Entity Details

Primary name NSD1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96L73
EntryNameNSD1_HUMAN
FullNameHistone-lysine N-methyltransferase, H3 lysine-36 specific
TaxID9606
Evidenceevidence at protein level
Length2696
SequenceStatuscomplete
DateCreated2003-07-03
DateModified2021-06-02

Ontological Relatives

GenesNSD1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000414 regulation of histone H3-K36 methylation
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003682 chromatin binding
GO:0003712 transcription coregulator activity
GO:0003714 transcription corepressor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006355 regulation of transcription, DNA-templated
GO:0008270 zinc ion binding
GO:0016571 histone methylation
GO:0030331 estrogen receptor binding
GO:0033135 regulation of peptidyl-serine phosphorylation
GO:0042799 histone methyltransferase activity (H4-K20 specific)
GO:0042974 retinoic acid receptor binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046965 retinoid X receptor binding
GO:0046966 thyroid hormone receptor binding
GO:0046975 histone methyltransferase activity (H3-K36 specific)
GO:0050681 androgen receptor binding
GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR000313 PWWP domainDomainDomain
IPR001214 SET domainDomainDomain
IPR001965 Zinc finger, PHD-typeDomainDomain
IPR003616 Post-SET domainDomainDomain
IPR006560 AWS domainDomainDomain
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR019786 Zinc finger, PHD-type, conserved siteSiteConserved site
IPR019787 Zinc finger, PHD-fingerDomainDomain
IPR041306 NSD, Cys-His rich domainDomainDomain

Diseases

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Interactions

36 interactions

InteractorPartnerSourcesPublicationsLink
NSD1_HUMANMDFI_HUMANBioGRID, IntAct32296183 details
NSD1_HUMANCC125_HUMANBioGRID, IntAct32296183 details
NSD1_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
NSD1_HUMANAGR2_HUMANBioGRID, IntAct32296183 details
NSD1_HUMANKRA62_HUMANBioGRID, IntAct32296183 details
NSD1_HUMANH12_HUMANBioGRID, IntAct24412544 30021884 details
NSD1_HUMANESR1_HUMANBioGRID, HPRD, IntAct23975195 31527615 9628876 details
NSD1_HUMANZN496_HUMANBioGRID, HPRD15169884 details
NSD1_HUMANANDR_HUMANBioGRID, HPRD11266437 11509567 23975195 details
NSD1_HUMANH4_HUMANBioGRID21806967 24412544 25494638 30804502 details
NSD1_HUMANTNR21_HUMANBioGRID15623156 details
NSD1_HUMANRARA_HUMANBioGRID, HPRD23975195 9628876 details
NSD1_HUMANRXRA_HUMANBioGRID, HPRD23975195 9628876 details
NSD1_HUMANPPARG_HUMANBioGRID23975195 details
NSD1_HUMANVDR_HUMANBioGRID23975195 details
NSD1_HUMANTHB_HUMANBioGRID23975195 details
NSD1_HUMANRORA_HUMANBioGRID23975195 details
NSD1_HUMANHNF4G_HUMANBioGRID23975195 details
NSD1_HUMANNR2F6_HUMANBioGRID23975195 details
NSD1_HUMANERR1_HUMANBioGRID23975195 details
NSD1_HUMANNR5A2_HUMANBioGRID23975195 details
NSD1_HUMANNR6A1_HUMANBioGRID23975195 details
NSD1_HUMANCOT1_HUMANBioGRID23975195 details
NSD1_HUMANCOT2_HUMANBioGRID23975195 details
NSD1_HUMANNR2E1_HUMANBioGRID23975195 details
NSD1_HUMANH31T_HUMANBioGRID24412544 details
NSD1_HUMANH15_HUMANBioGRID24412544 details
NSD1_HUMANATRX_HUMANBioGRID24412544 details
NSD1_HUMANH13_HUMANBioGRID24412544 details
NSD1_HUMANH31_HUMANBioGRID25494638 26912663 34079125 details
NSD1_HUMANRPB1_HUMANBioGRID25193115 details
NSD1_HUMANNTRK3_HUMANBioGRID24034695 details
NSD1_HUMANTF65_HUMANBioGRID, DIP20080798 details
NSD1_HUMANAFF1_HUMANBioGRID21030982 details
NSD1_HUMANCUL4B_HUMANBioGRID24292684 details
NSD1_HUMANTHA_HUMANHPRD9628876 details