Entity Details

Primary name FLCN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8NFG4
EntryNameFLCN_HUMAN
FullNameFolliculin
TaxID9606
Evidenceevidence at protein level
Length579
SequenceStatuscomplete
DateCreated2006-02-21
DateModified2021-06-02

Ontological Relatives

GenesFLCN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001701 in utero embryonic development
GO:0001932 regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005929 cilium
GO:0007043 cell-cell junction assembly
GO:0009267 cellular response to starvation
GO:0010508 positive regulation of autophagy
GO:0010629 negative regulation of gene expression
GO:0010823 negative regulation of mitochondrion organization
GO:0030097 hemopoiesis
GO:0030308 negative regulation of cell growth
GO:0030336 negative regulation of cell migration
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0031929 TOR signaling
GO:0032006 regulation of TOR signaling
GO:0032007 negative regulation of TOR signaling
GO:0032008 positive regulation of TOR signaling
GO:0032418 lysosome localization
GO:0032465 regulation of cytokinesis
GO:0034198 cellular response to amino acid starvation
GO:0035024 negative regulation of Rho protein signal transduction
GO:0035065 regulation of histone acetylation
GO:0043065 positive regulation of apoptotic process
GO:0043547 positive regulation of GTPase activity
GO:0044877 protein-containing complex binding
GO:0045785 positive regulation of cell adhesion
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046578 regulation of Ras protein signal transduction
GO:0051898 negative regulation of protein kinase B signaling
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0072686 mitotic spindle
GO:0097009 energy homeostasis
GO:0120163 negative regulation of cold-induced thermogenesis
GO:1900181 negative regulation of protein localization to nucleus
GO:1901723 negative regulation of cell proliferation involved in kidney development
GO:1903444 negative regulation of brown fat cell differentiation
GO:1904263 positive regulation of TORC1 signaling
GO:2000973 regulation of pro-B cell differentiation
GO:2001170 negative regulation of ATP biosynthetic process

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm
Lysosome membrane
Nucleus

Domains

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DomainNameCategoryType
IPR021713 FolliculinFamilyFamily
IPR032035 Folliculin, DENN domainDomainDomain
IPR037520 Folliculin/SMCR8, longin domainDomainDomain
IPR037521 Folliculin/SMCR8, tripartite DENN domainDomainDomain

Diseases

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Interactions

59 interactions

InteractorPartnerSourcesPublicationsLink
FLCN_HUMANGBRAP_HUMANBioGRID, IntAct20562859 25126726 details
FLCN_HUMANALDOB_HUMANBioGRID, MINT24412244 details
FLCN_HUMANTSTD2_HUMANBioGRID, MINT24412244 details
FLCN_HUMANF16P1_HUMANBioGRID, MINT24412244 details
FLCN_HUMANHEMGN_HUMANBioGRID, MINT24412244 details
FLCN_HUMANCC180_HUMANBioGRID, MINT24412244 details
FLCN_HUMANSIAS_HUMANBioGRID, MINT24412244 details
FLCN_HUMANTEFF1_HUMANBioGRID, MINT24412244 details
FLCN_HUMANFNIP1_HUMANBioGRID, DIP, UniProt17028174 18403135 27353360 28656962 33137092 details
FLCN_HUMANA4_HUMANBioGRID21832049 details
FLCN_HUMANULK1_HUMANBioGRID25126726 details
FLCN_HUMANMLP3B_HUMANBioGRID25126726 details
FLCN_HUMANHS90A_HUMANBioGRID27353360 details
FLCN_HUMANFNIP2_HUMANBioGRID, UniProt18403135 25126726 27353360 28656962 33137092 details
FLCN_HUMANSF3B1_HUMANBioGRID27353360 details
FLCN_HUMANSF3B3_HUMANBioGRID27353360 details
FLCN_HUMANHS71A_HUMANBioGRID27353360 details
FLCN_HUMANHS71B_HUMANBioGRID27353360 details
FLCN_HUMANTCPQ_HUMANBioGRID27353360 details
FLCN_HUMANTCPB_HUMANBioGRID27353360 details
FLCN_HUMANTCPH_HUMANBioGRID27353360 details
FLCN_HUMANTCPD_HUMANBioGRID27353360 details
FLCN_HUMANAHSA1_HUMANBioGRID27353360 details
FLCN_HUMANCHIP_HUMANBioGRID27353360 details
FLCN_HUMANRL10_HUMANBioGRID27353360 details
FLCN_HUMANPPP5_HUMANBioGRID27353360 details
FLCN_HUMANSTIP1_HUMANBioGRID27353360 details
FLCN_HUMANCDC37_HUMANBioGRID27353360 details
FLCN_HUMANTEBP_HUMANBioGRID27353360 details
FLCN_HUMANRAB7A_HUMANBioGRID28656962 details
FLCN_HUMANRAB7B_HUMANBioGRID28656962 details
FLCN_HUMANRAB35_HUMANBioGRID28656962 details
FLCN_HUMANRAB9A_HUMANBioGRID28656962 details
FLCN_HUMANPI42C_HUMANBioGRID28656962 details
FLCN_HUMANRAB13_HUMANBioGRID28656962 details
FLCN_HUMANRIN1_HUMANBioGRID28656962 details
FLCN_HUMANRAB12_HUMANBioGRID28656962 details
FLCN_HUMANNARR_HUMANBioGRID28656962 details
FLCN_HUMANRAB34_HUMANBioGRID28656962 details
FLCN_HUMANRAB1A_HUMANBioGRID28656962 details
FLCN_HUMANRFIP1_HUMANBioGRID28656962 details
FLCN_HUMANRAB3B_HUMANBioGRID28656962 details
FLCN_HUMANRAB5C_HUMANBioGRID28656962 details
FLCN_HUMANRAB2A_HUMANBioGRID28656962 details
FLCN_HUMANRB33B_HUMANBioGRID28656962 details
FLCN_HUMANRABL3_HUMANBioGRID28656962 details
FLCN_HUMANRAB18_HUMANBioGRID28656962 details
FLCN_HUMANRAB7L_HUMANBioGRID28656962 details
FLCN_HUMANRB3GP_HUMANBioGRID28656962 details
FLCN_HUMANRB6I2_HUMANBioGRID28656962 details
FLCN_HUMANRAB10_HUMANBioGRID28656962 details
FLCN_HUMANRAB14_HUMANBioGRID28656962 details
FLCN_HUMANRAB8A_HUMANBioGRID28656962 details
FLCN_HUMANRAB32_HUMANBioGRID28656962 details
FLCN_HUMANTBA1B_HUMANBioGRID28656962 details
FLCN_HUMANALDOA_HUMANBioGRID28656962 details
FLCN_HUMANAHNK_HUMANBioGRID28656962 details
FLCN_HUMANMEP50_HUMANBioGRID28656962 details
FLCN_HUMANUBP7_HUMANBioGRID33137092 details