Entity Details

Primary name DUS6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16828
EntryNameDUS6_HUMAN
FullNameDual specificity protein phosphatase 6
TaxID9606
Evidenceevidence at protein level
Length381
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesDUSP6

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000187 obsolete activation of MAPK activity
GO:0000188 obsolete inactivation of MAPK activity
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006470 protein dephosphorylation
GO:0008330 protein tyrosine/threonine phosphatase activity
GO:0014070 response to organic cyclic compound
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity
GO:0030154 cell differentiation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0035970 peptidyl-threonine dephosphorylation
GO:0042493 response to drug
GO:0043065 positive regulation of apoptotic process
GO:0051019 mitogen-activated protein kinase binding
GO:0051409 response to nitrosative stress
GO:0060420 regulation of heart growth
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070848 response to growth factor
GO:0106306 protein serine phosphatase activity
GO:0106307 protein threonine phosphatase activity

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000387 Tyrosine specific protein phosphatases domainDomainDomain
IPR001763 Rhodanese-like domainDomainDomain
IPR008343 Mitogen-activated protein (MAP) kinase phosphataseFamilyFamily
IPR020422 Dual specificity protein phosphatase domainDomainDomain
IPR029021 Protein-tyrosine phosphatase-likeFamilyHomologous superfamily
IPR036873 Rhodanese-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
615269 OMIMHypogonadotropic hypogonadism 19 with or without anosmia (HH19)A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). The disease is caused by variants affecting distinct genetic loci, including the gene represented in this entry. Some patients carrying mutations in DUSP6 also have a heterozygous mutation in another HH-associated gene including FGFR1 and SPRY4 (PubMed:23643382).