Entity Details

Primary name KPYM_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP14618
EntryNameKPYM_HUMAN
FullNamePyruvate kinase PKM
TaxID9606
Evidenceevidence at protein level
Length531
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesPKM

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0001666 response to hypoxia
GO:0001889 liver development
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0004743 pyruvate kinase activity
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005791 rough endoplasmic reticulum
GO:0005829 cytosol
GO:0005929 cilium
GO:0006096 glycolytic process
GO:0006754 ATP biosynthetic process
GO:0007584 response to nutrient
GO:0009629 response to gravity
GO:0012501 programmed cell death
GO:0014870 response to muscle inactivity
GO:0016301 kinase activity
GO:0023026 MHC class II protein complex binding
GO:0030955 potassium ion binding
GO:0031100 animal organ regeneration
GO:0031982 vesicle
GO:0032869 cellular response to insulin stimulus
GO:0034774 secretory granule lumen
GO:0042802 identical protein binding
GO:0042866 pyruvate biosynthetic process
GO:0043312 neutrophil degranulation
GO:0043403 skeletal muscle tissue regeneration
GO:0043531 ADP binding
GO:0045296 cadherin binding
GO:0061621 canonical glycolysis
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0070324 thyroid hormone binding
GO:1902912 pyruvate kinase complex
GO:1903561 extracellular vesicle
GO:1903672 positive regulation of sprouting angiogenesis
GO:1904813 ficolin-1-rich granule lumen
GO:2000767 positive regulation of cytoplasmic translation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001697 Pyruvate kinaseFamilyFamily
IPR011037 Pyruvate kinase-like, insert domain superfamilyFamilyHomologous superfamily
IPR015793 Pyruvate kinase, barrelDomainDomain
IPR015795 Pyruvate kinase, C-terminalDomainDomain
IPR015806 Pyruvate kinase, insert domain superfamilyFamilyHomologous superfamily
IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain superfamilyFamilyHomologous superfamily
IPR018209 Pyruvate kinase, active siteSiteActive site
IPR036918 Pyruvate kinase, C-terminal domain superfamilyFamilyHomologous superfamily
IPR040442 Pyruvate kinase-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00119 Pyruvic acidDrugbanksmall molecule
DB00787 AcyclovirDrugbanksmall molecule
DB01733 L-PhospholactateDrugbanksmall molecule
DB02726 2-Phosphoglycolic AcidDrugbanksmall molecule
DB07628 6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-oneDrugbanksmall molecule
DB07692 1-[(2,6-difluorophenyl)sulfonyl]-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazineDrugbanksmall molecule
DB07697 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazineDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB11638 ArtenimolDrugbanksmall molecule

Interactions

98 interactions

InteractorPartnerSourcesPublicationsLink
KPYM_HUMANEXOS5_HUMANBioGRID, HPRD, IntAct15231747 details
KPYM_HUMANRAF1_HUMANBioGRID, HPRD, IntAct12620389 details
KPYM_HUMANARAF_HUMANBioGRID, HPRD, IntAct12620389 25241761 details
KPYM_HUMANNOE2_HUMANHPRD, IntAct16169070 details
KPYM_HUMANMDM2_HUMANBioGRID, IntAct20195357 27264869 details
KPYM_HUMANLMO7_HUMANBioGRID, IntAct21988832 details
KPYM_HUMANTF65_HUMANBioGRID, IntAct21988832 details
KPYM_HUMANPAX8_HUMANBioGRID, IntAct21988832 details
KPYM_HUMANHIF1A_HUMANBioGRID, IntAct21620138 details
KPYM_HUMANEGLN3_HUMANBioGRID, IntAct21620138 details
KPYM_HUMANANXA7_HUMANBioGRID, MINT21900206 details
KPYM_HUMANCDK4_HUMANBioGRID, MINT21900206 details
KPYM_HUMANCDN1A_HUMANBioGRID, MINT21900206 details
KPYM_HUMANGRB7_HUMANBioGRID, IntAct, MINT21900206 24606918 details
KPYM_HUMANNAGK_HUMANBioGRID, MINT21900206 details
KPYM_HUMANPIN1_HUMANBioGRID, MINT16055720 21900206 23178880 details
KPYM_HUMANRAP1B_HUMANBioGRID, MINT21900206 details
KPYM_HUMANRCC1_HUMANBioGRID, MINT21900206 details
KPYM_HUMANRPP14_HUMANBioGRID, MINT21900206 details
KPYM_HUMANSMN_HUMANBioGRID, MINT21900206 details
KPYM_HUMANKITH_HUMANBioGRID, MINT21900206 details
KPYM_HUMANENOB_HUMANBioGRID, IntAct22939629 23414517 details
KPYM_HUMANDAPK1_HUMANI2D21725354 details
KPYM_HUMANHD_HUMANIntAct17500595 32814053 details
KPYM_HUMANRHG07_HUMANBioGRID, MINT24412244 details
KPYM_HUMANH31_HUMANIntAct24606918 details
KPYM_HUMANMK03_HUMANIntAct24606918 details
KPYM_HUMANMPIP1_HUMANBioGRID, IntAct24606918 27485204 details
KPYM_HUMANFGFR1_HUMANBioGRID, IntAct24606918 25263439 32572027 details
KPYM_HUMANFGFR3_HUMANIntAct24606918 32814053 details
KPYM_HUMANTERF1_HUMANbhf-ucl, BioGRID21044950 details
KPYM_HUMANTINF2_HUMANbhf-ucl, BioGRID21044950 details
KPYM_HUMANDUX4_HUMANBioGRID, IntAct26816005 details
KPYM_HUMANCTNB1_HUMANBioGRID, DIP22056988 27485204 27684187 29463646 details
KPYM_HUMANKPYM_HUMANBioGRID, DIP, HPRD11960989 23064226 24344305 2813362 details
KPYM_HUMANSAV1_HUMANIntAct22570112 details
KPYM_HUMANCCR4_HUMANBioGRID, MINT28298427 details
KPYM_HUMANPRKN_HUMANBioGRID, UniProt25959826 26975375 32929329 details
KPYM_HUMANZP2_HUMANIntAct23355646 details
KPYM_HUMANZP3_HUMANIntAct23355646 details
KPYM_HUMANZP4_HUMANIntAct23355646 details
KPYM_HUMANTRI63_HUMANBioGRID, HPRD, IntAct15967462 18468620 31391242 details
KPYM_HUMANTRI55_HUMANBioGRID, IntAct31391242 details
KPYM_HUMANBOD1_HUMANIntAct32814053 details
KPYM_HUMANRYBP_HUMANIntAct32814053 details
KPYM_HUMANUBQL1_HUMANIntAct32814053 details
KPYM_HUMANSPRE1_HUMANIntAct32814053 details
KPYM_HUMANHERC1_HUMANBioGRID, HPRD12650930 details
KPYM_HUMANUCHL5_HUMANBioGRID21800051 details
KPYM_HUMANSHBG_HUMANBioGRID, HPRD15862967 details
KPYM_HUMANMYOC_HUMANBioGRID16289162 details
KPYM_HUMANA4_HUMANBioGRID21832049 details
KPYM_HUMANHS90A_HUMANBioGRID16263121 31273033 details
KPYM_HUMAN1433T_HUMANBioGRID15161933 details
KPYM_HUMANDPOE2_HUMANBioGRID25416956 details
KPYM_HUMANNXT2_HUMANBioGRID25416956 details
KPYM_HUMANLNX1_HUMANBioGRID25416956 details
KPYM_HUMANSUMO1_HUMANBioGRID12565818 details
KPYM_HUMANPTEN_HUMANBioGRID26561776 details
KPYM_HUMANTRI35_HUMANBioGRID25263439 details
KPYM_HUMANUBP7_HUMANBioGRID25695607 32545446 details
KPYM_HUMANEPM2A_HUMANBioGRID26493215 details
KPYM_HUMANMLRV_HUMANBioGRID25412762 details
KPYM_HUMANAURKB_HUMANBioGRID25412762 details
KPYM_HUMANMK01_HUMANBioGRID23178880 details
KPYM_HUMANIMA5_HUMANBioGRID23178880 details
KPYM_HUMANKDM8_HUMANBioGRID24344305 details
KPYM_HUMANSUMO2_HUMANBioGRID32786267 details
KPYM_HUMANUBE3A_HUMANBioGRID31329371 details
KPYM_HUMANOGT1_HUMANBioGRID32994395 details
KPYM_HUMAN1433Z_HUMANMINT15161933 details
KPYM_HUMANARRB1_HUMANBioGRID, IntAct17620599 details
KPYM_HUMANARRB2_HUMANBioGRID, IntAct17620599 details
KPYM_HUMANEGLN1_HUMANBioGRID, IntAct21620138 details
KPYM_HUMANEPAS1_HUMANIntAct21620138 details
KPYM_HUMANEP300_HUMANBioGRID, IntAct21620138 details
KPYM_HUMANBIN1_HUMANIntAct24606918 31413325 details
KPYM_HUMANHDAC3_HUMANDIP22056988 details
KPYM_HUMANDISC1_HUMANIntAct31413325 details
KPYM_HUMANARX_HUMANMINT21653829 details
KPYM_HUMANFXR1_HUMANMINT21653829 details
KPYM_HUMANFXR2_HUMANMINT21653829 details
KPYM_HUMANHXA1_HUMANMINT21653829 details
KPYM_HUMANBAF_HUMANBioGRID19759913 details
KPYM_HUMANMGMT_HUMANBioGRID16226712 details
KPYM_HUMANHDAC5_HUMANBioGRID21081666 details
KPYM_HUMANISG15_HUMANBioGRID16009940 33024031 details
KPYM_HUMANPML_HUMANBioGRID18298799 details
KPYM_HUMANELP1_HUMANBioGRID18303054 details
KPYM_HUMAN3MG_HUMANBioGRID23537643 details
KPYM_HUMANHDAC6_HUMANBioGRID23703321 26643866 29278704 details
KPYM_HUMANDDB2_HUMANBioGRID26410533 details
KPYM_HUMANU2AF2_HUMANBioGRID26641092 details
KPYM_HUMANHELLS_HUMANBioGRID31594538 details
KPYM_HUMANP53_HUMANBioGRID31594538 32807901 details
KPYM_HUMANTRI58_HUMANBioGRID32219144 details
KPYM_HUMANCD47_HUMANBioGRID29463646 details
KPYM_HUMANSRBS2_HUMANHPRD15128873 details