Entity Details

Primary name MICB
Entity type gene
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Details

PrimaryID4277
RefseqGeneNG_021405
SymbolMICB
NameMHC class I polypeptide-related sequence B
Chromosome6
Location6p21.33
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1994-11-08
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsMICB_HUMAN

GO terms

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GOName
GO:0002250 adaptive immune response
GO:0002429 immune response-activating cell surface receptor signaling pathway
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0006979 response to oxidative stress
GO:0009408 response to heat
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0016032 viral process
GO:0019835 cytolysis
GO:0032526 response to retinoic acid
GO:0046629 gamma-delta T cell activation
GO:0046703 natural killer cell lectin-like receptor binding
GO:0050689 negative regulation of defense response to virus by host
GO:0050776 regulation of immune response

Diseases

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Disease IDSourceNameDescription
180300 OMIMRheumatoid arthritis (RA)An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Disease susceptibility is associated with variants affecting the gene represented in this entry. The MICB*004 allele is associated with rheumatoid arthritis.