Entity Details

Primary name TRPA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75762
EntryNameTRPA1_HUMAN
FullNameTransient receptor potential cation channel subfamily A member 1
TaxID9606
Evidenceevidence at protein level
Length1119
SequenceStatuscomplete
DateCreated2004-12-21
DateModified2021-06-02

Ontological Relatives

GenesTRPA1

GO terms

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GOName
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006811 ion transport
GO:0007166 cell surface receptor signaling pathway
GO:0009409 response to cold
GO:0010033 response to organic substance
GO:0014070 response to organic cyclic compound
GO:0015267 channel activity
GO:0015278 calcium-release channel activity
GO:0019233 sensory perception of pain
GO:0032421 stereocilium bundle
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042802 identical protein binding
GO:0048265 response to pain
GO:0050955 thermoception
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0050968 detection of chemical stimulus involved in sensory perception of pain
GO:0051289 protein homotetramerization
GO:0070588 calcium ion transmembrane transport
GO:0097604 temperature-gated cation channel activity

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR002110 Ankyrin repeatRepeatRepeat
IPR005821 Ion transport domainDomainDomain
IPR020683 Ankyrin repeat-containing domainDomainDomain
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00825 LevomentholDrugbanksmall molecule
DB01744 CamphorDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB11148 ButambenDrugbanksmall molecule
DB11345 (S)-camphorDrugbanksmall molecule
DB11755 TetrahydrocannabivarinDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule
DB14050 CannabidivarinDrugbanksmall molecule

Interactions

3 interactions