Entity Details

Primary name IGHG2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01859
EntryNameIGHG2_HUMAN
FullNameImmunoglobulin heavy constant gamma 2
TaxID9606
Evidenceevidence at protein level
Length326
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0003823 antigen binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006910 phagocytosis, recognition
GO:0006911 phagocytosis, engulfment
GO:0006956 complement activation
GO:0006958 complement activation, classical pathway
GO:0008228 opsonization
GO:0009897 external side of plasma membrane
GO:0018149 peptide cross-linking
GO:0030449 regulation of complement activation
GO:0034987 immunoglobulin receptor binding
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042571 immunoglobulin complex, circulating
GO:0042742 defense response to bacterium
GO:0045087 innate immune response
GO:0050853 B cell receptor signaling pathway
GO:0050871 positive regulation of B cell activation
GO:0070062 extracellular exosome
GO:0072562 blood microparticle

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR003006 Immunoglobulin/major histocompatibility complex, conserved siteSiteConserved site
IPR003597 Immunoglobulin C1-setDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB02854 AetiocholanoloneDrugbanksmall molecule
DB04688 MethylecgonineDrugbanksmall molecule
DB07329 1-[N-4'-NITROBENZYL-N-4'-CARBOXYBUTYLAMINO]METHYLPHOSPHONIC ACIDDrugbanksmall molecule
DB07375 EtiocholanedioneDrugbanksmall molecule
DB08323 3-OXO-N-[(3S)-2-OXOPYRROLIDIN-3-YL]DODECANAMIDEDrugbanksmall molecule
DB08409 4-NITRO-BENZYLPHOSPHONOBUTANOYL-GLYCINEDrugbanksmall molecule
DB08510 5-ALPHA-PREGNANE-3-BETA-OL-HEMISUCCINATEDrugbanksmall molecule
DB08547 PROGESTERONE-11-ALPHA-OL-HEMISUCCINATEDrugbanksmall molecule
DB08618 3-(HYDROXY-PHENYL-PHOSPHINOYLOXY)-8-METHYL-8-AZA-BICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID METHYL ESTERDrugbanksmall molecule
DB15258 ImlifidaseDrugbankbiotech

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
IGHG2_HUMANUSF2_HUMANIntAct17353931 details
IGHG2_HUMANAK1A1_HUMANIntAct28514442 details