Entity Details

Primary name STING_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ86WV6
EntryNameSTING_HUMAN
FullNameStimulator of interferon genes protein
TaxID9606
Evidenceevidence at protein level
Length379
SequenceStatuscomplete
DateCreated2007-01-09
DateModified2021-06-02

Ontological Relatives

GenesSTING1

GO terms

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GOName
GO:0000045 autophagosome assembly
GO:0000421 autophagosome membrane
GO:0002218 activation of innate immune response
GO:0002230 positive regulation of defense response to virus by host
GO:0005654 nucleoplasm
GO:0005741 mitochondrial outer membrane
GO:0005768 endosome
GO:0005776 autophagosome
GO:0005777 peroxisome
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0008134 transcription factor binding
GO:0016032 viral process
GO:0016239 positive regulation of macroautophagy
GO:0019901 protein kinase binding
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0030667 secretory granule membrane
GO:0031625 ubiquitin protein ligase binding
GO:0032092 positive regulation of protein binding
GO:0032479 regulation of type I interferon production
GO:0032481 positive regulation of type I interferon production
GO:0032728 positive regulation of interferon-beta production
GO:0035438 cyclic-di-GMP binding
GO:0035458 cellular response to interferon-beta
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043312 neutrophil degranulation
GO:0045087 innate immune response
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048471 perinuclear region of cytoplasm
GO:0050727 regulation of inflammatory response
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051259 protein complex oligomerization
GO:0051607 defense response to virus
GO:0061507 cyclic-GMP-AMP binding
GO:0061709 reticulophagy
GO:0071360 cellular response to exogenous dsRNA
GO:0071407 cellular response to organic cyclic compound
GO:1990701 integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Cytoplasmic vesicle
Endoplasmic reticulum membrane
Endoplasmic reticulum-Golgi intermediate compartment membrane
Mitochondrion outer membrane

Domains

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DomainNameCategoryType
IPR029158 Stimulator of interferon genes proteinFamilyFamily
IPR033952 Stimulator of interferon genes protein, C-terminalDomainDomain
IPR038623 Stimulator of interferon genes protein, C-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
615934 OMIMSTING-associated vasculopathy, infantile-onset (SAVI)An autoinflammatory disease characterized by early-onset systemic inflammation and cutaneous vasculopathy, resulting in severe skin lesions. Violaceous, scaling lesions of fingers, toes, nose, cheeks and ears progress to acral necrosis in most of the patients. Some patients have severe interstitial lung disease. The disease is caused by variants affecting the gene represented in this entry.

Interactions

61 interactions

InteractorPartnerSourcesPublicationsLink
STING_HUMANIF16_HUMANBioGRID, InnateDB20890285 26121674 27764250 30193098 31665637 details
STING_HUMANSTAT6_HUMANIntAct22000020 details
STING_HUMANIRAK1_HUMANBioGRID, IntAct21903422 details
STING_HUMANSTT3A_HUMANBioGRID, IntAct21903422 details
STING_HUMANOST48_HUMANBioGRID, IntAct21903422 details
STING_HUMANSURF4_HUMANBioGRID, IntAct21903422 29251827 details
STING_HUMANSGPL1_HUMANBioGRID, IntAct21903422 details
STING_HUMANCCD47_HUMANBioGRID, IntAct21903422 details
STING_HUMANLTN1_HUMANBioGRID, IntAct21903422 details
STING_HUMANMBOA7_HUMANBioGRID, IntAct21903422 details
STING_HUMANZNF16_HUMANUniProt21874239 details
STING_HUMANSTING_HUMANBioGRID, DIP, HPIDb, IntAct19433799 21074459 22312431 22728658 22728659 22728660 23542348 30018345 30405246 30842659 33086059 details
STING_HUMANCKLF5_HUMANBioGRID, IntAct32296183 details
STING_HUMANPLLP_HUMANBioGRID, IntAct32296183 details
STING_HUMANTECR_HUMANBioGRID, IntAct32296183 details
STING_HUMANREEP6_HUMANBioGRID, IntAct32296183 details
STING_HUMANTM100_HUMANBioGRID, IntAct32296183 details
STING_HUMANYIPF2_HUMANBioGRID, IntAct32296183 details
STING_HUMANSMIM1_HUMANBioGRID, IntAct32296183 details
STING_HUMANSTX5_HUMANBioGRID, IntAct32296183 details
STING_HUMANLERL1_HUMANBioGRID, IntAct32296183 details
STING_HUMANSSRB_HUMANDIP18724357 details
STING_HUMANTRI32_HUMANBioGRID22745133 details
STING_HUMANRNF26_HUMANBioGRID25254379 details
STING_HUMANUBP20_HUMANBioGRID27801882 30814308 details
STING_HUMANUBP49_HUMANBioGRID27801882 30943264 details
STING_HUMANMUL1_HUMANBioGRID28763789 details
STING_HUMANMYSM1_HUMANBioGRID33086059 details
STING_HUMANRN115_HUMANBioGRID33139700 details
STING_HUMANMAVS_HUMANBioGRID, DIP, HPIDb, IntAct18724357 19416887 20080758 22000020 22312431 22908223 22911572 23542348 24622840 details
STING_HUMANTBK1_HUMANBioGRID, DIP, HPIDb, IntAct18724357 19416887 19433799 21074459 21903422 22745133 23542348 24622840 28346439 28763789 29899553 30943264 31534043 32383759 33086059 33139700 details
STING_HUMANDDX58_HUMANBioGRID, DIP, IntAct18724357 22312431 details
STING_HUMANIFIT2_HUMANDIP19416887 details
STING_HUMANIFIT1_HUMANDIP19416887 details
STING_HUMANIKKE_HUMANBioGRID, DIP19433799 22312431 28346439 details
STING_HUMANIRF3_HUMANBioGRID, IntAct24622840 25636800 30018345 33086059 details
STING_HUMANUBB_HUMANIntAct24622840 details
STING_HUMANTRI56_HUMANBioGRID21074459 details
STING_HUMANRNF5_HUMANBioGRID19285439 details
STING_HUMANTSN6_HUMANBioGRID22908223 details
STING_HUMANTOM70_HUMANBioGRID20628368 details
STING_HUMANTRAF3_HUMANBioGRID24622840 27716849 details
STING_HUMANUBP18_HUMANBioGRID27801882 details
STING_HUMANUBP2_HUMANBioGRID27801882 details
STING_HUMANUBP3_HUMANBioGRID27801882 details
STING_HUMANUBP13_HUMANBioGRID27801882 details
STING_HUMANUBP22_HUMANBioGRID27801882 details
STING_HUMANUBP35_HUMANBioGRID27801882 details
STING_HUMANUBP50_HUMANBioGRID27801882 details
STING_HUMANPAN2_HUMANBioGRID27801882 details
STING_HUMANTNR5_HUMANBioGRID27716849 details
STING_HUMANTRAF2_HUMANBioGRID27716849 details
STING_HUMANFAF2_HUMANBioGRID29899553 details
STING_HUMANP53_HUMANBioGRID30193098 details
STING_HUMANTRAF6_HUMANBioGRID30193098 details
STING_HUMANM3K14_HUMANBioGRID30018345 details
STING_HUMANCYLD_HUMANBioGRID30388174 details
STING_HUMANH2B2E_HUMANBioGRID27764250 details
STING_HUMANCGAS_HUMANBioGRID27764250 details
STING_HUMANMARH1_HUMANBioGRID32606244 details
STING_HUMANOTUD5_HUMANBioGRID32879469 details