Entity Details

Primary name LOX15_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP16050
EntryNameLOX15_HUMAN
FullNamePolyunsaturated fatty acid lipoxygenase ALOX15
TaxID9606
Evidenceevidence at protein level
Length662
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesALOX15

GO terms

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GOName
GO:0001503 ossification
GO:0002820 negative regulation of adaptive immune response
GO:0004052 arachidonate 12(S)-lipoxygenase activity
GO:0005506 iron ion binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005811 lipid droplet
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006629 lipid metabolic process
GO:0006646 phosphatidylethanolamine biosynthetic process
GO:0006691 leukotriene metabolic process
GO:0006954 inflammatory response
GO:0010811 positive regulation of cell-substrate adhesion
GO:0016020 membrane
GO:0016165 linoleate 13S-lipoxygenase activity
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0019221 cytokine-mediated signaling pathway
GO:0019369 arachidonic acid metabolic process
GO:0019372 lipoxygenase pathway
GO:0019395 fatty acid oxidation
GO:0030282 bone mineralization
GO:0030838 positive regulation of actin filament polymerization
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0034116 positive regulation of heterotypic cell-cell adhesion
GO:0034440 lipid oxidation
GO:0034976 response to endoplasmic reticulum stress
GO:0035358 regulation of peroxisome proliferator activated receptor signaling pathway
GO:0035963 cellular response to interleukin-13
GO:0042060 wound healing
GO:0042759 long-chain fatty acid biosynthetic process
GO:0043277 apoptotic cell clearance
GO:0043651 linoleic acid metabolic process
GO:0047977 hepoxilin-epoxide hydrolase activity
GO:0050473 arachidonate 15-lipoxygenase activity
GO:0050727 regulation of inflammatory response
GO:0051120 hepoxilin A3 synthase activity
GO:0051122 hepoxilin biosynthetic process
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071277 cellular response to calcium ion
GO:1901074 regulation of engulfment of apoptotic cell
GO:2001303 lipoxin A4 biosynthetic process

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Lipid droplet

Domains

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DomainNameCategoryType
IPR000907 LipoxygenaseFamilyFamily
IPR001024 PLAT/LH2 domainDomainDomain
IPR001885 Lipoxygenase, mammalianFamilyFamily
IPR013819 Lipoxygenase, C-terminalDomainDomain
IPR020833 Lipoxygenase, iron binding siteSiteBinding site
IPR020834 Lipoxygenase, conserved siteSiteConserved site
IPR036226 Lipoxigenase, C-terminal domain superfamilyFamilyHomologous superfamily
IPR036392 PLAT/LH2 domain superfamilyFamilyHomologous superfamily
IPR042062 Lipoxygenase, vertebrates, PLAT domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB02709 ResveratrolDrugbanksmall molecule
DB08492 (2E)-3-(2-OCT-1-YN-1-YLPHENYL)ACRYLIC ACIDDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
LOX15_HUMANPEBP1_HUMANBioGRID, DIP21831839 details
LOX15_HUMANPRKDC_HUMANBioGRID18785202 details