Entity Details

Primary name FOXJ1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92949
EntryNameFOXJ1_HUMAN
FullNameForkhead box protein J1
TaxID9606
Evidenceevidence at protein level
Length421
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesFOXJ1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002508 central tolerance induction
GO:0002635 negative regulation of germinal center formation
GO:0002897 positive regulation of central B cell tolerance induction
GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006959 humoral immune response
GO:0007283 spermatogenesis
GO:0007368 determination of left/right symmetry
GO:0007389 pattern specification process
GO:0007420 brain development
GO:0007507 heart development
GO:0030036 actin cytoskeleton organization
GO:0032053 ciliary basal body organization
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032715 negative regulation of interleukin-6 production
GO:0033085 negative regulation of T cell differentiation in thymus
GO:0034613 cellular protein localization
GO:0035082 axoneme assembly
GO:0035089 establishment of apical/basal cell polarity
GO:0035502 metanephric part of ureteric bud development
GO:0042130 negative regulation of T cell proliferation
GO:0044458 motile cilium assembly
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050869 negative regulation of B cell activation
GO:0050900 leukocyte migration
GO:0060271 cilium assembly
GO:0060428 lung epithelium development
GO:0060429 epithelium development
GO:0060972 left/right pattern formation
GO:0072016 glomerular parietal epithelial cell development
GO:0090630 activation of GTPase activity
GO:1901248 positive regulation of lung ciliated cell differentiation

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001766 Fork head domainDomainDomain
IPR018122 Fork head domain conserved site1SiteConserved site
IPR030456 Fork head domain conserved site 2SiteConserved site
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
618699 OMIMCiliary dyskinesia, primary, 43 (CILD43)A form of primary ciliary dyskinesia, a disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. Patients with this disorder also develop significant obstructive hydrocephalus. Other more variable features include infertility and about a 50% chance of situs inversus or other left-right asymmetry defects. CILD43 inheritance is autosomal dominant. The disease is caused by variants affecting the gene represented in this entry.
607154 OMIMAllergic rhinitis (ALRH)A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure. Disease susceptibility may be associated with variants affecting the gene represented in this entry.