Entity Details

Primary name VPS28_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UK41
EntryNameVPS28_HUMAN
FullNameVacuolar protein sorting-associated protein 28 homolog
TaxID9606
Evidenceevidence at protein level
Length221
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesVPS28

GO terms

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GOName
GO:0000813 ESCRT I complex
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016197 endosomal transport
GO:0016236 macroautophagy
GO:0019058 viral life cycle
GO:0031397 negative regulation of protein ubiquitination
GO:0031902 late endosome membrane
GO:0036258 multivesicular body assembly
GO:0039702 viral budding via host ESCRT complex
GO:0043130 ubiquitin binding
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0043657 host cell
GO:0044877 protein-containing complex binding
GO:0045732 positive regulation of protein catabolic process
GO:0070062 extracellular exosome
GO:0075733 intracellular transport of virus
GO:2000397 positive regulation of ubiquitin-dependent endocytosis

Subcellular Location

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Subcellular Location
Cell membrane
Late endosome membrane

Domains

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DomainNameCategoryType
IPR007143 Vacuolar protein sorting-associated Vps28FamilyFamily
IPR017898 Vacuolar protein sorting-associated, VPS28, N-terminalDomainDomain
IPR017899 Vacuolar protein sorting-associated, VPS28, C-terminalDomainDomain
IPR037202 ESCRT assembly domainFamilyHomologous superfamily
IPR037206 VPS28, C-terminal domain superfamilyFamilyHomologous superfamily
IPR038358 VPS28, N-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

52 interactions

InteractorPartnerSourcesPublicationsLink
VPS28_HUMANUBC_HUMANBioGRID, MINT11916981 28190767 details
VPS28_HUMANASF1A_HUMANHPRD, IntAct16169070 details
VPS28_HUMANFABPH_HUMANHPRD, IntAct16169070 details
VPS28_HUMANGBRAP_HUMANHPRD, IntAct16169070 details
VPS28_HUMANTS101_HUMANBioGRID, HPRD, IntAct11134028 11916981 12663786 14505570 15218037 16189514 19060904 21757351 24284069 25416956 26186194 26344197 26871637 27609421 28514442 31515488 32296183 details
VPS28_HUMANSKIL_HUMANBioGRID, IntAct, MINT21516116 25416956 26871637 details
VPS28_HUMANVPS52_HUMANBioGRID, IntAct, MINT21516116 25416956 26871637 details
VPS28_HUMANSMN_HUMANBioGRID, IntAct, MINT21516116 25416956 26871637 details
VPS28_HUMANVP37B_HUMANBioGRID, HPRD, IntAct, MINT15218037 21516116 25416956 26186194 26344197 26871637 28514442 31515488 details
VPS28_HUMANCE57L_HUMANBioGRID, MINT21516116 details
VPS28_HUMANUSBP1_HUMANBioGRID, IntAct25416956 26871637 details
VPS28_HUMANTRI27_HUMANBioGRID, IntAct25416956 26871637 details
VPS28_HUMANRASF5_HUMANBioGRID, IntAct25416956 26871637 details
VPS28_HUMANHTF4_HUMANBioGRID, IntAct25416956 26871637 details
VPS28_HUMANGO45_HUMANBioGRID, IntAct25416956 26871637 details
VPS28_HUMANCARD9_HUMANBioGRID, IntAct25416956 26871637 details
VPS28_HUMANGOGA2_HUMANBioGRID, IntAct25416956 26871637 details
VPS28_HUMANMBIP1_HUMANBioGRID, IntAct25416956 26871637 details
VPS28_HUMANSAXO1_HUMANBioGRID, IntAct25416956 26871637 details
VPS28_HUMANTSNAX_HUMANBioGRID, IntAct32296183 details
VPS28_HUMANNXF1_HUMANBioGRID, IntAct32296183 details
VPS28_HUMANCC146_HUMANBioGRID, IntAct32296183 details
VPS28_HUMANAAPK2_HUMANBioGRID, IntAct32296183 details
VPS28_HUMANAAKB2_HUMANBioGRID, IntAct32296183 details
VPS28_HUMANSUOX_HUMANBioGRID, IntAct32296183 details
VPS28_HUMANABI2_HUMANBioGRID, IntAct32296183 details
VPS28_HUMANNRDE2_HUMANBioGRID, IntAct32296183 details
VPS28_HUMANSHC3_HUMANBioGRID, IntAct32296183 details
VPS28_HUMANBEX2_HUMANBioGRID, IntAct32296183 details
VPS28_HUMANCDK18_HUMANBioGRID, IntAct32296183 details
VPS28_HUMANUBP2_HUMANBioGRID, IntAct32296183 details
VPS28_HUMANLMO3_HUMANBioGRID, IntAct32296183 details
VPS28_HUMANGEM_HUMANBioGRID, IntAct32296183 details
VPS28_HUMANCOX5B_HUMANBioGRID, IntAct32296183 details
VPS28_HUMANVP37A_HUMANBioGRID, HPRD, IntAct15240819 15509564 21757351 26186194 28514442 31519728 details
VPS28_HUMANHD_HUMANBioGRID, IntAct, UniProt25959826 32814053 details
VPS28_HUMANPCNA_HUMANUniProt26030842 details
VPS28_HUMANVP37C_HUMANBioGRID15509564 21757351 details
VPS28_HUMANITF2_HUMANBioGRID25416956 details
VPS28_HUMANCBX5_HUMANBioGRID25416956 details
VPS28_HUMANTRI54_HUMANBioGRID25416956 details
VPS28_HUMANPNMA5_HUMANBioGRID25416956 details
VPS28_HUMANINCA1_HUMANBioGRID25416956 details
VPS28_HUMANUBAP1_HUMANBioGRID, IntAct21757351 22405001 24284069 26186194 28514442 31203368 details
VPS28_HUMANBCR_HUMANBioGRID16778200 details
VPS28_HUMANSNF8_HUMANBioGRID18539118 details
VPS28_HUMANVPS25_HUMANBioGRID18539118 21543492 details
VPS28_HUMANVPS36_HUMANBioGRID17215868 18539118 details
VPS28_HUMANALG2_HUMANBioGRID16004603 details
VPS28_HUMANRL40_HUMANHPRD11916981 details
VPS28_HUMANGLCI1_HUMANHPRD11591653 details
VPS28_HUMANPDC6I_HUMANHPRD12588984 details