Entity Details

Primary name CSF2R_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP15509
EntryNameCSF2R_HUMAN
FullNameGranulocyte-macrophage colony-stimulating factor receptor subunit alpha
TaxID9606
Evidenceevidence at protein level
Length400
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesCSF2RA

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0004896 cytokine receptor activity
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0019955 cytokine binding
GO:0038023 signaling receptor activity
GO:0043235 receptor complex
GO:0044267 cellular protein metabolic process

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR003532 Short hematopoietin receptor, family 2, conserved siteSiteConserved site
IPR003961 Fibronectin type IIIDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015321 Type I cytokine receptor, cytokine-binding domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR040907 IL-3 receptor alpha chain, N-terminalDomainDomain

Diseases

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Disease IDSourceNameDescription
300770 OMIMPulmonary surfactant metabolism dysfunction 4 (SMDP4)A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00020 SargramostimDrugbankbiotech
DB05194 KB002Drugbanksmall molecule
DB05386 RegramostimDrugbankbiotech
DB10770 Foreskin fibroblast (neonatal)Drugbankbiotech
DB10772 Foreskin keratinocyte (neonatal)Drugbankbiotech
DB11338 Clove oilDrugbankbiotech