Entity Details

Primary name TAF4B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92750
EntryNameTAF4B_HUMAN
FullNameTranscription initiation factor TFIID subunit 4B
TaxID9606
Evidenceevidence at protein level
Length862
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesTAF4B

GO terms

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GOName
GO:0001650 fibrillar center
GO:0003677 DNA binding
GO:0005654 nucleoplasm
GO:0005669 transcription factor TFIID complex
GO:0005737 cytoplasm
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007283 spermatogenesis
GO:0016251 RNA polymerase II general transcription initiation factor activity
GO:0046982 protein heterodimerization activity
GO:0048477 oogenesis
GO:0051059 NF-kappaB binding
GO:1901796 regulation of signal transduction by p53 class mediator

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR003894 TAFH/NHR1DomainDomain
IPR007900 Transcription initiation factor TFIID component TAF4, C-terminalDomainDomain
IPR009072 Histone-foldFamilyHomologous superfamily
IPR037249 TAFH/NHR1 domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
615841 OMIMSpermatogenic failure 13 (SPGF13)A disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. The disease is caused by variants affecting the gene represented in this entry.