Entity Details

Primary name U5S1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15029
EntryNameU5S1_HUMAN
FullName116 kDa U5 small nuclear ribonucleoprotein component
TaxID9606
Evidenceevidence at protein level
Length972
SequenceStatuscomplete
DateCreated2001-09-26
DateModified2021-06-02

Ontological Relatives

GenesEFTUD2

GO terms

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GOName
GO:0000398 mRNA splicing, via spliceosome
GO:0003723 RNA binding
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0015030 Cajal body
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0030623 U5 snRNA binding
GO:0035690 cellular response to drug
GO:0042220 response to cocaine
GO:0043231 intracellular membrane-bounded organelle
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071005 U2-type precatalytic spliceosome
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome
GO:1990904 ribonucleoprotein complex

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000640 Elongation factor EFG, domain V-likeDomainDomain
IPR000795 Translational (tr)-type GTP-binding domainDomainDomain
IPR004161 Translation elongation factor EFTu-like, domain 2DomainDomain
IPR005225 Small GTP-binding protein domainDomainDomain
IPR005517 Translation elongation factor EFG/EF2, domain IVDomainDomain
IPR009000 Translation protein, beta-barrel domain superfamilyFamilyHomologous superfamily
IPR014721 Ribosomal protein S5 domain 2-type fold, subgroupFamilyHomologous superfamily
IPR020568 Ribosomal protein S5 domain 2-type foldFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR031950 116kDa U5 small nuclear ribonucleoprotein component, N-terminalDomainDomain
IPR035647 EF-G domain III/V-likeFamilyHomologous superfamily
IPR035655 116kDa U5 small nuclear ribonucleoprotein component, C-terminalDomainDomain
IPR041095 Elongation Factor G, domain IIDomainDomain
IPR044121 Snu114, GTP-binding domainDomainDomain

Diseases

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Disease IDSourceNameDescription
610536 OMIMMandibulofacial dysostosis with microcephaly (MFDM)A rare syndrome characterized by progressive microcephaly, midface and malar hypoplasia, micrognathia, microtia, dysplastic ears, preauricular skin tags, significant developmental delay, and speech delay. Many patients have major sequelae, including choanal atresia that results in respiratory difficulties, conductive hearing loss, and cleft palate. The disease is caused by variants affecting the gene represented in this entry.

Interactions

53 interactions

InteractorPartnerSourcesPublicationsLink
U5S1_HUMANSNR40_HUMANBioGRID, IntAct, UniProt16723661 17353931 26186194 26344197 28514442 28515276 9774689 details
U5S1_HUMANPRP8_HUMANBioGRID, IntAct, UniProt16723661 17317632 22939629 25263594 26344197 27173435 28515276 34079125 9774689 unassigned1312 details
U5S1_HUMANWBP4_HUMANBioGRID, MINT16055720 details
U5S1_HUMANCYFP1_HUMANBioGRID, IntAct21988832 28515276 details
U5S1_HUMANGSK3B_HUMANBioGRID, MINT21900206 30711629 details
U5S1_HUMANSF3B4_HUMANBioGRID, MINT22365833 28515276 details
U5S1_HUMANRED_HUMANBioGRID, MINT22365833 details
U5S1_HUMANHSPB1_HUMANBioGRID, MINT22365833 28515276 details
U5S1_HUMANSF3B3_HUMANBioGRID, MINT22365833 22939629 28515276 details
U5S1_HUMANSF01_HUMANBioGRID, MINT22365833 22939629 28515276 details
U5S1_HUMANLSM8_HUMANBioGRID, MINT22365833 28515276 details
U5S1_HUMANDUX4_HUMANBioGRID, IntAct26816005 details
U5S1_HUMANPRP6_HUMANBioGRID, IntAct, UniProt16723661 26344197 27173435 28515276 unassigned1312 details
U5S1_HUMANU520_HUMANBioGRID, IntAct, UniProt16723661 22939629 25263594 25849387 26344197 27173435 28515276 unassigned1312 details
U5S1_HUMANARPC3_HUMANBioGRID, HPRD16169070 28515276 details
U5S1_HUMANSREK1_HUMANBioGRID, HPRD14559993 26344197 details
U5S1_HUMANU5S1_HUMANBioGRID, HPRD16723661 28515276 9774689 details
U5S1_HUMANHINFP_HUMANBioGRID17577209 details
U5S1_HUMANPIN1_HUMANBioGRID16055720 details
U5S1_HUMANZMY11_HUMANBioGRID25263594 details
U5S1_HUMANZNHI2_HUMANBioGRID28515276 28561026 details
U5S1_HUMANSUMO2_HUMANBioGRID32786267 details
U5S1_HUMANGOLM1_HUMANHPRD16169070 details
U5S1_HUMANNFKB2_HUMANIntAct14743216 details
U5S1_HUMANTF65_HUMANIntAct14743216 details
U5S1_HUMANTP4A3_HUMANIntAct17353931 details
U5S1_HUMANDFFA_HUMANIntAct17353931 details
U5S1_HUMAN1433G_HUMANBioGRID, IntAct17353931 28515276 details
U5S1_HUMANAAKB1_HUMANIntAct17353931 details
U5S1_HUMAN1433B_HUMANBioGRID, IntAct17353931 28515276 details
U5S1_HUMANSF3A2_HUMANBioGRID, MINT17332742 details
U5S1_HUMANFKBPL_HUMANIntAct25036637 details
U5S1_HUMANHSF1_HUMANBioGRID, IntAct27173435 unassigned1312 details
U5S1_HUMANRIOK1_HUMANBioGRID, IntAct21081503 27173435 28515276 unassigned1312 details
U5S1_HUMANSMU1_HUMANBioGRID, IntAct27173435 28515276 unassigned1312 details
U5S1_HUMANAIRE_HUMANBioGRID20085707 details
U5S1_HUMANSRRM1_HUMANBioGRID16159877 28515276 details
U5S1_HUMANSRRM2_HUMANBioGRID16159877 28515276 details
U5S1_HUMANHDAC5_HUMANBioGRID21081666 details
U5S1_HUMANTHOC4_HUMANBioGRID15998806 28515276 details
U5S1_HUMANITA4_HUMANBioGRID22623428 details
U5S1_HUMANSIR6_HUMANBioGRID24169447 details
U5S1_HUMANU2AF2_HUMANBioGRID26641092 28515276 details
U5S1_HUMANTTC27_HUMANBioGRID26472760 28515276 details
U5S1_HUMANTLS1_HUMANBioGRID26472760 details
U5S1_HUMANSMC1A_HUMANBioGRID28515276 31010829 details
U5S1_HUMANSMC3_HUMANBioGRID28515276 31010829 details
U5S1_HUMANSTAG2_HUMANBioGRID28515276 31010829 details
U5S1_HUMANPDS5A_HUMANBioGRID28515276 31010829 details
U5S1_HUMANLSM4_HUMANBioGRID28515276 29395067 details
U5S1_HUMANAKTIP_HUMANBioGRID27512140 details
U5S1_HUMANWAPL_HUMANBioGRID31010829 details
U5S1_HUMANISG15_HUMANBioGRID33024031 details