Entity Details

Primary name FIBA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP02671
EntryNameFIBA_HUMAN
FullNameFibrinogen alpha chain
TaxID9606
Evidenceevidence at protein level
Length866
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesFGA

GO terms

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GOName
GO:0002224 toll-like receptor signaling pathway
GO:0002250 adaptive immune response
GO:0002576 platelet degranulation
GO:0005102 signaling receptor binding
GO:0005198 structural molecule activity
GO:0005201 extracellular matrix structural constituent
GO:0005576 extracellular region
GO:0005577 fibrinogen complex
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0007160 cell-matrix adhesion
GO:0007596 blood coagulation
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0030198 extracellular matrix organization
GO:0031091 platelet alpha granule
GO:0031093 platelet alpha granule lumen
GO:0031639 plasminogen activation
GO:0034116 positive regulation of heterotypic cell-cell adhesion
GO:0034622 cellular protein-containing complex assembly
GO:0042730 fibrinolysis
GO:0043152 induction of bacterial agglutination
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0045087 innate immune response
GO:0045202 synapse
GO:0045907 positive regulation of vasoconstriction
GO:0045921 positive regulation of exocytosis
GO:0046872 metal ion binding
GO:0050714 positive regulation of protein secretion
GO:0051258 protein polymerization
GO:0051592 response to calcium ion
GO:0062023 collagen-containing extracellular matrix
GO:0065003 protein-containing complex assembly
GO:0070062 extracellular exosome
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070527 platelet aggregation
GO:0072377 blood coagulation, common pathway
GO:0072378 blood coagulation, fibrin clot formation
GO:0072562 blood microparticle
GO:0090277 positive regulation of peptide hormone secretion
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1903561 extracellular vesicle
GO:1990000 amyloid fibril formation
GO:2000261 negative regulation of blood coagulation, common pathway
GO:2000352 negative regulation of endothelial cell apoptotic process

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domainDomainDomain
IPR012290 Fibrinogen, alpha/beta/gamma chain, coiled coil domainDomainDomain
IPR020837 Fibrinogen, conserved siteSiteConserved site
IPR021996 Fibrinogen alpha C domainDomainDomain
IPR036056 Fibrinogen-like, C-terminalFamilyHomologous superfamily
IPR037579 Fibrinogen alpha chainFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00009 AlteplaseDrugbankbiotech
DB00015 ReteplaseDrugbankbiotech
DB00029 AnistreplaseDrugbankbiotech
DB00031 TenecteplaseDrugbankbiotech
DB00364 SucralfateDrugbanksmall molecule
DB01593 ZincDrugbanksmall molecule
DB04919 AlfimepraseDrugbankbiotech
DB05099 AncrodDrugbankbiotech
DB05675 EP-2104RDrugbankbiotech
DB06245 LanoteplaseDrugbankbiotech
DB11300 ThrombinDrugbankbiotech
DB11311 ProthrombinDrugbankbiotech
DB11571 Human thrombinDrugbankbiotech
DB11572 Thrombin alfaDrugbankbiotech
DB13151 Anti-inhibitor coagulant complexDrugbankbiotech
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

35 interactions

InteractorPartnerSourcesPublicationsLink
FIBA_HUMANPRC2A_HUMANBioGRID, HPRD, IntAct14667819 details
FIBA_HUMANK1C18_HUMANIntAct10954706 details
FIBA_HUMANKLK6_HUMANIntAct12878203 details
FIBA_HUMANPASK_HUMANMINT21418524 details
FIBA_HUMANTFP11_HUMANBioGRID, IntAct32296183 details
FIBA_HUMAN3BP1_HUMANBioGRID, IntAct32296183 details
FIBA_HUMANTMM43_HUMANBioGRID, IntAct32296183 details
FIBA_HUMANEXOC5_HUMANBioGRID, IntAct32296183 details
FIBA_HUMANSTX2_HUMANBioGRID, IntAct32296183 details
FIBA_HUMANTPM3_HUMANBioGRID, IntAct32296183 details
FIBA_HUMANTPM1_HUMANBioGRID, IntAct32296183 details
FIBA_HUMANSTX1B_HUMANBioGRID, IntAct32296183 details
FIBA_HUMANFA20C_HUMANIntAct22582013 26091039 details
FIBA_HUMANLAMP2_HUMANIntAct32814053 details
FIBA_HUMANSHLB1_HUMANIntAct32814053 details
FIBA_HUMANSODC_HUMANIntAct32814053 details
FIBA_HUMANTPA_HUMANBioGRID, HPRD11170397 3088041 details
FIBA_HUMANNID1_HUMANBioGRID, HPRD1680863 details
FIBA_HUMANHRG_HUMANBioGRID, HPRD9276466 details
FIBA_HUMANTSP1_HUMANBioGRID, HPRD9867861 details
FIBA_HUMANCADH5_HUMANBioGRID, HPRD11900554 details
FIBA_HUMANUBC_HUMANBioGRID23314748 details
FIBA_HUMANITA2B_HUMANBioGRID, HPRD11460491 9058485 details
FIBA_HUMANITB3_HUMANBioGRID, HPRD11460491 9058485 details
FIBA_HUMANMEOX2_HUMANBioGRID26871637 details
FIBA_HUMANATRAP_HUMANBioGRID26871637 details
FIBA_HUMANA4_HUMANBioGRID27221710 details
FIBA_HUMANSYC1L_HUMANBioGRID32296183 details
FIBA_HUMANLRP1B_HUMANBioGRID21420681 details
FIBA_HUMANHS90A_HUMANBioGRID31273033 details
FIBA_HUMANTHRB_HUMANBioGRID, HPRD, IntAct1587268 2133223 25241761 2742826 details
FIBA_HUMANF13A_HUMANBioGRID, HPRD10956659 details
FIBA_HUMANFIBA_HUMANBioGRID, HPRD9689040 details
FIBA_HUMANA2AP_HUMANHPRD10963790 14751930 details
FIBA_HUMANIPSP_HUMANHPRD8384496 8589203 details