Entity Details

Primary name FETUA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP02765
EntryNameFETUA_HUMAN
FullNameAlpha-2-HS-glycoprotein
TaxID9606
Evidenceevidence at protein level
Length367
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesAHSG

GO terms

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GOName
GO:0001501 skeletal system development
GO:0002576 platelet degranulation
GO:0004866 endopeptidase inhibitor activity
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005794 Golgi apparatus
GO:0006907 pinocytosis
GO:0006953 acute-phase response
GO:0010951 negative regulation of endopeptidase activity
GO:0019210 kinase inhibitor activity
GO:0030500 regulation of bone mineralization
GO:0030502 negative regulation of bone mineralization
GO:0031012 extracellular matrix
GO:0031093 platelet alpha granule lumen
GO:0034774 secretory granule lumen
GO:0043312 neutrophil degranulation
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0050727 regulation of inflammatory response
GO:0050766 positive regulation of phagocytosis
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0072562 blood microparticle

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000010 Cystatin domainDomainDomain
IPR001363 Proteinase inhibitor I25C, fetuin, conserved siteSiteConserved site
IPR025760 Fetuin-A-type cystatin domainDomainDomain

Diseases

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Disease IDSourceNameDescription
203650 OMIMAlopecia-mental retardation syndrome 1 (APMR1)A rare autosomal recessive form of alopecia. APMR1 patients show loss of hair on the scalp, absence of eyebrows, eyelashes, axillary and pubic hair, and mild to severe mental retardation. The disease may be caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule