Entity Details

Primary name ODPB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP11177
EntryNameODPB_HUMAN
FullNamePyruvate dehydrogenase E1 component subunit beta, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length359
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesPDHB

GO terms

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GOName
GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005967 mitochondrial pyruvate dehydrogenase complex
GO:0006006 glucose metabolic process
GO:0006086 acetyl-CoA biosynthetic process from pyruvate
GO:0006090 pyruvate metabolic process
GO:0006099 tricarboxylic acid cycle
GO:0045254 pyruvate dehydrogenase complex
GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate

Subcellular Location

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Subcellular Location
Mitochondrion matrix

Domains

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DomainNameCategoryType
IPR005475 Transketolase-like, pyrimidine-binding domainDomainDomain
IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain IIFamilyHomologous superfamily
IPR027110 Pyruvate dehydrogenase E1 component subunit betaFamilyFamily
IPR029061 Thiamin diphosphate-binding foldFamilyHomologous superfamily
IPR033248 Transketolase, C-terminal domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00119 Pyruvic acidDrugbanksmall molecule
DB00157 NADHDrugbanksmall molecule

Interactions

28 interactions

InteractorPartnerSourcesPublicationsLink
ODPB_HUMANODPA_HUMANBioGRID, DIP, HPRD, IntAct12651851 19081061 22939629 26186194 26344197 28514442 29128334 31536960 34079125 7864652 details
ODPB_HUMANODP2_HUMANBioGRID, IntAct, MINT14638692 18206651 26186194 26344197 28514442 details
ODPB_HUMANFCERA_HUMANBioGRID, IntAct21988832 details
ODPB_HUMANGBB2_HUMANBioGRID, IntAct21988832 details
ODPB_HUMANITB1_HUMANBioGRID, IntAct21988832 details
ODPB_HUMANANXA7_HUMANBioGRID, MINT21900206 details
ODPB_HUMANCDN1A_HUMANBioGRID, MINT21900206 details
ODPB_HUMANGRB7_HUMANBioGRID, MINT21900206 details
ODPB_HUMANPFD1_HUMANBioGRID, MINT21900206 details
ODPB_HUMANRAP1B_HUMANBioGRID, MINT21900206 details
ODPB_HUMANRCC1_HUMANBioGRID, MINT21900206 details
ODPB_HUMANT22D1_HUMANBioGRID, MINT21900206 details
ODPB_HUMANAKT1_HUMANBioGRID, MINT25640309 details
ODPB_HUMANAA2AR_HUMANBioGRID, MINT28298427 details
ODPB_HUMANTRI63_HUMANBioGRID, HPRD15967462 18468620 details
ODPB_HUMANHCD2_HUMANBioGRID22496890 details
ODPB_HUMANBRF2_HUMANIntAct17353931 details
ODPB_HUMANWRP73_HUMANIntAct17353931 details
ODPB_HUMANCRCM_HUMANIntAct17353931 details
ODPB_HUMANSOMA_HUMANIntAct17353931 details
ODPB_HUMANIKKE_HUMANIntAct17353931 details
ODPB_HUMANCFA20_HUMANBioGRID, IntAct27173435 unassigned1312 details
ODPB_HUMANODPX_HUMANBioGRID, HPRD, IntAct22939629 26186194 28514442 7864652 details
ODPB_HUMANSHAN3_HUMANMINT21653829 details
ODPB_HUMANODPAT_HUMANBioGRID, HPRD26344197 7864652 details
ODPB_HUMANSRRM2_HUMANBioGRID16159877 details
ODPB_HUMANAKTIP_HUMANBioGRID27512140 details
ODPB_HUMANODPB_HUMANHPRD12651851 2377599 details