Entity Details

Primary name NOX1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y5S8
EntryNameNOX1_HUMAN
FullNameNADPH oxidase 1
TaxID9606
Evidenceevidence at protein level
Length564
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesNOX1

GO terms

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GOName
GO:0001525 angiogenesis
GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin
GO:0005244 voltage-gated ion channel activity
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0006739 NADP metabolic process
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0008217 regulation of blood pressure
GO:0008284 positive regulation of cell population proliferation
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0016175 superoxide-generating NAD(P)H oxidase activity
GO:0016477 cell migration
GO:0030054 cell junction
GO:0030198 extracellular matrix organization
GO:0031267 small GTPase binding
GO:0031343 positive regulation of cell killing
GO:0034765 regulation of ion transmembrane transport
GO:0042554 superoxide anion generation
GO:0042743 hydrogen peroxide metabolic process
GO:0042995 cell projection
GO:0043020 NADPH oxidase complex
GO:0045726 positive regulation of integrin biosynthetic process
GO:0045730 respiratory burst
GO:0046330 positive regulation of JNK cascade
GO:0046872 metal ion binding
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050661 NADP binding
GO:0051454 intracellular pH elevation
GO:0071455 cellular response to hyperoxia
GO:0072592 oxygen metabolic process
GO:1902177 positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1990451 cellular stress response to acidic pH

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection

Domains

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DomainNameCategoryType
IPR000778 Cytochrome b245, heavy chainFamilyFamily
IPR013112 FAD-binding 8DomainDomain
IPR013121 Ferric reductase, NAD binding domainDomainDomain
IPR013130 Ferric reductase transmembrane component-like domainDomainDomain
IPR017927 FAD-binding domain, ferredoxin reductase-typeDomainDomain
IPR017938 Riboflavin synthase-like beta-barrelFamilyHomologous superfamily
IPR029650 NADPH oxidase 1FamilyFamily
IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domainFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB09140 OxygenDrugbanksmall molecule