Entity Details

Primary name NRG2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14511
EntryNameNRG2_HUMAN
FullNamePro-neuregulin-2, membrane-bound isoform
TaxID9606
Evidenceevidence at protein level
Length850
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesNRG2

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0005102 signaling receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0007165 signal transduction
GO:0007399 nervous system development
GO:0008083 growth factor activity
GO:0016021 integral component of membrane
GO:0035556 intracellular signal transduction
GO:0038128 ERBB2 signaling pathway
GO:0048513 animal organ development
GO:0051897 positive regulation of protein kinase B signaling
GO:2000145 regulation of cell motility

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR000742 EGF-like domainDomainDomain
IPR002154 Neuregulin, C-terminalDomainDomain
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013098 Immunoglobulin I-setDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR040180 NeuregulinFamilyFamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
NRG2_HUMANERBB4_HUMANBioGRID, HPRD15358134 9168114 9168115 details
NRG2_HUMANERBB3_HUMANBioGRID, HPRD15358134 9168114 9168115 details