Entity Details

Primary name MTDC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP13995
EntryNameMTDC_HUMAN
FullNameBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length350
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesMTHFD2

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0004477 methenyltetrahydrofolate cyclohydrolase activity
GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity
GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005615 extracellular space
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0035999 tetrahydrofolate interconversion
GO:0042301 phosphate ion binding
GO:0046653 tetrahydrofolate metabolic process
GO:0046655 folic acid metabolic process

Subcellular Location

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Subcellular Location
Mitochondrion

Domains

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DomainNameCategoryType
IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolaseFamilyFamily
IPR020630 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domainDomainDomain
IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domainDomainDomain
IPR020867 Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved siteSiteConserved site
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00116 Tetrahydrofolic acidDrugbanksmall molecule
DB00157 NADHDrugbanksmall molecule