMANIntAct32814053 details
DYHC1_HUMANTMPS6_HUMANIntAct32814053 details
DYHC1_HUMANPBIR3_HUMANIntAct32814053 details
DYHC1_HUMANATP23_HUMANIntAct32814053 details
DYHC1_HUMANZHX1R_HUMANIntAct32814053 details
DYHC1_HUMANBEX2_HUMANIntAct32814053 details
DYHC1_HUMANDCNL5_HUMANIntAct32814053 details
DYHC1_HUMANPRAM_HUMANIntAct32814053 details
DYHC1_HUMANTMTC1_HUMANIntAct32814053 details
DYHC1_HUMANFA2H_HUMANIntAct32814053 details
DYHC1_HUMANRTP4_HUMANIntAct32814053 details
DYHC1_HUMANTEX12_HUMANIntAct32814053 details
DYHC1_HUMANWBP1L_HUMANIntAct32814053 details
DYHC1_HUMANSCAPE_HUMANIntAct32814053 details
DYHC1_HUMANARFG3_HUMANIntAct32814053 details
DYHC1_HUMANDUS10_HUMANIntAct32814053 details
DYHC1_HUMANWDR5_HUMANIntAct32814053 details
DYHC1_HUMANWWP2_HUMANIntAct32814053 details
DYHC1_HUMANTI17B_HUMANIntAct32814053 details
DYHC1_HUMANBZW1_HUMANIntAct32814053 details
DYHC1_HUMANBAG3_HUMANIntAct32814053 details
DYHC1_HUMANEI2BE_HUMANIntAct32814053 details
DYHC1_HUMANTELT_HUMANIntAct32814053 details
DYHC1_HUMANRXRG_HUMANIntAct32814053 details
DYHC1_HUMANMK11_HUMANIntAct32814053 details
DYHC1_HUMANKTNA1_HUMANBioGRID16203747 details
DYHC1_HUMANBRCA1_HUMANBioGRID22990118 details
DYHC1_HUMANSMAD2_HUMANBioGRID, HPRD15231748 details
DYHC1_HUMANTET5A_HUMANBioGRID15231748 details
DYHC1_HUMAN1433T_HUMANBioGRID15161933 details
DYHC1_HUMANKPCD_HUMANBioGRID20395553 details
DYHC1_HUMANRHBD2_HUMANBioGRID32296183 details
DYHC1_HUMANCOX20_HUMANBioGRID32296183 details
DYHC1_HUMANSUMO2_HUMANBioGRID32786267 details
DYHC1_HUMANNEMO_HUMANIntAct14743216 details
DYHC1_HUMANTRAF6_HUMANIntAct17353931 details
DYHC1_HUMANGBRL2_HUMANIntAct17353931 details
DYHC1_HUMANPHLA3_HUMANIntAct17353931 details
DYHC1_HUMANPP4C_HUMANIntAct17353931 details
DYHC1_HUMANMAGD1_HUMANIntAct17353931 details
DYHC1_HUMANPHB2_HUMANIntAct17353931 details
DYHC1_HUMANNDKB_HUMANBioGRID, IntAct17353931 details
DYHC1_HUMAN1433Z_HUMANMINT15161933 details
DYHC1_HUMANMAX_HUMANBioGRID, IntAct20195357 22939629 details
DYHC1_HUMANEF1D_HUMANIntAct20195357 details
DYHC1_HUMANCDC5L_HUMANBioGRID, MINT11101529 20467437 details
DYHC1_HUMANNF1_HUMANMINT23583712 details
DYHC1_HUMANDC1I2_HUMANBioGRID, IntAct, MINT22863883 24986880 26344197 26496610 28514442 28718761 34079125 details
DYHC1_HUMANDYL1_HUMANBioGRID, HPRD, IntAct14760703 26496610 details
DYHC1_HUMANDCTN4_HUMANBioGRID, IntAct26496610 28718761 details
DYHC1_HUMANDC1L1_HUMANBioGRID, IntAct22863883 22939629 26344197 26496610 28514442 28718761 details
DYHC1_HUMANDC1L2_HUMANBioGRID, IntAct22863883 22939629 26344197 26496610 28718761 details
DYHC1_HUMANDLRB1_HUMANBioGRID, IntAct22939629 26496610 28718761 details
DYHC1_HUMANDCTN1_HUMANBioGRID, IntAct14600259 22939629 22956769 26344197 26496610 26638075 34079125 details
DYHC1_HUMANNIN_HUMANBioGRID, IntAct26638075 28718761 details
DYHC1_HUMANNINL_HUMANBioGRID, IntAct26485645 26638075 28718761 details
DYHC1_HUMANDYLT1_HUMANBioGRID, IntAct22939629 26344197 26638075 27173435 28718761 unassigned1312 details
DYHC1_HUMANDC1I1_HUMANBioGRID, IntAct22956769 28514442 28718761 details
DYHC1_HUMANLRRK2_HUMANBioGRID, IntAct19826009 31046837 details
DYHC1_HUMANFMR1_HUMANIntAct31413325 details
DYHC1_HUMANBICD2_HUMANBioGRID, IntAct11483508 22956769 25512093 28718761 details
DYHC1_HUMANNDEL1_HUMANBioGRID, HPRD11163259 11163260 14970193 18784752 details
DYHC1_HUMANEPB41_HUMANBioGRID10189366 details
DYHC1_HUMANCSK2B_HUMANBioGRID21486957 details
DYHC1_HUMANELP1_HUMANBioGRID18303054 details
DYHC1_HUMANMT21A_HUMANBioGRID23349634 details
DYHC1_HUMANMT21C_HUMANBioGRID23349634 details
DYHC1_HUMANITA4_HUMANBioGRID22623428 details
DYHC1_HUMANSPRTN_HUMANBioGRID23254330 details
DYHC1_HUMANTRI58_HUMANBioGRID25241935 details
DYHC1_HUMANHDAC6_HUMANBioGRID25342804 details
DYHC1_HUMANRUFY1_HUMANBioGRID23144738 details
DYHC1_HUMANNUMA1_HUMANBioGRID26195665 details
DYHC1_HUMANATOH1_HUMANBioGRID27542412 details
DYHC1_HUMANATX3_HUMANBioGRID28180282 30455355 details
DYHC1_HUMANRAE1L_HUMANBioGRID29293652 details
DYHC1_HUMANUBP11_HUMANBioGRID29293652 details
DYHC1_HUMANDAPLE_HUMANBioGRID28718761 details
DYHC1_HUMANGRDN_HUMANBioGRID28718761 details
DYHC1_HUMANHOOK3_HUMANBioGRID28718761 details
DYHC1_HUMANISG15_HUMANBioGRID33024031 details
DYHC1_HUMAN1433G_HUMANHPRD15324660 details