Entity Details

Primary name UMPS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP11172
EntryNameUMPS_HUMAN
FullNameUridine 5'-monophosphate synthase
TaxID9606
Evidenceevidence at protein level
Length480
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesUMPS

GO terms

Show/Hide Table
GOName
GO:0004588 orotate phosphoribosyltransferase activity
GO:0004590 orotidine-5'-phosphate decarboxylase activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006222 UMP biosynthetic process
GO:0007565 female pregnancy
GO:0007595 lactation
GO:0019856 pyrimidine nucleobase biosynthetic process
GO:0035690 cellular response to drug
GO:0042802 identical protein binding
GO:0044205 'de novo' UMP biosynthetic process
GO:0046134 pyrimidine nucleoside biosynthetic process

Subcellular Location

Show/Hide Table

Domains

Show/Hide Table
DomainNameCategoryType
IPR000836 Phosphoribosyltransferase domainDomainDomain
IPR001754 Orotidine 5'-phosphate decarboxylase domainDomainDomain
IPR004467 Orotate phosphoribosyl transferase domainDomainDomain
IPR011060 Ribulose-phosphate binding barrelFamilyHomologous superfamily
IPR013785 Aldolase-type TIM barrelFamilyHomologous superfamily
IPR014732 Orotidine 5'-phosphate decarboxylaseFamilyFamily
IPR018089 Orotidine 5'-phosphate decarboxylase, active siteSiteActive site
IPR023031 Orotate phosphoribosyltransferaseFamilyFamily
IPR029057 Phosphoribosyltransferase-likeFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00544 FluorouracilDrugbanksmall molecule
DB02890 6-hydroxyuridine-5'-phosphateDrugbanksmall molecule