Entity Details

Primary name I36RA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UBH0
EntryNameI36RA_HUMAN
FullNameInterleukin-36 receptor antagonist protein
TaxID9606
Evidenceevidence at protein level
Length155
SequenceStatuscomplete
DateCreated2002-11-08
DateModified2021-06-02

Ontological Relatives

GenesIL36RN

GO terms

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GOName
GO:0001960 negative regulation of cytokine-mediated signaling pathway
GO:0002437 inflammatory response to antigenic stimulus
GO:0005125 cytokine activity
GO:0005149 interleukin-1 receptor binding
GO:0005152 interleukin-1 receptor antagonist activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0006954 inflammatory response
GO:0019221 cytokine-mediated signaling pathway
GO:0019732 antifungal humoral response
GO:0032689 negative regulation of interferon-gamma production
GO:0032700 negative regulation of interleukin-17 production
GO:0032715 negative regulation of interleukin-6 production
GO:0045087 innate immune response
GO:0071222 cellular response to lipopolysaccharide

Subcellular Location

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Subcellular Location
Cytoplasm
Secreted

Domains

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DomainNameCategoryType
IPR000975 Interleukin-1 familyFamilyFamily
IPR003297 Interleukin-1 receptor antagonist/Interleukin-36FamilyFamily
IPR008996 Cytokine IL1/FGFFamilyHomologous superfamily
IPR020877 Interleukin-1 conserved siteSiteConserved site
IPR027171 Interleukin-36 receptor antagonistFamilyFamily

Diseases

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Disease IDSourceNameDescription
614204 OMIMPsoriasis 14, pustular (PSORS14)A life-threatening disease defined by repeated flares of sudden onset consisting of diffuse erythematous skin eruption characterized by rapid coverage with pustules, high-grade fever, asthenia, marked leukocytosis, and elevated serum levels of C-reactive protein. The disease is caused by variants affecting the gene represented in this entry.