Entity Details

Primary name SPTC2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15270
EntryNameSPTC2_HUMAN
FullNameSerine palmitoyltransferase 2
TaxID9606
Evidenceevidence at protein level
Length562
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesSPTLC2

GO terms

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GOName
GO:0004758 serine C-palmitoyltransferase activity
GO:0005789 endoplasmic reticulum membrane
GO:0006686 sphingomyelin biosynthetic process
GO:0016021 integral component of membrane
GO:0017059 serine C-palmitoyltransferase complex
GO:0030148 sphingolipid biosynthetic process
GO:0030170 pyridoxal phosphate binding
GO:0046511 sphinganine biosynthetic process
GO:0046512 sphingosine biosynthetic process
GO:0046513 ceramide biosynthetic process
GO:0060612 adipose tissue development
GO:1904504 positive regulation of lipophagy

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR001917 Aminotransferase, class-II, pyridoxal-phosphate binding siteSiteBinding site
IPR004839 Aminotransferase, class I/classIIDomainDomain
IPR015421 Pyridoxal phosphate-dependent transferase, major domainFamilyHomologous superfamily
IPR015422 Pyridoxal phosphate-dependent transferase, small domainFamilyHomologous superfamily
IPR015424 Pyridoxal phosphate-dependent transferaseFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00114 Pyridoxal phosphateDrugbanksmall molecule
DB00133 SerineDrugbanksmall molecule