Entity Details

Primary name PLPL9_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO60733
EntryNamePLPL9_HUMAN
FullName85/88 kDa calcium-independent phospholipase A2
TaxID9606
Evidenceevidence at protein level
Length806
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesPLA2G6

GO terms

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GOName
GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity
GO:0004622 lysophospholipase activity
GO:0004623 phospholipase A2 activity
GO:0005516 calmodulin binding
GO:0005615 extracellular space
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006935 chemotaxis
GO:0016021 integral component of membrane
GO:0016290 palmitoyl-CoA hydrolase activity
GO:0019731 antibacterial humoral response
GO:0031143 pseudopodium
GO:0032049 cardiolipin biosynthetic process
GO:0034451 centriolar satellite
GO:0034638 phosphatidylcholine catabolic process
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0035965 cardiolipin acyl-chain remodeling
GO:0036151 phosphatidylcholine acyl-chain remodeling
GO:0036152 phosphatidylethanolamine acyl-chain remodeling
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042802 identical protein binding
GO:0046338 phosphatidylethanolamine catabolic process
GO:0046469 platelet activating factor metabolic process
GO:0046473 phosphatidic acid metabolic process
GO:0047499 calcium-independent phospholipase A2 activity
GO:0102545 phosphatidyl phospholipase B activity
GO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
GO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
GO:0102991 myristoyl-CoA hydrolase activity

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm
Mitochondrion

Domains

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DomainNameCategoryType
IPR002110 Ankyrin repeatRepeatRepeat
IPR002641 Patatin-like phospholipase domainDomainDomain
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipaseFamilyHomologous superfamily
IPR020683 Ankyrin repeat-containing domainDomainDomain
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
610217 OMIMNeurodegeneration with brain iron accumulation 2B (NBIA2B)A neurodegenerative disorder associated with iron accumulation in the brain, primarily in the basal ganglia. It is characterized by progressive extrapyramidal dysfunction leading to rigidity, dystonia, dysarthria and sensorimotor impairment. The disease is caused by variants affecting the gene represented in this entry.
256600 OMIMNeurodegeneration with brain iron accumulation 2A (NBIA2A)A neurodegenerative disease characterized by pathologic axonal swelling and spheroid bodies in the central nervous system. Onset is within the first 2 years of life with death by age 10 years. The disease is caused by variants affecting the gene represented in this entry.
612953 OMIMParkinson disease 14 (PARK14)An adult-onset progressive neurodegenerative disorder characterized by parkinsonism, dystonia, severe cognitive decline, cerebral and cerebellar atrophy and absent iron in the basal ganglia on magnetic resonance imaging. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB01103 QuinacrineDrugbanksmall molecule