Entity Details

Primary name DYR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP00374
EntryNameDYR_HUMAN
FullNameDihydrofolate reductase
TaxID9606
Evidenceevidence at protein level
Length187
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesDHFR

GO terms

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GOName
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000900 translation repressor activity, mRNA regulatory element binding
GO:0003729 mRNA binding
GO:0004146 dihydrofolate reductase activity
GO:0005542 folic acid binding
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006545 glycine biosynthetic process
GO:0006729 tetrahydrobiopterin biosynthetic process
GO:0006730 one-carbon metabolic process
GO:0008144 drug binding
GO:0017148 negative regulation of translation
GO:0031103 axon regeneration
GO:0031427 response to methotrexate
GO:0046452 dihydrofolate metabolic process
GO:0046653 tetrahydrofolate metabolic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0046655 folic acid metabolic process
GO:0050661 NADP binding
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051870 methotrexate binding
GO:0070402 NADPH binding
GO:1990825 sequence-specific mRNA binding
GO:2000121 regulation of removal of superoxide radicals

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion

Domains

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DomainNameCategoryType
IPR001796 Dihydrofolate reductase domainDomainDomain
IPR012259 Dihydrofolate reductaseFamilyFamily
IPR017925 Dihydrofolate reductase conserved siteSiteConserved site
IPR024072 Dihydrofolate reductase-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB00158 Folic acidDrugbanksmall molecule
DB00205 PyrimethamineDrugbanksmall molecule
DB00555 LamotrigineDrugbanksmall molecule
DB00563 MethotrexateDrugbanksmall molecule
DB00642 PemetrexedDrugbanksmall molecule
DB00798 GentamicinDrugbanksmall molecule
DB01131 ProguanilDrugbanksmall molecule
DB01157 TrimetrexateDrugbanksmall molecule
DB02104 2,4-Diamino-5-Methyl-6-[(3,4,5-Trimethoxy-N-Methylanilino)Methyl]Pyrido[2,3-D]PyrimidineDrugbanksmall molecule
DB02427 2,4-Diamino-6-[N-(2',5'-Dimethoxybenzyl)-N-Methylamino]QuinazolineDrugbanksmall molecule
DB02559 6-(Octahydro-1h-Indol-1-Ylmethyl)Decahydroquinazoline-2,4-DiamineDrugbanksmall molecule
DB02583 N6-(2,5-Dimethoxy-Benzyl)-N6-Methyl-Pyrido[2,3-D]Pyrimidine-2,4,6-TriamineDrugbanksmall molecule
DB02919 2,4-Diamino-6-[N-(3',4',5'-Trimethoxybenzyl)-N-Methylamino]Pyrido[2,3-D]PyrimidineDrugbanksmall molecule
DB03060 Sri-9662Drugbanksmall molecule
DB03125 2,4-Diamino-5-(3,4,5-Trimethoxy-Benzyl)-Pyrimidin-1-IumDrugbanksmall molecule
DB03351 Sri-9439Drugbanksmall molecule
DB03461 Nicotinamide adenine dinucleotide phosphateDrugbanksmall molecule
DB03695 PiritreximDrugbanksmall molecule
DB03886 BiopterinDrugbanksmall molecule
DB03987 2,4-Diamino-6-[N-(3',5'-Dimethoxybenzyl)-N-Methylamino]Pyrido[2,3-D]PyrimidineDrugbanksmall molecule
DB06358 IclaprimDrugbanksmall molecule
DB06813 PralatrexateDrugbanksmall molecule
DB07140 5-[(3R)-3-(5-methoxybiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamineDrugbanksmall molecule
DB07141 5-[(3R)-3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamineDrugbanksmall molecule
DB07142 5-[(3R)-3-(5-methoxy-3',5'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamineDrugbanksmall molecule
DB07144 5-[(3R)-3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamineDrugbanksmall molecule
DB08234 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamineDrugbanksmall molecule
DB08406 [N-(2,4-DIAMINOPTERIDIN-6-YL)-METHYL]-DIBENZ[B,F]AZEPINEDrugbanksmall molecule
DB08448 (4aS)-5-[(2,4-diaminopteridin-6-yl)methyl]-4a,5-dihydro-2H-dibenzo[b,f]azepin-8-olDrugbanksmall molecule
DB08642 (2R,6S)-6-{[methyl(3,4,5-trimethoxyphenyl)amino]methyl}-1,2,5,6,7,8-hexahydroquinazoline-2,4-diamineDrugbanksmall molecule
DB08878 AminopterinSwissprotsmall molecule