Entity Details

Primary name DLL4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NR61
EntryNameDLL4_HUMAN
FullNameDelta-like protein 4
TaxID9606
Evidenceevidence at protein level
Length685
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesDLL4

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001525 angiogenesis
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001974 blood vessel remodeling
GO:0003180 aortic valve morphogenesis
GO:0003208 cardiac ventricle morphogenesis
GO:0003209 cardiac atrium morphogenesis
GO:0003222 ventricular trabecula myocardium morphogenesis
GO:0003344 pericardium morphogenesis
GO:0005112 Notch binding
GO:0005509 calcium ion binding
GO:0005886 plasma membrane
GO:0007165 signal transduction
GO:0007219 Notch signaling pathway
GO:0007601 visual perception
GO:0008015 blood circulation
GO:0008285 negative regulation of cell population proliferation
GO:0010596 negative regulation of endothelial cell migration
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0016021 integral component of membrane
GO:0030217 T cell differentiation
GO:0035912 dorsal aorta morphogenesis
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0045746 negative regulation of Notch signaling pathway
GO:0045747 positive regulation of Notch signaling pathway
GO:0050767 regulation of neurogenesis
GO:0060579 ventral spinal cord interneuron fate commitment
GO:0061074 regulation of neural retina development
GO:0061314 Notch signaling involved in heart development
GO:0072554 blood vessel lumenization
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:2000179 positive regulation of neural precursor cell proliferation

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000742 EGF-like domainDomainDomain
IPR001774 Delta/Serrate/lag-2 (DSL) proteinDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011651 Notch ligand, N-terminal domainDomainDomain

Diseases

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Interactions

3 interactions