Entity Details

Primary name ABCA7_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8IZY2
EntryNameABCA7_HUMAN
FullNamePhospholipid-transporting ATPase ABCA7
TaxID9606
Evidenceevidence at protein level
Length2146
SequenceStatuscomplete
DateCreated2006-10-03
DateModified2021-06-02

Ontological Relatives

GenesABCA7

GO terms

Show/Hide Table
GOName
GO:0000139 Golgi membrane
GO:0001891 phagocytic cup
GO:0005319 lipid transporter activity
GO:0005524 ATP binding
GO:0005548 phospholipid transporter activity
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0006869 lipid transport
GO:0006909 phagocytosis
GO:0007613 memory
GO:0008542 visual learning
GO:0009986 cell surface
GO:0010875 positive regulation of cholesterol efflux
GO:0016021 integral component of membrane
GO:0018149 peptide cross-linking
GO:0019216 regulation of lipid metabolic process
GO:0030054 cell junction
GO:0031901 early endosome membrane
GO:0032587 ruffle membrane
GO:0033344 cholesterol efflux
GO:0033700 phospholipid efflux
GO:0034188 apolipoprotein A-I receptor activity
GO:0034205 amyloid-beta formation
GO:0034380 high-density lipoprotein particle assembly
GO:0034504 protein localization to nucleus
GO:0038027 apolipoprotein A-I-mediated signaling pathway
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0042985 negative regulation of amyloid precursor protein biosynthetic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043409 negative regulation of MAPK cascade
GO:0044857 plasma membrane raft organization
GO:0045332 phospholipid translocation
GO:0045806 negative regulation of endocytosis
GO:0050766 positive regulation of phagocytosis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090554 phosphatidylcholine floppase activity
GO:0090556 phosphatidylserine floppase activity
GO:0097386 glial cell projection
GO:0140328 floppase activity
GO:0150094 amyloid-beta clearance by cellular catabolic process
GO:1900223 positive regulation of amyloid-beta clearance
GO:1901076 positive regulation of engulfment of apoptotic cell
GO:1902430 negative regulation of amyloid-beta formation
GO:1902991 regulation of amyloid precursor protein catabolic process
GO:1902995 positive regulation of phospholipid efflux
GO:1903898 negative regulation of PERK-mediated unfolded protein response
GO:2000010 positive regulation of protein localization to cell surface

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Cell projection
Cytoplasm
Early endosome membrane
Endoplasmic reticulum
Golgi apparatus membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR003439 ABC transporter-like, ATP-binding domainDomainDomain
IPR003593 AAA+ ATPase domainDomainDomain
IPR017871 ABC transporter-like, conserved siteSiteConserved site
IPR026082 ABC transporter AFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR030369 ATP-binding cassette subfamily A member 7FamilyFamily

Diseases

Show/Hide Table

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
ABCA7_HUMANADRB2_HUMANBioGRID, MINT28298427 details
ABCA7_HUMANC5AR2_HUMANBioGRID, MINT28298427 details