Entity Details

Primary name GGPPS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95749
EntryNameGGPPS_HUMAN
FullNameGeranylgeranyl pyrophosphate synthase
TaxID9606
Evidenceevidence at protein level
Length300
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesGGPS1

GO terms

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GOName
GO:0004161 dimethylallyltranstransferase activity
GO:0004311 farnesyltranstransferase activity
GO:0004337 geranyltranstransferase activity
GO:0004659 prenyltransferase activity
GO:0005829 cytosol
GO:0006695 cholesterol biosynthetic process
GO:0006720 isoprenoid metabolic process
GO:0008299 isoprenoid biosynthetic process
GO:0019216 regulation of lipid metabolic process
GO:0033384 geranyl diphosphate biosynthetic process
GO:0033386 geranylgeranyl diphosphate biosynthetic process
GO:0042802 identical protein binding
GO:0045337 farnesyl diphosphate biosynthetic process
GO:0046872 metal ion binding

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000092 Polyprenyl synthetaseFamilyFamily
IPR008949 Isoprenoid synthase domain superfamilyFamilyHomologous superfamily
IPR033749 Polyprenyl synthetase, conserved siteSiteConserved site

Diseases

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Drugs

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DrugNameSourceType
DB00282 Pamidronic acidDrugbanksmall molecule
DB00399 Zoledronic acidDrugbanksmall molecule
DB00710 IbandronateDrugbanksmall molecule
DB02552 Geranyl DiphosphateDrugbanksmall molecule
DB04695 Farnesyl thiopyrophosphateDrugbanksmall molecule
DB04714 ISOPENTENYL PYROPHOSPHATEDrugbanksmall molecule
DB06548 Minodronic acidDrugbanksmall molecule
DB06830 (1-HYDROXYHEPTANE-1,1-DIYL)BIS(PHOSPHONIC ACID)Drugbanksmall molecule
DB06931 (1-HYDROXYNONANE-1,1-DIYL)BIS(PHOSPHONIC ACID)Drugbanksmall molecule
DB07221 (2,2-DIPHOSPHONOETHYL)(DODECYL)DIMETHYLPHOSPHONIUMDrugbanksmall molecule
DB07410 [2-(3-DIBENZOFURAN-4-YL-PHENYL)-1-HYDROXY-1-PHOSPHONO-ETHYL]-PHOSPHONIC ACIDDrugbanksmall molecule
DB07780 Farnesyl diphosphateDrugbanksmall molecule
DB07841 Geranylgeranyl diphosphateDrugbanksmall molecule
DB07873 Lauryl alcohol diphosphonic acidDrugbanksmall molecule
DB08529 (6E,11E)-HEPTADECA-6,11-DIENE-9,9-DIYLBIS(PHOSPHONIC ACID)Drugbanksmall molecule

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
GGPPS_HUMANATOX1_HUMANBioGRID, IntAct25416956 details
GGPPS_HUMANGGPPS_HUMANBioGRID, IntAct25416956 31515488 32296183 details
GGPPS_HUMANSDCB1_HUMANBioGRID, IntAct32296183 details