Entity Details

Primary name XRCC5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP13010
EntryNameXRCC5_HUMAN
FullNameX-ray repair cross-complementing protein 5
TaxID9606
Evidenceevidence at protein level
Length732
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesXRCC5

GO terms

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GOName
GO:0000723 telomere maintenance
GO:0000781 chromosome, telomeric region
GO:0000783 nuclear telomere cap complex
GO:0000976 transcription cis-regulatory region binding
GO:0002218 activation of innate immune response
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003684 damaged DNA binding
GO:0003690 double-stranded DNA binding
GO:0003723 RNA binding
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006310 DNA recombination
GO:0006974 cellular response to DNA damage stimulus
GO:0007420 brain development
GO:0008022 protein C-terminus binding
GO:0008047 enzyme activator activity
GO:0008094 ATPase, acting on DNA
GO:0008283 cell population proliferation
GO:0016020 membrane
GO:0031625 ubiquitin protein ligase binding
GO:0032040 small-subunit processome
GO:0032204 regulation of telomere maintenance
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0032481 positive regulation of type I interferon production
GO:0032991 protein-containing complex
GO:0032993 protein-DNA complex
GO:0034462 small-subunit processome assembly
GO:0034511 U3 snoRNA binding
GO:0034774 secretory granule lumen
GO:0042162 telomeric DNA binding
GO:0042493 response to drug
GO:0043085 positive regulation of catalytic activity
GO:0043312 neutrophil degranulation
GO:0043564 Ku70:Ku80 complex
GO:0044877 protein-containing complex binding
GO:0045027 DNA end binding
GO:0045087 innate immune response
GO:0045860 positive regulation of protein kinase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048660 regulation of smooth muscle cell proliferation
GO:0050769 positive regulation of neurogenesis
GO:0051973 positive regulation of telomerase activity
GO:0060218 hematopoietic stem cell differentiation
GO:0070198 protein localization to chromosome, telomeric region
GO:0070419 nonhomologous end joining complex
GO:0071398 cellular response to fatty acid
GO:0071475 cellular hyperosmotic salinity response
GO:0071480 cellular response to gamma radiation
GO:0071481 cellular response to X-ray
GO:0075713 establishment of integrated proviral latency
GO:0090734 site of DNA damage
GO:1904430 negative regulation of t-circle formation
GO:1990830 cellular response to leukemia inhibitory factor
GO:1990904 ribonucleoprotein complex

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR002035 von Willebrand factor, type ADomainDomain
IPR005160 Ku70/Ku80 C-terminal armDomainDomain
IPR005161 Ku70/Ku80, N-terminal alpha/betaDomainDomain
IPR006164 Ku70/Ku80 beta-barrel domainDomainDomain
IPR014893 Ku, C-terminalDomainDomain
IPR016194 SPOC-like, C-terminal domain superfamilyFamilyHomologous superfamily
IPR024193 Ku80FamilyFamily
IPR036465 von Willebrand factor A-like domain superfamilyFamilyHomologous superfamily
IPR036494 Ku, C-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

155 interactions

InteractorPartnerSourcesPublicationsLink
XRCC5_HUMANWRN_HUMANBioGRID, HPRD, IntAct, MINT, Molecular Connections10783163 10880505 11328876 12177300 12937274 14734561 21679440 26496610 details
XRCC5_HUMANXRCC6_HUMANBioGRID, DIP, HPRD, IntAct, MINT, Molecular Connections10207052 10219089 10446239 10750018 10757784 10783163 10984620 11196700 11493912 12145306 12519782 15023334 15367688 15520013 15910003 17159921 17283121 17308091 18809223 19118032 19177010 19906305 21070772 21172662 21454661 21679440 22451927 22863883 22939629 24981860 25574025 26344197 26446488 26496610 26774286 28035050 28514442 30021884 30585729 32296183 33005030 7699019 8702520 9488450 details
XRCC5_HUMANPARP1_HUMANBioGRID, HPRD, IntAct, Molecular Connections10400681 14734561 16490787 16794079 17283121 20085707 21575865 21679440 24140708 34079125 details
XRCC5_HUMANHXB7_HUMANBioGRID, IntAct17308091 details
XRCC5_HUMANPRKDC_HUMANBioGRID, DIP, HPRD, I2D, IntAct10207052 10446239 10750018 12393188 15520013 15758953 16857680 17308091 19303849 20023628 20085707 20711232 21679440 22404984 26344197 26446488 26496610 28154079 28345663 33005030 9312071 details
XRCC5_HUMANCEBPA_HUMANBioGRID, IntAct16490787 details
XRCC5_HUMANAPLF_HUMANBioGRID, DIP, IntAct, MINT17396150 20098424 23178593 26186194 28514442 details
XRCC5_HUMANCOIL_HUMANBioGRID, MINT21070772 details
XRCC5_HUMANCSK21_HUMANBioGRID, I2D20711232 details
XRCC5_HUMANCDC16_HUMANBioGRID, IntAct21988832 details
XRCC5_HUMANTOP1_HUMANBioGRID, Molecular Connections21679440 28415827 details
XRCC5_HUMANHSPB1_HUMANBioGRID, IntAct25277244 details
XRCC5_HUMANNR1H4_HUMANBioGRID, UniProt19833092 details
XRCC5_HUMANDUX4_HUMANBioGRID, IntAct26816005 details
XRCC5_HUMANZRAN1_HUMANBioGRID, IntAct32296183 details
XRCC5_HUMANPRGR_HUMANBioGRID, IntAct10750018 unassigned2875 details
XRCC5_HUMANANDR_HUMANBioGRID, HPRD15640154 details
XRCC5_HUMANTERT_HUMANBioGRID, HPRD12377759 21855630 details
XRCC5_HUMANAPEX1_HUMANBioGRID8621488 details
XRCC5_HUMANTNR5_HUMANBioGRID, HPRD10514012 details
XRCC5_HUMANHSF1_HUMANBioGRID, HPRD9325337 details
XRCC5_HUMANBRCA1_HUMANBioGRID18936166 23344954 26831064 details
XRCC5_HUMANPDX1_HUMANBioGRID16166097 details
XRCC5_HUMANCAF1A_HUMANBioGRID21209461 details
XRCC5_HUMANBAZ1A_HUMANBioGRID21172662 details
XRCC5_HUMANRPB1_HUMANBioGRID, HPRD12391174 details
XRCC5_HUMANDNLI3_HUMANBioGRID12897160 details
XRCC5_HUMANATM_HUMANBioGRID, HPRD15758953 17171639 details
XRCC5_HUMANATR_HUMANBioGRID, HPRD15758953 details
XRCC5_HUMANMDC1_HUMANBioGRID15377652 details
XRCC5_HUMANXRCC5_HUMANBioGRID, HPRD10750018 12519782 details
XRCC5_HUMANGRAA_HUMANBioGRID16440001 details
XRCC5_HUMANGRAB_HUMANBioGRID8760815 details
XRCC5_HUMANELF3_HUMANBioGRID15075319 details
XRCC5_HUMANEHF_HUMANBioGRID15075319 details
XRCC5_HUMANUBC9_HUMANBioGRID15561718 details
XRCC5_HUMANSUMO2_HUMANBioGRID19394292 32786267 details
XRCC5_HUMANSRPK2_HUMANBioGRID26167880 details
XRCC5_HUMANAP2A_HUMANBioGRID19906305 details
XRCC5_HUMANRN126_HUMANBioGRID27895153 details
XRCC5_HUMANUBC_HUMANBioGRID26774286 details
XRCC5_HUMANZBT7A_HUMANBioGRID26446488 details
XRCC5_HUMANUCHL3_HUMANBioGRID30559450 details
XRCC5_HUMANERPG3_HUMANBioGRID26030138 31722399 details
XRCC5_HUMANERCC6_HUMANBioGRID26030138 31722399 details
XRCC5_HUMANPTEN_HUMANBioGRID31685992 details
XRCC5_HUMANNFKB2_HUMANIntAct14743216 details
XRCC5_HUMANTE2IP_HUMANBioGRID, HPRD, IntAct15100233 15383534 details
XRCC5_HUMANNHEJ1_HUMANBioGRID, MINT, UniProt18064046 21349273 26774286 31548606 details
XRCC5_HUMANH2AX_HUMANBioGRID, IntAct18406329 20085707 21679440 details
XRCC5_HUMANTOP2A_HUMANBioGRID, IntAct12393188 20085707 details
XRCC5_HUMANTFCP2_HUMANIntAct20195357 details
XRCC5_HUMANPIAS4_HUMANMINT19779455 details
XRCC5_HUMANGOLP3_HUMANIntAct24485452 details
XRCC5_HUMANNAA15_HUMANBioGRID, HPRD, IntAct12145306 12145312 26496610 details
XRCC5_HUMANPPM1G_HUMANBioGRID, IntAct28330616 details
XRCC5_HUMANCHD1L_HUMANBioGRID, DIP19661379 19666485 details
XRCC5_HUMANH31_HUMANBioGRID, DIP, IntAct20080577 20504901 26527279 29568061 34079125 details
XRCC5_HUMANRNF8_HUMANBioGRID, DIP22266820 details
XRCC5_HUMANTCTP_HUMANDIP22451927 details
XRCC5_HUMANPAXX_HUMANDIP, UniProt25574025 31548606 details
XRCC5_HUMANDTBP1_HUMANUniProt19142223 details
XRCC5_HUMANDNLI4_HUMANBioGRID, UniProt10757784 15520013 26774286 31548606 details
XRCC5_HUMANSOX2_HUMANBioGRID, MINT21280222 23667531 details
XRCC5_HUMANTERF2_HUMANBioGRID15100233 20811636 details
XRCC5_HUMANCHK1_HUMANBioGRID12756247 details
XRCC5_HUMANRBM14_HUMANBioGRID, HPRD11443112 details
XRCC5_HUMANNCOA6_HUMANBioGRID, HPRD10823961 12519782 details
XRCC5_HUMANKAT2A_HUMANBioGRID9488450 details
XRCC5_HUMANVAV_HUMANBioGRID, HPRD10673353 details
XRCC5_HUMANTYK2_HUMANBioGRID, HPRD10673353 details
XRCC5_HUMANPO2F1_HUMANBioGRID11279128 12393188 12672812 27465491 details
XRCC5_HUMANDPOLA_HUMANBioGRID, HPRD12393188 details
XRCC5_HUMANPCNA_HUMANBioGRID, HPRD11239001 12171929 12393188 details
XRCC5_HUMANPRI1_HUMANBioGRID12393188 details
XRCC5_HUMANRPAB1_HUMANBioGRID12393188 details
XRCC5_HUMANRPB4_HUMANBioGRID12393188 details
XRCC5_HUMANORC2_HUMANBioGRID, HPRD12393188 15910003 details
XRCC5_HUMANORC1_HUMANBioGRID12393188 31160578 details
XRCC5_HUMANRFC1_HUMANBioGRID12393188 26344197 details
XRCC5_HUMANBIN1_HUMANBioGRID17671430 details
XRCC5_HUMANVIGLN_HUMANBioGRID15723802 details
XRCC5_HUMANDHX9_HUMANBioGRID14704337 15723802 21679440 details
XRCC5_HUMANH2AY_HUMANBioGRID17158748 details
XRCC5_HUMANSIR6_HUMANBioGRID20157594 details
XRCC5_HUMANBARD1_HUMANBioGRID18936166 22990118 details
XRCC5_HUMANESR1_HUMANBioGRID16794079 details
XRCC5_HUMANMSX2_HUMANBioGRID, HPRD12145306 12145310 details
XRCC5_HUMANRUNX2_HUMANBioGRID, HPRD12145306 12145311 details
XRCC5_HUMANPHF1_HUMANBioGRID18385154 details
XRCC5_HUMANXRCC4_HUMANBioGRID15520013 26774286 details
XRCC5_HUMANILF2_HUMANBioGRID17389650 details
XRCC5_HUMANTHA_HUMANBioGRID17242407 details
XRCC5_HUMANTHB_HUMANBioGRID17242407 details
XRCC5_HUMANBMI1_HUMANBioGRID20668194 24457600 details
XRCC5_HUMANH33_HUMANBioGRID20504901 details
XRCC5_HUMANTERF1_HUMANBioGRID20811636 details
XRCC5_HUMANSMCA5_HUMANBioGRID21172662 details
XRCC5_HUMANCHRC1_HUMANBioGRID21172662 details
XRCC5_HUMANDPOE3_HUMANBioGRID21172662 details
XRCC5_HUMANHDAC5_HUMANBioGRID21081666 details
XRCC5_HUMANRBM39_HUMANBioGRID16051665 28302793 details
XRCC5_HUMANTYY1_HUMANBioGRID15367688 details
XRCC5_HUMANRN146_HUMANBioGRID21825151 details
XRCC5_HUMANSMRCD_HUMANBioGRID21549307 details
XRCC5_HUMANNBN_HUMANBioGRID, HPRD15758953 details
XRCC5_HUMANORC3_HUMANBioGRID15910003 details
XRCC5_HUMANORC6_HUMANBioGRID15910003 details
XRCC5_HUMANORC4_HUMANBioGRID15910003 details
XRCC5_HUMANMSH6_HUMANBioGRID21075794 details
XRCC5_HUMANHXC4_HUMANBioGRID12672812 details
XRCC5_HUMANRD23A_HUMANBioGRID19013454 details
XRCC5_HUMANHNRPC_HUMANBioGRID14704337 details
XRCC5_HUMANSSRP1_HUMANBioGRID21679440 details
XRCC5_HUMANBAX_HUMANBioGRID19177010 details
XRCC5_HUMANKCND3_HUMANBioGRID17725712 details
XRCC5_HUMANPNKP_HUMANBioGRID15385968 details
XRCC5_HUMANITA4_HUMANBioGRID22623428 details
XRCC5_HUMANDCR1C_HUMANBioGRID16857680 31900314 details
XRCC5_HUMANPPARG_HUMANBioGRID18809223 details
XRCC5_HUMANCUL7_HUMANBioGRID24711643 details
XRCC5_HUMANOBSL1_HUMANBioGRID24711643 details
XRCC5_HUMANCCDC8_HUMANBioGRID24711643 details
XRCC5_HUMANRING2_HUMANBioGRID24457600 29985131 details
XRCC5_HUMANPHRF1_HUMANBioGRID25855964 details
XRCC5_HUMANMACD1_HUMANBioGRID25735744 details
XRCC5_HUMANSENP3_HUMANBioGRID26511642 details
XRCC5_HUMANAHSA1_HUMANBioGRID22504172 details
XRCC5_HUMANUBP11_HUMANBioGRID28040451 details
XRCC5_HUMANDERL1_HUMANBioGRID28137758 details
XRCC5_HUMANSPTA1_HUMANBioGRID16889989 details
XRCC5_HUMANEP300_HUMANBioGRID29049411 30110629 details
XRCC5_HUMANUBE2S_HUMANBioGRID27593939 details
XRCC5_HUMANDDB2_HUMANBioGRID28035050 details
XRCC5_HUMANDDB1_HUMANBioGRID28035050 details
XRCC5_HUMANHIF1A_HUMANBioGRID15272235 details
XRCC5_HUMANNKX21_HUMANBioGRID28192407 details
XRCC5_HUMANKDM2B_HUMANBioGRID29985131 details
XRCC5_HUMANPCGF1_HUMANBioGRID29985131 details
XRCC5_HUMANNR4A1_HUMANBioGRID28431397 details
XRCC5_HUMANVRK1_HUMANBioGRID28927264 details
XRCC5_HUMANVRK3_HUMANBioGRID28927264 details
XRCC5_HUMANWWP2_HUMANBioGRID31048545 details
XRCC5_HUMANLRC31_HUMANBioGRID33005030 details
XRCC5_HUMANDTX2_HUMANBioGRID32937373 details
XRCC5_HUMANUBE2T_HUMANBioGRID32491994 details
XRCC5_HUMANNEMO_HUMANBioGRID31932854 details
XRCC5_HUMANSPT5H_HUMANHPRD12391174 details
XRCC5_HUMANDPOD1_HUMANHPRD12393188 details
XRCC5_HUMANSPT4H_HUMANHPRD12391174 details
XRCC5_HUMANDPOE1_HUMANHPRD12393188 details
XRCC5_HUMANTOP2B_HUMANHPRD12393188 details
XRCC5_HUMANITF2_HUMANHPRD17283121 details
XRCC5_HUMANSGO1_HUMANHPRD16541024 details
XRCC5_HUMANNDRG1_HUMANHPRD17220478 details