Entity Details

Primary name MTA70_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ86U44
EntryNameMTA70_HUMAN
FullNameN6-adenosine-methyltransferase catalytic subunit
TaxID9606
Evidenceevidence at protein level
Length580
SequenceStatuscomplete
DateCreated2003-07-25
DateModified2021-06-02

Ontological Relatives

GenesMETTL3

GO terms

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GOName
GO:0000398 mRNA splicing, via spliceosome
GO:0001510 RNA methylation
GO:0001734 mRNA (N6-adenosine)-methyltransferase activity
GO:0003729 mRNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006382 adenosine to inosine editing
GO:0006397 mRNA processing
GO:0006402 mRNA catabolic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007283 spermatogenesis
GO:0007623 circadian rhythm
GO:0008168 methyltransferase activity
GO:0008173 RNA methyltransferase activity
GO:0009048 dosage compensation by inactivation of X chromosome
GO:0016070 RNA metabolic process
GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
GO:0016607 nuclear speck
GO:0019827 stem cell population maintenance
GO:0021861 forebrain radial glial cell differentiation
GO:0031053 primary miRNA processing
GO:0034644 cellular response to UV
GO:0036396 RNA N6-methyladenosine methyltransferase complex
GO:0042063 gliogenesis
GO:0045087 innate immune response
GO:0045580 regulation of T cell differentiation
GO:0045727 positive regulation of translation
GO:0045746 negative regulation of Notch signaling pathway
GO:0046982 protein heterodimerization activity
GO:0048477 oogenesis
GO:0051445 regulation of meiotic cell cycle
GO:0060339 negative regulation of type I interferon-mediated signaling pathway
GO:0061157 mRNA destabilization
GO:0080009 mRNA methylation
GO:0098508 endothelial to hematopoietic transition
GO:1902036 regulation of hematopoietic stem cell differentiation
GO:1903679 positive regulation of cap-independent translational initiation
GO:1904047 S-adenosyl-L-methionine binding
GO:1990744 primary miRNA methylation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus
Nucleus speckle

Domains

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DomainNameCategoryType
IPR007757 MT-A70-likeFamilyFamily
IPR025848 N6-adenosine-methyltransferase MT-A70-likeFamilyFamily
IPR029063 S-adenosyl-L-methionine-dependent methyltransferaseFamilyHomologous superfamily

Diseases

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