Entity Details

Primary name INSRR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP14616
EntryNameINSRR_HUMAN
FullNameInsulin receptor-related protein
TaxID9606
Evidenceevidence at protein level
Length1297
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesINSRR

GO terms

Show/Hide Table
GOName
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005009 insulin-activated receptor activity
GO:0005524 ATP binding
GO:0005887 integral component of plasma membrane
GO:0005899 insulin receptor complex
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0030238 male sex determination
GO:0030424 axon
GO:0031532 actin cytoskeleton reorganization
GO:0033674 positive regulation of kinase activity
GO:0043235 receptor complex
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043560 insulin receptor substrate binding
GO:0046777 protein autophosphorylation
GO:0071469 cellular response to alkaline pH

Subcellular Location

Show/Hide Table
Subcellular Location
Membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000494 Receptor L-domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR002011 Tyrosine-protein kinase, receptor class II, conserved siteSiteConserved site
IPR003961 Fibronectin type IIIDomainDomain
IPR006211 Furin-like cysteine-rich domainDomainDomain
IPR006212 Furin-like repeatRepeatRepeat
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016246 Tyrosine-protein kinase, insulin-like receptorFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR028792 Insulin receptor-related proteinFamilyFamily
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR036941 Receptor L-domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule