Entity Details

Primary name MESP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9BRJ9
EntryNameMESP1_HUMAN
FullNameMesoderm posterior protein 1
TaxID9606
Evidenceevidence at protein level
Length268
SequenceStatuscomplete
DateCreated2007-09-11
DateModified2021-06-02

Ontological Relatives

GenesMESP1

GO terms

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GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001707 mesoderm formation
GO:0001947 heart looping
GO:0003007 heart morphogenesis
GO:0003139 secondary heart field specification
GO:0003143 embryonic heart tube morphogenesis
GO:0003210 cardiac atrium formation
GO:0003211 cardiac ventricle formation
GO:0003236 sinus venosus morphogenesis
GO:0003241 growth involved in heart morphogenesis
GO:0003259 cardioblast anterior-lateral migration
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007219 Notch signaling pathway
GO:0007369 gastrulation
GO:0008078 mesodermal cell migration
GO:0010467 gene expression
GO:0022008 neurogenesis
GO:0023019 signal transduction involved in regulation of gene expression
GO:0032525 somite rostral/caudal axis specification
GO:0035481 positive regulation of Notch signaling pathway involved in heart induction
GO:0042662 negative regulation of mesodermal cell fate specification
GO:0042664 negative regulation of endodermal cell fate specification
GO:0045446 endothelial cell differentiation
GO:0045747 positive regulation of Notch signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046983 protein dimerization activity
GO:0048368 lateral mesoderm development
GO:0051155 positive regulation of striated muscle cell differentiation
GO:0055007 cardiac muscle cell differentiation
GO:0060913 cardiac cell fate determination
GO:0060921 sinoatrial node cell differentiation
GO:0060947 cardiac vascular smooth muscle cell differentiation
GO:0060975 cardioblast migration to the midline involved in heart field formation
GO:0070368 positive regulation of hepatocyte differentiation
GO:0090082 positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily
IPR040259 Mesogenin/MesPFamilyFamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
MESP1_HUMANTFE2_HUMANIntAct26694203 details
MESP1_HUMANSPRE1_HUMANIntAct32814053 details