Entity Details

Primary name TRIO_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75962
EntryNameTRIO_HUMAN
FullNameTriple functional domain protein
TaxID9606
Evidenceevidence at protein level
Length3097
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesTRIO

GO terms

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GOName
GO:0004674 protein serine/threonine kinase activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007411 axon guidance
GO:0007417 central nervous system development
GO:0042995 cell projection
GO:0043065 positive regulation of apoptotic process
GO:0045599 negative regulation of fat cell differentiation
GO:0048812 neuron projection morphogenesis
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR000219 Dbl homology (DH) domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001251 CRAL-TRIO lipid binding domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR002017 Spectrin repeatRepeatRepeat
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR013098 Immunoglobulin I-setDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR018159 Spectrin/alpha-actininRepeatRepeat
IPR028570 Rho GDP/GTP exchange factor Kalirin/TRIOFamilyFamily
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR036865 CRAL-TRIO lipid binding domain superfamilyFamilyHomologous superfamily

Diseases

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