Entity Details

Primary name ATS13_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ76LX8
EntryNameATS13_HUMAN
FullNameA disintegrin and metalloproteinase with thrombospondin motifs 13
TaxID9606
Evidenceevidence at protein level
Length1427
SequenceStatuscomplete
DateCreated2006-07-25
DateModified2021-06-02

Ontological Relatives

GenesADAMTS13

GO terms

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GOName
GO:0004222 metalloendopeptidase activity
GO:0005178 integrin binding
GO:0005509 calcium ion binding
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0006508 proteolysis
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0009100 glycoprotein metabolic process
GO:0009636 response to toxic substance
GO:0009986 cell surface
GO:0014075 response to amine
GO:0016485 protein processing
GO:0030168 platelet activation
GO:0030198 extracellular matrix organization
GO:0031012 extracellular matrix
GO:0035864 response to potassium ion
GO:0043171 peptide catabolic process
GO:0071222 cellular response to lipopolysaccharide
GO:0071346 cellular response to interferon-gamma
GO:0071353 cellular response to interleukin-4
GO:0071356 cellular response to tumor necrosis factor

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000884 Thrombospondin type-1 (TSP1) repeatRepeatRepeat
IPR001590 Peptidase M12B, ADAM/reprolysinDomainDomain
IPR006586 ADAM, cysteine-rich domainDomainDomain
IPR013273 ADAMTS/ADAMTS-likeFamilyFamily
IPR024079 Metallopeptidase, catalytic domain superfamilyFamilyHomologous superfamily
IPR035914 Spermadhesin, CUB domain superfamilyFamilyHomologous superfamily
IPR036383 Thrombospondin type-1 (TSP1) repeat superfamilyFamilyHomologous superfamily
IPR041645 ADAM cysteine-rich domain 2DomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB12872 Vonicog AlfaDrugbankbiotech
DB13133 Von Willebrand Factor HumanDrugbankbiotech

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
ATS13_HUMANVWF_HUMANDIP, HPRD, IntAct12775718 15824096 16221672 18492805 25512528 details
ATS13_HUMANFA8_HUMANDIP18492805 details