Entity Details

Primary name IRF4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15306
EntryNameIRF4_HUMAN
FullNameInterferon regulatory factor 4
TaxID9606
Evidenceevidence at protein level
Length451
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesIRF4

GO terms

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GOName
GO:0000785 chromatin
GO:0000786 nucleosome
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002376 immune system process
GO:0003700 DNA-binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0008134 transcription factor binding
GO:0016020 membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0032733 positive regulation of interleukin-10 production
GO:0032736 positive regulation of interleukin-13 production
GO:0032743 positive regulation of interleukin-2 production
GO:0032753 positive regulation of interleukin-4 production
GO:0034122 negative regulation of toll-like receptor signaling pathway
GO:0042110 T cell activation
GO:0042832 defense response to protozoan
GO:0043011 myeloid dendritic cell differentiation
GO:0043388 positive regulation of DNA binding
GO:0043565 sequence-specific DNA binding
GO:0043966 histone H3 acetylation
GO:0043967 histone H4 acetylation
GO:0045622 regulation of T-helper cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0072540 T-helper 17 cell lineage commitment
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001346 Interferon regulatory factor DNA-binding domainDomainDomain
IPR008984 SMAD/FHA domain superfamilyFamilyHomologous superfamily
IPR017855 SMAD-like domain superfamilyFamilyHomologous superfamily
IPR019471 Interferon regulatory factor-3DomainDomain
IPR019817 Interferon regulatory factor, conserved siteSiteConserved site
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
254500 OMIMMultiple myeloma (MM)A malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving IRF4 has been found in multiple myeloma. Translocation t(6;14)(p25;q32) with the IgH locus.