Entity Details

Primary name SPP2A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8TCT8
EntryNameSPP2A_HUMAN
FullNameSignal peptide peptidase-like 2A
TaxID9606
Evidenceevidence at protein level
Length520
SequenceStatuscomplete
DateCreated2002-11-08
DateModified2021-06-02

Ontological Relatives

GenesSPPL2A

GO terms

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GOName
GO:0005765 lysosomal membrane
GO:0005770 late endosome
GO:0005886 plasma membrane
GO:0006509 membrane protein ectodomain proteolysis
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0016020 membrane
GO:0030660 Golgi-associated vesicle membrane
GO:0031293 membrane protein intracellular domain proteolysis
GO:0031902 late endosome membrane
GO:0033619 membrane protein proteolysis
GO:0042500 aspartic endopeptidase activity, intramembrane cleaving
GO:0042803 protein homodimerization activity
GO:0043231 intracellular membrane-bounded organelle
GO:0050776 regulation of immune response
GO:0070062 extracellular exosome
GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane

Subcellular Location

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Subcellular Location
Late endosome membrane
Lysosome membrane
Membrane

Domains

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DomainNameCategoryType
IPR003137 PA domainDomainDomain
IPR006639 Presenilin/signal peptide peptidaseFamilyFamily
IPR007369 Peptidase A22B, signal peptide peptidaseFamilyFamily

Diseases

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Interactions

4 interactions