Entity Details

Primary name ABCBB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95342
EntryNameABCBB_HUMAN
FullNameBile salt export pump
TaxID9606
Evidenceevidence at protein level
Length1321
SequenceStatuscomplete
DateCreated2001-01-24
DateModified2021-06-02

Ontological Relatives

GenesABCB11

GO terms

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GOName
GO:0005524 ATP binding
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0006631 fatty acid metabolic process
GO:0006699 bile acid biosynthetic process
GO:0006855 drug transmembrane transport
GO:0008206 bile acid metabolic process
GO:0008559 ABC-type xenobiotic transporter activity
GO:0009986 cell surface
GO:0015125 bile acid transmembrane transporter activity
GO:0015126 canalicular bile acid transmembrane transporter activity
GO:0015432 ABC-type bile acid transporter activity
GO:0015721 bile acid and bile salt transport
GO:0015722 canalicular bile acid transport
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0016567 protein ubiquitination
GO:0017144 drug metabolic process
GO:0031998 regulation of fatty acid beta-oxidation
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0042632 cholesterol homeostasis
GO:0046581 intercellular canaliculus
GO:0046618 drug export
GO:0046691 intracellular canaliculus
GO:0055037 recycling endosome
GO:0055038 recycling endosome membrane
GO:0055085 transmembrane transport
GO:0055088 lipid homeostasis
GO:0055091 phospholipid homeostasis
GO:0070062 extracellular exosome
GO:0120189 positive regulation of bile acid secretion
GO:1904251 regulation of bile acid metabolic process

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell membrane
Endosome
Recycling endosome membrane

Domains

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DomainNameCategoryType
IPR003439 ABC transporter-like, ATP-binding domainDomainDomain
IPR003593 AAA+ ATPase domainDomainDomain
IPR011527 ABC transporter type 1, transmembrane domainDomainDomain
IPR017871 ABC transporter-like, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR030278 Bile salt export pumpFamilyFamily
IPR036640 ABC transporter type 1, transmembrane domain superfamilyFamilyHomologous superfamily
IPR039421 Type 1 protein exporterFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00091 CyclosporineDrugbanksmall molecule
DB00171 ATPDrugbanksmall molecule
DB00175 PravastatinDrugbanksmall molecule
DB00176 FluvoxamineDrugbanksmall molecule
DB00197 TroglitazoneDrugbanksmall molecule
DB00199 ErythromycinDrugbanksmall molecule
DB00206 ReserpineDrugbanksmall molecule
DB00220 NelfinavirDrugbanksmall molecule
DB00222 GlimepirideDrugbanksmall molecule
DB00224 IndinavirDrugbanksmall molecule
DB00227 LovastatinDrugbanksmall molecule
DB00243 RanolazineDrugbanksmall molecule
DB00255 DiethylstilbestrolDrugbanksmall molecule
DB00257 ClotrimazoleDrugbanksmall molecule
DB00270 IsradipineDrugbanksmall molecule
DB00275 OlmesartanDrugbanksmall molecule
DB00301 FlucloxacillinDrugbanksmall molecule
DB00328 IndomethacinDrugbanksmall molecule
DB00335 AtenololDrugbanksmall molecule
DB00342 TerfenadineDrugbanksmall molecule
DB00390 DigoxinDrugbanksmall molecule
DB00396 ProgesteroneDrugbanksmall molecule
DB00412 RosiglitazoneDrugbanksmall molecule
DB00421 SpironolactoneDrugbanksmall molecule
DB00439 CerivastatinDrugbanksmall molecule
DB00455 LoratadineDrugbanksmall molecule
DB00477 ChlorpromazineDrugbanksmall molecule
DB00482 CelecoxibDrugbanksmall molecule
DB00501 CimetidineDrugbanksmall molecule
DB00503 RitonavirDrugbanksmall molecule
DB00541 VincristineDrugbanksmall molecule
DB00559 BosentanDrugbanksmall molecule
DB00570 VinblastineDrugbanksmall molecule
DB00572 AtropineDrugbanksmall molecule
DB00586 DiclofenacDrugbanksmall molecule
DB00619 ImatinibDrugbanksmall molecule
DB00622 NicardipineDrugbanksmall molecule
DB00625 EfavirenzDrugbanksmall molecule
DB00637 AstemizoleDrugbanksmall molecule
DB00641 SimvastatinDrugbanksmall molecule
DB00675 TamoxifenDrugbanksmall molecule
DB00678 LosartanDrugbanksmall molecule
DB00693 FluoresceinDrugbanksmall molecule
DB00694 DaunorubicinDrugbanksmall molecule
DB00698 NitrofurantoinDrugbanksmall molecule
DB00788 NaproxenDrugbanksmall molecule
DB00822 DisulfiramDrugbanksmall molecule
DB00833 CefaclorDrugbanksmall molecule
DB00834 MifepristoneDrugbanksmall molecule
DB00908 QuinidineDrugbanksmall molecule
DB00911 TinidazoleSwissprotsmall molecule
DB00912 RepaglinideDrugbanksmall molecule
DB00932 TipranavirDrugbanksmall molecule
DB00966 TelmisartanDrugbanksmall molecule
DB00973 EzetimibeDrugbanksmall molecule
DB00975 DipyridamoleDrugbanksmall molecule
DB00977 EthinylestradiolDrugbanksmall molecule
DB00997 DoxorubicinDrugbanksmall molecule
DB01015 SulfamethoxazoleDrugbanksmall molecule
DB01016 GlyburideDrugbanksmall molecule
DB01023 FelodipineDrugbanksmall molecule
DB01026 KetoconazoleDrugbanksmall molecule
DB01039 FenofibrateDrugbanksmall molecule
DB01045 RifampicinDrugbanksmall molecule
DB01054 NitrendipineDrugbanksmall molecule
DB01067 GlipizideDrugbanksmall molecule
DB01072 AtazanavirDrugbanksmall molecule
DB01076 AtorvastatinDrugbanksmall molecule
DB01098 RosuvastatinDrugbanksmall molecule
DB01115 NifedipineDrugbanksmall molecule
DB01118 AmiodaroneDrugbanksmall molecule
DB01138 SulfinpyrazoneDrugbanksmall molecule
DB01149 NefazodoneDrugbanksmall molecule
DB01165 OfloxacinDrugbanksmall molecule
DB01174 PhenobarbitalDrugbanksmall molecule
DB01211 ClarithromycinDrugbanksmall molecule
DB01222 BudesonideDrugbanksmall molecule
DB01229 PaclitaxelDrugbanksmall molecule
DB01232 SaquinavirDrugbanksmall molecule
DB01234 DexamethasoneDrugbanksmall molecule
DB01586 Ursodeoxycholic acidDrugbanksmall molecule
DB01601 LopinavirDrugbanksmall molecule
DB02123 Glycochenodeoxycholic AcidDrugbanksmall molecule
DB02659 Cholic AcidDrugbanksmall molecule
DB02703 Fusidic acidDrugbanksmall molecule
DB03619 Deoxycholic acidDrugbanksmall molecule
DB04348 Taurocholic acidDrugbanksmall molecule
DB05804 Prasterone sulfateSwissprotsmall molecule
DB05990 Obeticholic acidDrugbanksmall molecule
DB06290 SimeprevirDrugbanksmall molecule
DB08860 PitavastatinDrugbanksmall molecule
DB09078 LenvatinibDrugbanksmall molecule
DB09374 Indocyanine green acid formSwissprotsmall molecule
DB12070 LetermovirDrugbanksmall molecule
DB12319 BenzbromaroneDrugbanksmall molecule
DB12712 PilsicainideSwissprotsmall molecule
DB13345 DihydroergocristineDrugbanksmall molecule
DB13751 Glycyrrhizic acidDrugbanksmall molecule
DB14057 ValinomycinSwissprotsmall molecule
DB14649 Dexamethasone acetateDrugbanksmall molecule
DB14761 RemdesivirDrugbanksmall molecule
DB15719 Belantamab mafodotinDrugbankbiotech
DB15822 PralsetinibDrugbanksmall molecule