Entity Details

Primary name PGFRB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP09619
EntryNamePGFRB_HUMAN
FullNamePlatelet-derived growth factor receptor beta
TaxID9606
Evidenceevidence at protein level
Length1106
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesPDGFRB

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004992 platelet activating factor receptor activity
GO:0005017 platelet-derived growth factor-activated receptor activity
GO:0005019 platelet-derived growth factor beta-receptor activity
GO:0005102 signaling receptor binding
GO:0005161 platelet-derived growth factor receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0006024 glycosaminoglycan biosynthetic process
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007568 aging
GO:0008284 positive regulation of cell population proliferation
GO:0008584 male gonad development
GO:0009636 response to toxic substance
GO:0009986 cell surface
GO:0010863 positive regulation of phospholipase C activity
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014911 positive regulation of smooth muscle cell migration
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0016477 cell migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019838 growth factor binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030335 positive regulation of cell migration
GO:0031226 intrinsic component of plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0032355 response to estradiol
GO:0032516 positive regulation of phosphoprotein phosphatase activity
GO:0032526 response to retinoic acid
GO:0032956 regulation of actin cytoskeleton organization
GO:0032967 positive regulation of collagen biosynthetic process
GO:0033674 positive regulation of kinase activity
GO:0034405 response to fluid shear stress
GO:0035025 positive regulation of Rho protein signal transduction
GO:0035441 cell migration involved in vasculogenesis
GO:0035789 metanephric mesenchymal cell migration
GO:0035791 platelet-derived growth factor receptor-beta signaling pathway
GO:0035793 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
GO:0035909 aorta morphogenesis
GO:0038085 vascular endothelial growth factor binding
GO:0038091 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0042060 wound healing
GO:0042542 response to hydrogen peroxide
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043202 lysosomal lumen
GO:0043231 intracellular membrane-bounded organelle
GO:0043235 receptor complex
GO:0043406 positive regulation of MAP kinase activity
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0043627 response to estrogen
GO:0045840 positive regulation of mitotic nuclear division
GO:0046488 phosphatidylinositol metabolic process
GO:0046777 protein autophosphorylation
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048146 positive regulation of fibroblast proliferation
GO:0048407 platelet-derived growth factor binding
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048839 inner ear development
GO:0050921 positive regulation of chemotaxis
GO:0051897 positive regulation of protein kinase B signaling
GO:0055003 cardiac myofibril assembly
GO:0055093 response to hyperoxia
GO:0060326 cell chemotaxis
GO:0060437 lung growth
GO:0060981 cell migration involved in coronary angiogenesis
GO:0061298 retina vasculature development in camera-type eye
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071670 smooth muscle cell chemotaxis
GO:0072075 metanephric mesenchyme development
GO:0072262 metanephric glomerular mesangial cell proliferation involved in metanephros development
GO:0072277 metanephric glomerular capillary formation
GO:0072278 metanephric comma-shaped body morphogenesis
GO:0072284 metanephric S-shaped body morphogenesis
GO:0090280 positive regulation of calcium ion import
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000491 positive regulation of hepatic stellate cell activation
GO:2000573 positive regulation of DNA biosynthetic process

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasmic vesicle
Lysosome lumen

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001824 Tyrosine-protein kinase, receptor class III, conserved siteSiteConserved site
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013098 Immunoglobulin I-setDomainDomain
IPR013151 ImmunoglobulinDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR027288 Platelet-derived growth factor receptor betaFamilyFamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00102 BecaplerminDrugbankbiotech
DB00398 SorafenibDrugbanksmall molecule
DB00619 ImatinibDrugbanksmall molecule
DB01254 DasatinibDrugbanksmall molecule
DB01268 SunitinibDrugbanksmall molecule
DB05014 XL999Drugbanksmall molecule
DB05146 XL820Drugbanksmall molecule
DB06589 PazopanibDrugbanksmall molecule
DB06595 MidostaurinDrugbanksmall molecule
DB08896 RegorafenibDrugbanksmall molecule
DB09079 NintedanibDrugbanksmall molecule
DB09221 PolaprezincDrugbanksmall molecule
DB09283 TrapidilDrugbanksmall molecule
DB10770 Foreskin fibroblast (neonatal)Drugbankbiotech
DB12010 FostamatinibDrugbanksmall molecule
DB12147 ErdafitinibDrugbanksmall molecule
DB12978 PexidartinibDrugbanksmall molecule
DB14840 RipretinibDrugbanksmall molecule
DB15822 PralsetinibDrugbanksmall molecule

Interactions

112 interactions

InteractorPartnerSourcesPublicationsLink
PGFRB_HUMANKR412_HUMANBioGRID, HPRD, IntAct16189514 details
PGFRB_HUMANNHRF2_HUMANBioGRID, MINT16456542 details
PGFRB_HUMANNHRF1_HUMANBioGRID, HPRD, IntAct, MINT11046132 16456542 23397142 24012959 details
PGFRB_HUMANPTEN_HUMANBioGRID, IntAct, MINT14718524 16456542 24012959 25241761 details
PGFRB_HUMANPDGFB_HUMANBioGRID, DIP, HPRD, IntAct10806482 11297552 11903042 17981115 18593464 20534510 20577048 7679113 details
PGFRB_HUMANPTN1_HUMANHPRD, IntAct, MINT12614164 19167335 7545675 9355745 details
PGFRB_HUMANPTPRC_HUMANIntAct19167335 details
PGFRB_HUMANPTPRK_HUMANIntAct19167335 details
PGFRB_HUMANPTPRE_HUMANIntAct19167335 details
PGFRB_HUMANPTPRG_HUMANIntAct19167335 details
PGFRB_HUMANPTPRB_HUMANIntAct19167335 details
PGFRB_HUMANPTPRJ_HUMANHPRD, IntAct, MINT10821867 12062403 19167335 details
PGFRB_HUMANPTPRO_HUMANIntAct19167335 details
PGFRB_HUMANPTPRR_HUMANIntAct19167335 details
PGFRB_HUMANPTN6_HUMANBioGRID, IntAct19167335 9452499 details
PGFRB_HUMANPTN12_HUMANIntAct, MINT12614164 19167335 21376233 details
PGFRB_HUMANPTN22_HUMANIntAct19167335 details
PGFRB_HUMANP85A_HUMANBioGRID, HPRD, IntAct, MINT10697503 10752619 11710529 11896612 1314164 1330535 1372092 15377662 16135792 19864249 28514442 7531698 7536927 7678051 7680644 7692233 8382612 8388538 8564419 8670861 9153411 details
PGFRB_HUMANPLCG1_HUMANBioGRID, DIP, HPRD, IntAct, MINT11896612 1396585 15641795 22974441 23063561 23397142 7678051 8443409 9797459 details
PGFRB_HUMANCRK_HUMANBioGRID, HPRD, MINT10733900 details
PGFRB_HUMANNCK2_HUMANBioGRID, HPRD, MINT10026169 11027258 9737977 details
PGFRB_HUMANFYN_HUMANBioGRID, HPRD, MINT1661130 1696179 7520528 7685273 7687537 9425276 details
PGFRB_HUMANPTN11_HUMANBioGRID, HPRD, IntAct, MINT11266449 12614164 12681492 23397142 23922991 7530043 7688466 7691811 8041791 8119896 8183548 8538796 details
PGFRB_HUMANSRC_HUMANBioGRID, HPRD, MINT17158602 17785434 18315570 2173144 7678051 7685273 details
PGFRB_HUMANGRB2_HUMANBioGRID, HPRD, MINT10026169 7935391 9362449 details
PGFRB_HUMANGRB7_HUMANBioGRID, HPRD, MINT8940081 details
PGFRB_HUMANRAF1_HUMANBioGRID, HPRD, IntAct23397142 2475255 details
PGFRB_HUMANPGFRA_HUMANBioGRID, HPRD, IntAct11331882 1847074 2161888 2542288 28514442 7523122 details
PGFRB_HUMANTRIP6_HUMANBioGRID, IntAct25416956 details
PGFRB_HUMANKLH12_HUMANBioGRID, IntAct25416956 32296183 details
PGFRB_HUMANK1H1_HUMANBioGRID, IntAct32296183 details
PGFRB_HUMANKR123_HUMANBioGRID, IntAct32296183 details
PGFRB_HUMANKPRP_HUMANBioGRID, IntAct32296183 details
PGFRB_HUMANKRT34_HUMANBioGRID, IntAct32296183 details
PGFRB_HUMANCEP76_HUMANBioGRID, IntAct32296183 details
PGFRB_HUMANKR109_HUMANBioGRID, IntAct32296183 details
PGFRB_HUMANPGFRB_HUMANBioGRID, DIP, HPRD10391677 10821867 11046132 12062403 18505839 7523122 7935391 8195171 8617789 8940081 9207175 9815748 details
PGFRB_HUMANTPTE_HUMANBioGRID, MINT28065597 details
PGFRB_HUMANPPM1L_HUMANBioGRID, MINT28065597 details
PGFRB_HUMANA4_HUMANIntAct32814053 details
PGFRB_HUMANVAV_HUMANBioGRID10938113 22974441 details
PGFRB_HUMANGRB14_HUMANBioGRID, HPRD8647858 details
PGFRB_HUMANCAV1_HUMANBioGRID10066366 details
PGFRB_HUMANCAV3_HUMANBioGRID10066366 details
PGFRB_HUMANSNX1_HUMANBioGRID, HPRD9819414 details
PGFRB_HUMANSNX2_HUMANBioGRID, HPRD9819414 details
PGFRB_HUMANNEDD4_HUMANBioGRID19953087 details
PGFRB_HUMANACK1_HUMANBioGRID19815557 25257795 details
PGFRB_HUMANFGFR1_HUMANBioGRID19339244 details
PGFRB_HUMANABL1_HUMANBioGRID19275932 details
PGFRB_HUMANABL2_HUMANBioGRID19275932 details
PGFRB_HUMANSYGP1_HUMANBioGRID, HPRD1374684 7678051 details
PGFRB_HUMANKS6B2_HUMANBioGRID16640565 details
PGFRB_HUMANKS6B1_HUMANBioGRID16640565 details
PGFRB_HUMANERBB2_HUMANBioGRID30898150 7531698 details
PGFRB_HUMANSOCS1_HUMANHPRD10022833 details
PGFRB_HUMANP3C2B_HUMANHPRD, IntAct10805725 details
PGFRB_HUMANVATL_HUMANMINT1334459 details
PGFRB_HUMANRASA1_HUMANBioGRID, HPRD, MINT10697503 11896619 1314164 1375321 8382774 details
PGFRB_HUMANP85B_HUMANHPRD, MINT11172806 1330535 details
PGFRB_HUMANGRB10_HUMANHPRD, MINT10454568 9006901 details
PGFRB_HUMANCBL_HUMANHPRD, MINT10514377 17620338 details
PGFRB_HUMANYES_HUMANHPRD, MINT7685273 details
PGFRB_HUMANNCK1_HUMANBioGRID, HPRD, MINT10026169 1333047 7692233 9362449 details
PGFRB_HUMANSH2B2_HUMANBioGRID, MINT9989826 details
PGFRB_HUMANSLAP1_HUMANBioGRID, MINT18193084 9742401 details
PGFRB_HUMANHS90B_HUMANIntAct22939624 details
PGFRB_HUMANSTAT3_HUMANBioGRID, HPRD, IntAct25241761 9484840 details
PGFRB_HUMANSTA5A_HUMANBioGRID, HPRD, IntAct25241761 9484840 details
PGFRB_HUMANP55G_HUMANBioGRID, HPRD, IntAct11172806 25241761 details
PGFRB_HUMANCRKL_HUMANIntAct23397142 details
PGFRB_HUMANSTAT1_HUMANHPRD, IntAct23397142 8549654 9484840 details
PGFRB_HUMANLAP4B_HUMANIntAct25594178 details
PGFRB_HUMANPDGFC_HUMANDIP11297552 details
PGFRB_HUMANIL1R1_HUMANDIP16477012 details
PGFRB_HUMANVGFR2_HUMANDIP18997771 details
PGFRB_HUMANLRP6_HUMANDIP21245321 details
PGFRB_HUMANLRIG2_HUMANIntAct30015847 details
PGFRB_HUMANVAV2_HUMANBioGRID10938113 details
PGFRB_HUMANVAV3_HUMANBioGRID10938113 details
PGFRB_HUMANCOPA_HUMANBioGRID, HPRD9207175 details
PGFRB_HUMANSH3K1_HUMANBioGRID12177062 details
PGFRB_HUMANITB3_HUMANBioGRID, HPRD10964931 details
PGFRB_HUMANSHC1_HUMANBioGRID, HPRD8195171 details
PGFRB_HUMANS1PR1_HUMANBioGRID, HPRD12480944 details
PGFRB_HUMANE2AK2_HUMANBioGRID, HPRD11350938 details
PGFRB_HUMANSNX4_HUMANBioGRID, HPRD9819414 details
PGFRB_HUMANEGFR_HUMANBioGRID, HPRD7531698 9506992 details
PGFRB_HUMANPDC6I_HUMANBioGRID17082185 details
PGFRB_HUMANARBK1_HUMANBioGRID12381737 details
PGFRB_HUMANMFGM_HUMANBioGRID21868707 details
PGFRB_HUMANETV6_HUMANBioGRID22262849 details
PGFRB_HUMANIRF8_HUMANBioGRID22262849 details
PGFRB_HUMANERRFI_HUMANBioGRID19815557 details
PGFRB_HUMANCBLB_HUMANBioGRID27048651 details
PGFRB_HUMANHIP1_HUMANBioGRID23836884 details
PGFRB_HUMANCLH1_HUMANBioGRID23836884 details
PGFRB_HUMANFRS2_HUMANBioGRID19339244 details
PGFRB_HUMANRIN1_HUMANBioGRID12783862 details
PGFRB_HUMANPK3CA_HUMANHPRD8702949 details
PGFRB_HUMANCOPB_HUMANHPRD9207175 details
PGFRB_HUMANBAG1_HUMANHPRD8947043 details
PGFRB_HUMANHAP28_HUMANHPRD11331882 details
PGFRB_HUMANPTN2_HUMANHPRD14966296 15588985 details
PGFRB_HUMANPDGFD_HUMANHPRD14514732 details
PGFRB_HUMANJAK1_HUMANHPRD8657151 9484840 details
PGFRB_HUMANJAK2_HUMANHPRD8657151 9484840 details
PGFRB_HUMANTYK2_HUMANHPRD8657151 9484840 details
PGFRB_HUMANARAF_HUMANHPRD15763428 details
PGFRB_HUMANPRDX2_HUMANHPRD15902258 details
PGFRB_HUMANSTA5B_HUMANHPRD9484840 details
PGFRB_HUMANGAB1_HUMANHPRD14973141 details