Entity Details

Primary name ALDH2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05091
EntryNameALDH2_HUMAN
FullNameAldehyde dehydrogenase, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length517
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesALDH2

GO terms

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GOName
GO:0004029 aldehyde dehydrogenase (NAD+) activity
GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity
GO:0005759 mitochondrial matrix
GO:0005975 carbohydrate metabolic process
GO:0006066 alcohol metabolic process
GO:0006068 ethanol catabolic process
GO:0006069 ethanol oxidation
GO:0009055 electron transfer activity
GO:0043878 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
GO:0051287 NAD binding
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Mitochondrion matrix

Domains

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DomainNameCategoryType
IPR015590 Aldehyde dehydrogenase domainDomainDomain
IPR016160 Aldehyde dehydrogenase, cysteine active siteSiteConserved site
IPR016161 Aldehyde/histidinol dehydrogenaseFamilyHomologous superfamily
IPR016162 Aldehyde dehydrogenase, N-terminalFamilyHomologous superfamily
IPR016163 Aldehyde dehydrogenase, C-terminalFamilyHomologous superfamily
IPR029510 Aldehyde dehydrogenase, glutamic acid active siteSiteConserved site

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB00435 Nitric OxideDrugbanksmall molecule
DB00536 GuanidineDrugbanksmall molecule
DB00727 NitroglycerinDrugbanksmall molecule
DB00822 DisulfiramDrugbanksmall molecule
DB01612 Amyl NitriteDrugbanksmall molecule
DB02115 DaidzinDrugbanksmall molecule
DB04381 CrotonaldehydeDrugbanksmall molecule
DB06154 Pentaerythritol tetranitrateDrugbanksmall molecule
DB06770 Benzyl alcoholSwissprotsmall molecule
DB09117 ParaldehydeSwissprotsmall molecule