Entity Details

Primary name KIT_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10721
EntryNameKIT_HUMAN
FullNameMast/stem cell growth factor receptor Kit
TaxID9606
Evidenceevidence at protein level
Length976
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesKIT

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000187 obsolete activation of MAPK activity
GO:0001541 ovarian follicle development
GO:0001650 fibrillar center
GO:0001669 acrosomal vesicle
GO:0002020 protease binding
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002318 myeloid progenitor cell differentiation
GO:0002320 lymphoid progenitor cell differentiation
GO:0002327 immature B cell differentiation
GO:0002551 mast cell chemotaxis
GO:0002732 positive regulation of dendritic cell cytokine production
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005020 stem cell factor receptor activity
GO:0005524 ATP binding
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006687 glycosphingolipid metabolic process
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007283 spermatogenesis
GO:0007286 spermatid development
GO:0008284 positive regulation of cell population proliferation
GO:0008354 germ cell migration
GO:0008360 regulation of cell shape
GO:0008542 visual learning
GO:0008584 male gonad development
GO:0009897 external side of plasma membrane
GO:0009898 cytoplasmic side of plasma membrane
GO:0010863 positive regulation of phospholipase C activity
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0019827 stem cell population maintenance
GO:0019955 cytokine binding
GO:0030032 lamellipodium assembly
GO:0030097 hemopoiesis
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
GO:0030218 erythrocyte differentiation
GO:0030318 melanocyte differentiation
GO:0030335 positive regulation of cell migration
GO:0031274 positive regulation of pseudopodium assembly
GO:0031532 actin cytoskeleton reorganization
GO:0032765 positive regulation of mast cell cytokine production
GO:0033674 positive regulation of kinase activity
GO:0035019 somatic stem cell population maintenance
GO:0035162 embryonic hemopoiesis
GO:0035234 ectopic germ cell programmed cell death
GO:0035701 hematopoietic stem cell migration
GO:0035855 megakaryocyte development
GO:0038093 Fc receptor signaling pathway
GO:0038109 Kit signaling pathway
GO:0038162 erythropoietin-mediated signaling pathway
GO:0042127 regulation of cell population proliferation
GO:0042169 SH2 domain binding
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042803 protein homodimerization activity
GO:0043069 negative regulation of programmed cell death
GO:0043235 receptor complex
GO:0043303 mast cell degranulation
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043473 pigmentation
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0043586 tongue development
GO:0045747 positive regulation of Notch signaling pathway
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
GO:0046686 response to cadmium ion
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0048103 somatic stem cell division
GO:0048170 positive regulation of long-term neuronal synaptic plasticity
GO:0048565 digestive tract development
GO:0048863 stem cell differentiation
GO:0050673 epithelial cell proliferation
GO:0050910 detection of mechanical stimulus involved in sensory perception of sound
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051897 positive regulation of protein kinase B signaling
GO:0060326 cell chemotaxis
GO:0060374 mast cell differentiation
GO:0070662 mast cell proliferation
GO:0097067 cellular response to thyroid hormone stimulus
GO:0097324 melanocyte migration
GO:0097326 melanocyte adhesion
GO:0120072 positive regulation of pyloric antrum smooth muscle contraction
GO:1904251 regulation of bile acid metabolic process
GO:1904343 positive regulation of colon smooth muscle contraction
GO:1904349 positive regulation of small intestine smooth muscle contraction
GO:1905065 positive regulation of vascular associated smooth muscle cell differentiation

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001824 Tyrosine-protein kinase, receptor class III, conserved siteSiteConserved site
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013151 ImmunoglobulinDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR027263 Mast/stem cell growth factor receptorFamilyFamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00398 SorafenibDrugbanksmall molecule
DB00619 ImatinibDrugbanksmall molecule
DB01254 DasatinibDrugbanksmall molecule
DB01268 SunitinibDrugbanksmall molecule
DB01962 PhosphonotyrosineDrugbanksmall molecule
DB04868 NilotinibDrugbanksmall molecule
DB05146 XL820Drugbanksmall molecule
DB05913 OSI-930Drugbanksmall molecule
DB06080 ABT-869Drugbanksmall molecule
DB06589 PazopanibDrugbanksmall molecule
DB06595 MidostaurinDrugbanksmall molecule
DB08896 RegorafenibDrugbanksmall molecule
DB08901 PonatinibDrugbanksmall molecule
DB09078 LenvatinibDrugbanksmall molecule
DB09103 AncestimDrugbankbiotech
DB12010 FostamatinibDrugbanksmall molecule
DB12147 ErdafitinibDrugbanksmall molecule
DB12742 AmuvatinibDrugbanksmall molecule
DB12978 PexidartinibDrugbanksmall molecule
DB14840 RipretinibDrugbanksmall molecule
DB15233 AvapritinibDrugbanksmall molecule

Interactions

104 interactions

InteractorPartnerSourcesPublicationsLink
KIT_HUMANSCF_HUMANBioGRID, HPRD, IntAct1375232 1379243 17662946 7680037 details
KIT_HUMANPTPRJ_HUMANIntAct19167335 details
KIT_HUMANGRB2_HUMANBioGRID, HPRD, IntAct, MINT10022833 10377264 12444928 17452978 17904548 24728074 7523381 7523859 8647802 8950973 details
KIT_HUMANCRK_HUMANBioGRID, HPRD, IntAct, MINT12878163 24728074 9092574 9233773 details
KIT_HUMANP85A_HUMANBioGRID, HPRD, IntAct, MINT10022833 11071635 12878163 1382595 17452978 24728074 25241761 7509796 7537096 9233773 details
KIT_HUMANGRB7_HUMANBioGRID, HPRD, IntAct, MINT10377264 12444928 24728074 details
KIT_HUMANPLCG1_HUMANBioGRID, HPRD, IntAct, MINT11071635 14647465 24728074 25241761 7536744 7537096 details
KIT_HUMANP85B_HUMANBioGRID, HPRD, IntAct, MINT10022833 24728074 7537096 details
KIT_HUMANPTN6_HUMANBioGRID, HPRD, MINT12614164 7684496 9528781 details
KIT_HUMANSTAT1_HUMANBioGRID, HPRD, IntAct25241761 9355737 details
KIT_HUMANPTN11_HUMANBioGRID, HPRD, IntAct12444928 24728074 7523381 9528781 details
KIT_HUMANPLCG2_HUMANBioGRID, IntAct24728074 details
KIT_HUMANP55G_HUMANBioGRID, IntAct24728074 details
KIT_HUMANSOCS6_HUMANBioGRID, HPRD, IntAct14707129 21030588 24728074 details
KIT_HUMANSH21B_HUMANBioGRID, IntAct24728074 details
KIT_HUMAN3BP2_HUMANBioGRID, IntAct24728074 details
KIT_HUMANSH22A_HUMANBioGRID, IntAct24728074 details
KIT_HUMANSH2B3_HUMANBioGRID, HPRD, IntAct11805142 18588518 24728074 details
KIT_HUMANLCK_HUMANBioGRID, HPRD, IntAct24728074 9788619 details
KIT_HUMANSH2D3_HUMANBioGRID, IntAct24728074 details
KIT_HUMANSRC_HUMANBioGRID, HPRD, IntAct12444928 12878163 24728074 details
KIT_HUMANRASA1_HUMANBioGRID, HPRD, IntAct11071635 24728074 details
KIT_HUMANZAP70_HUMANBioGRID, IntAct24728074 details
KIT_HUMANYES_HUMANBioGRID, HPRD, IntAct11071635 24728074 details
KIT_HUMANFGR_HUMANBioGRID, IntAct24728074 details
KIT_HUMANTNS2_HUMANBioGRID, IntAct24728074 details
KIT_HUMANSHC1_HUMANBioGRID, IntAct24728074 details
KIT_HUMANSHC2_HUMANBioGRID, IntAct24728074 details
KIT_HUMANHSH2D_HUMANBioGRID, IntAct24728074 details
KIT_HUMANHCK_HUMANBioGRID, HPRD, IntAct11071635 24728074 details
KIT_HUMANABL2_HUMANBioGRID, IntAct24728074 details
KIT_HUMANSOCS2_HUMANBioGRID, IntAct24728074 details
KIT_HUMANTENS3_HUMANBioGRID, IntAct24728074 details
KIT_HUMANSTAP1_HUMANBioGRID, HPRD, IntAct10679268 24728074 details
KIT_HUMANSH21A_HUMANBioGRID, IntAct24728074 details
KIT_HUMANLYN_HUMANBioGRID, HPRD, IntAct11825908 24728074 9341198 details
KIT_HUMANNCK1_HUMANBioGRID, IntAct24728074 details
KIT_HUMANBLNK_HUMANBioGRID, IntAct24728074 details
KIT_HUMANNCK2_HUMANBioGRID, IntAct24728074 details
KIT_HUMANBCAR3_HUMANBioGRID, IntAct24728074 details
KIT_HUMANSHC3_HUMANBioGRID, IntAct24728074 details
KIT_HUMANTXK_HUMANBioGRID, IntAct24728074 details
KIT_HUMANSHC4_HUMANBioGRID, IntAct24728074 details
KIT_HUMANBLK_HUMANBioGRID, IntAct24728074 details
KIT_HUMANPTK6_HUMANBioGRID, IntAct24728074 details
KIT_HUMANFES_HUMANBioGRID, IntAct24728074 details
KIT_HUMANABL1_HUMANBioGRID, HPRD, IntAct12374739 24728074 details
KIT_HUMANSOCS3_HUMANBioGRID, IntAct24728074 details
KIT_HUMANSLAP2_HUMANBioGRID, IntAct24728074 details
KIT_HUMANGRAP2_HUMANBioGRID, HPRD, IntAct24728074 9872323 details
KIT_HUMANSHB_HUMANBioGRID, IntAct24728074 details
KIT_HUMANKSYK_HUMANBioGRID, IntAct24728074 details
KIT_HUMANSOCS5_HUMANBioGRID, HPRD, IntAct14707129 24728074 details
KIT_HUMANTENS1_HUMANBioGRID, IntAct24728074 details
KIT_HUMANVAV3_HUMANBioGRID, IntAct24728074 details
KIT_HUMANTEC_HUMANBioGRID, HPRD, IntAct11071635 24728074 7526158 details
KIT_HUMANSTYX_HUMANBioGRID, MINT28065597 details
KIT_HUMANILKAP_HUMANBioGRID, MINT28065597 details
KIT_HUMANSOCS1_HUMANBioGRID, HPRD10022833 29991678 details
KIT_HUMANCRKL_HUMANBioGRID, HPRD11071635 9092574 details
KIT_HUMANSHIP1_HUMANBioGRID, HPRD11071635 details
KIT_HUMANDOK1_HUMANBioGRID, HPRD11825908 details
KIT_HUMANGRB10_HUMANBioGRID, HPRD11809791 details
KIT_HUMANMATK_HUMANBioGRID, HPRD7536744 9038210 details
KIT_HUMANMPDZ_HUMANBioGRID, HPRD11018522 details
KIT_HUMANGRAP_HUMANBioGRID, HPRD8647802 details
KIT_HUMANIL7RA_HUMANBioGRID17554063 details
KIT_HUMANJAK3_HUMANBioGRID17554063 details
KIT_HUMANSTA5B_HUMANBioGRID, HPRD10358045 17554063 details
KIT_HUMANPTN20_HUMANBioGRID28065597 details
KIT_HUMANKIT_HUMANBioGRID, HPRD10377264 1379243 9799234 9949175 details
KIT_HUMANCSF1R_HUMANBioGRID9949175 details
KIT_HUMANBMPR2_HUMANBioGRID16155937 details
KIT_HUMANPTPRU_HUMANHPRD, MINT10397721 details
KIT_HUMANPTN12_HUMANMINT12614164 details
KIT_HUMANPK3CG_HUMANBioGRID, HPRD, IntAct25241761 7520444 details
KIT_HUMANBCR_HUMANBioGRID, IntAct25241761 8757502 details
KIT_HUMANCSF2R_HUMANBioGRID, HPRD, IntAct16760463 25241761 details
KIT_HUMANCD9_HUMANBioGRID, HPRD12036870 details
KIT_HUMANCD63_HUMANBioGRID12036870 details
KIT_HUMANCD81_HUMANBioGRID, HPRD12036870 details
KIT_HUMANCLH1_HUMANBioGRID, HPRD10477727 details
KIT_HUMANJAK2_HUMANBioGRID, HPRD7527392 8611693 9355737 details
KIT_HUMANPTPRO_HUMANBioGRID, HPRD10397721 details
KIT_HUMANSH3K1_HUMANBioGRID12177062 details
KIT_HUMANCBLB_HUMANBioGRID, HPRD12177062 15315962 details
KIT_HUMANCBL_HUMANBioGRID, HPRD15315962 25737303 8950973 details
KIT_HUMANPGFRA_HUMANBioGRID17452978 details
KIT_HUMANENPL_HUMANBioGRID25737303 details
KIT_HUMANPK3CA_HUMANBioGRID7691885 details
KIT_HUMANPLCE1_HUMANBioGRID, HPRD12878163 details
KIT_HUMANACTS_HUMANBioGRID12878163 details
KIT_HUMANFYN_HUMANBioGRID, HPRD12374739 14647465 9799234 details
KIT_HUMANKHDR1_HUMANBioGRID14647465 details
KIT_HUMANKPCA_HUMANHPRD7539802 details
KIT_HUMANSPRE1_HUMANHPRD12646235 details
KIT_HUMANSH2B2_HUMANHPRD10872802 details
KIT_HUMANSPRE2_HUMANHPRD12646235 14981116 details
KIT_HUMANIL3RB_HUMANHPRD15308671 details
KIT_HUMANKPCB_HUMANHPRD7693453 details
KIT_HUMANBTK_HUMANHPRD15007095 details
KIT_HUMANSTA5A_HUMANHPRD10358045 details
KIT_HUMANCISH_HUMANHPRD14707129 details
KIT_HUMANEPOR_HUMANHPRD11124255 details