Entity Details

Primary name HCN4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y3Q4
EntryNameHCN4_HUMAN
FullNamePotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
TaxID9606
Evidenceevidence at protein level
Length1203
SequenceStatuscomplete
DateCreated2003-02-28
DateModified2021-06-02

Ontological Relatives

GenesHCN4

GO terms

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GOName
GO:0002027 regulation of heart rate
GO:0003161 cardiac conduction system development
GO:0003163 sinoatrial node development
GO:0003254 regulation of membrane depolarization
GO:0005222 intracellular cAMP-activated cation channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005886 plasma membrane
GO:0006812 cation transport
GO:0006936 muscle contraction
GO:0008015 blood circulation
GO:0030552 cAMP binding
GO:0031226 intrinsic component of plasma membrane
GO:0034765 regulation of ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0042802 identical protein binding
GO:0048471 perinuclear region of cytoplasm
GO:0055117 regulation of cardiac muscle contraction
GO:0071320 cellular response to cAMP
GO:0071321 cellular response to cGMP
GO:0071805 potassium ion transmembrane transport
GO:0086012 membrane depolarization during cardiac muscle cell action potential
GO:0086015 SA node cell action potential
GO:0086041 voltage-gated potassium channel activity involved in SA node cell action potential depolarization
GO:0086046 membrane depolarization during SA node cell action potential
GO:0086091 regulation of heart rate by cardiac conduction
GO:0098719 sodium ion import across plasma membrane
GO:0098855 HCN channel complex
GO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction
GO:1990573 potassium ion import across plasma membrane

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000595 Cyclic nucleotide-binding domainDomainDomain
IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERGFamilyFamily
IPR005821 Ion transport domainDomainDomain
IPR013621 Ion transport N-terminalDomainDomain
IPR014710 RmlC-like jelly roll foldFamilyHomologous superfamily
IPR018488 Cyclic nucleotide-binding, conserved siteSiteConserved site
IPR018490 Cyclic nucleotide-binding-likeFamilyHomologous superfamily
IPR027359 Voltage-dependent channel domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
163800 OMIMSick sinus syndrome 2 (SSS2)The term 'sick sinus syndrome' encompasses a variety of conditions caused by sinus node dysfunction. The most common clinical manifestations are syncope, presyncope, dizziness, and fatigue. Electrocardiogram typically shows sinus bradycardia, sinus arrest, and/or sinoatrial block. Episodes of atrial tachycardias coexisting with sinus bradycardia ('tachycardia-bradycardia syndrome') are also common in this disorder. SSS occurs most often in the elderly associated with underlying heart disease or previous cardiac surgery, but can also occur in the fetus, infant, or child without heart disease or other contributing factors. SSS2 onset is in utero or at birth. The disease is caused by variants affecting the gene represented in this entry.
613123 OMIMBrugada syndrome 8 (BRGDA8)A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset. The gene represented in this entry may be involved in disease pathogenesis.