Entity Details

Primary name HLAC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10321
EntryNameHLAC_HUMAN
FullNameHLA class I histocompatibility antigen, C alpha chain
TaxID9606
Evidenceevidence at protein level
Length366
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesHLA-C

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0002250 adaptive immune response
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006955 immune response
GO:0009986 cell surface
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016020 membrane
GO:0016032 viral process
GO:0030667 secretory granule membrane
GO:0030670 phagocytic vesicle membrane
GO:0031901 early endosome membrane
GO:0042605 peptide antigen binding
GO:0042612 MHC class I protein complex
GO:0043312 neutrophil degranulation
GO:0046977 TAP binding
GO:0050776 regulation of immune response
GO:0055038 recycling endosome membrane
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0070062 extracellular exosome
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane

Subcellular Location

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Subcellular Location
Cell membrane
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR001039 MHC class I alpha chain, alpha1 alpha2 domainsDomainDomain
IPR003597 Immunoglobulin C1-setDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR010579 MHC class I, alpha chain, C-terminalDomainDomain
IPR011161 MHC class I-like antigen recognition-likeDomainDomain
IPR011162 MHC classes I/II-like antigen recognition proteinFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR037055 MHC class I-like antigen recognition-like superfamilyFamilyHomologous superfamily

Diseases

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Interactions

68 interactions

InteractorPartnerSourcesPublicationsLink
HLAC_HUMANB2MG_HUMANBioGRID, HPRD, IntAct, MINT10429675 2450918 26186194 27649529 28514442 28546555 details
HLAC_HUMANMPIP1_HUMANBioGRID, IntAct21988832 details
HLAC_HUMANYBOX1_HUMANBioGRID, IntAct21988832 details
HLAC_HUMANTANK_HUMANBioGRID, IntAct21988832 details
HLAC_HUMANTMG4_HUMANBioGRID, IntAct21988832 details
HLAC_HUMANBATF2_HUMANBioGRID, IntAct21988832 details
HLAC_HUMANKI2S4_HUMANHPRD, IntAct19858347 9521070 details
HLAC_HUMANKI2L1_HUMANBioGRID, HPRD, IntAct10429675 10820396 11009104 11163076 11323700 12454284 12794140 18624290 19858347 28546555 9378975 9686591 9768753 details
HLAC_HUMANKI2L3_HUMANBioGRID, HPRD, IntAct10497191 18322206 19858347 8692965 9768753 details
HLAC_HUMANKI2L2_HUMANBioGRID, HPRD, IntAct10190900 10850706 18322206 details
HLAC_HUMANKI2S1_HUMANHPRD, IntAct18624290 28546555 7650491 9464792 details
HLAC_HUMANLIRB2_HUMANDIP17056715 details
HLAC_HUMANKI2S5_HUMANIntAct28685972 details
HLAC_HUMANGP182_HUMANBioGRID, MINT28298427 details
HLAC_HUMANGPR37_HUMANBioGRID, MINT28298427 details
HLAC_HUMANNPSR1_HUMANBioGRID, MINT28298427 details
HLAC_HUMANOPRX_HUMANBioGRID, MINT28298427 details
HLAC_HUMANNAL12_HUMANI2D32226298 details
HLAC_HUMANLIRB1_HUMANBioGRID, HPRD12853576 details
HLAC_HUMANHLAC_HUMANBioGRID12794140 details
HLAC_HUMANCD8A_HUMANBioGRID, HPRD10809759 12899833 details
HLAC_HUMANKI2S2_HUMANBioGRID, HPRD11172020 details
HLAC_HUMANJIP2_HUMANBioGRID25814554 details
HLAC_HUMANPSA6_HUMANIntAct17353931 details
HLAC_HUMANMOES_HUMANIntAct17353931 details
HLAC_HUMANTHIL_HUMANIntAct17353931 details
HLAC_HUMANSEP15_HUMANIntAct17353931 details
HLAC_HUMANRHPN2_HUMANIntAct17353931 details
HLAC_HUMANMCM3_HUMANIntAct17353931 details
HLAC_HUMANGSTM3_HUMANIntAct17353931 details
HLAC_HUMANPSME3_HUMANIntAct17353931 details
HLAC_HUMANSYSC_HUMANIntAct17353931 details
HLAC_HUMANLKHA4_HUMANIntAct17353931 details
HLAC_HUMANNUDC_HUMANIntAct17353931 details
HLAC_HUMANHLAA_HUMANBioGRID, IntAct17353931 26186194 28514442 details
HLAC_HUMANPIN1_HUMANIntAct17353931 details
HLAC_HUMANRN213_HUMANIntAct17353931 details
HLAC_HUMANANM1_HUMANIntAct17353931 details
HLAC_HUMANPSMD6_HUMANIntAct17353931 details
HLAC_HUMANUGGG1_HUMANIntAct17353931 details
HLAC_HUMANEFTU_HUMANIntAct17353931 details
HLAC_HUMANPCBP1_HUMANIntAct17353931 details
HLAC_HUMANEIF3F_HUMANIntAct17353931 details
HLAC_HUMANCBR1_HUMANIntAct17353931 details
HLAC_HUMANMARE1_HUMANIntAct17353931 details
HLAC_HUMANPCNA_HUMANIntAct17353931 details
HLAC_HUMANPSB4_HUMANIntAct17353931 details
HLAC_HUMANTIF1B_HUMANIntAct17353931 details
HLAC_HUMANPYRG1_HUMANIntAct17353931 details
HLAC_HUMANGANAB_HUMANIntAct17353931 details
HLAC_HUMANCPSF5_HUMANIntAct17353931 details
HLAC_HUMANAATM_HUMANIntAct17353931 details
HLAC_HUMANGUAA_HUMANIntAct17353931 details
HLAC_HUMANHLAB_HUMANBioGRID, IntAct17353931 26186194 28514442 details
HLAC_HUMANPSA2_HUMANIntAct17353931 details
HLAC_HUMANEIF3L_HUMANIntAct17353931 details
HLAC_HUMANCLH1_HUMANIntAct17353931 details
HLAC_HUMANCALM2_HUMANIntAct17353931 details
HLAC_HUMANIMDH2_HUMANIntAct17353931 details
HLAC_HUMANKI3S1_HUMANIntAct27649529 details
HLAC_HUMANMD2L2_HUMANBioGRID, IntAct, UniProt26186194 28514442 29656893 30022168 details
HLAC_HUMANDISC1_HUMANIntAct31413325 details
HLAC_HUMANBIP_HUMANBioGRID, HPRD7957306 details
HLAC_HUMANTAP2_HUMANBioGRID, HPRD9551969 details
HLAC_HUMANRN139_HUMANBioGRID19720873 details
HLAC_HUMANST7_HUMANBioGRID29395067 details
HLAC_HUMANCALR_HUMANHPRD8769474 details
HLAC_HUMANTPSN_HUMANHPRD8769474 details