Entity Details

Primary name XBP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP17861
EntryNameXBP1_HUMAN
FullNameX-box-binding protein 1
TaxID9606
Evidenceevidence at protein level
Length261
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesXBP1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001525 angiogenesis
GO:0001558 regulation of cell growth
GO:0001889 liver development
GO:0001934 positive regulation of protein phosphorylation
GO:0001935 endothelial cell proliferation
GO:0002020 protease binding
GO:0002639 positive regulation of immunoglobulin production
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0006366 transcription by RNA polymerase II
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006914 autophagy
GO:0006915 apoptotic process
GO:0006955 immune response
GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
GO:0006996 organelle organization
GO:0007517 muscle organ development
GO:0008284 positive regulation of cell population proliferation
GO:0010508 positive regulation of autophagy
GO:0010832 negative regulation of myotube differentiation
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0015031 protein transport
GO:0016021 integral component of membrane
GO:0019901 protein kinase binding
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0030331 estrogen receptor binding
GO:0030335 positive regulation of cell migration
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031062 positive regulation of histone methylation
GO:0031490 chromatin DNA binding
GO:0031625 ubiquitin protein ligase binding
GO:0031647 regulation of protein stability
GO:0031648 protein destabilization
GO:0031670 cellular response to nutrient
GO:0032008 positive regulation of TOR signaling
GO:0032755 positive regulation of interleukin-6 production
GO:0032869 cellular response to insulin stimulus
GO:0034599 cellular response to oxidative stress
GO:0034976 response to endoplasmic reticulum stress
GO:0035356 cellular triglyceride homeostasis
GO:0035470 positive regulation of vascular wound healing
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0036498 IRE1-mediated unfolded protein response
GO:0036500 ATF6-mediated unfolded protein response
GO:0042149 cellular response to glucose starvation
GO:0042307 positive regulation of protein import into nucleus
GO:0042632 cholesterol homeostasis
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045579 positive regulation of B cell differentiation
GO:0045582 positive regulation of T cell differentiation
GO:0045600 positive regulation of fat cell differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046982 protein heterodimerization activity
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048666 neuron development
GO:0051897 positive regulation of protein kinase B signaling
GO:0055089 fatty acid homeostasis
GO:0055092 sterol homeostasis
GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0060612 adipose tissue development
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0071073 positive regulation of phospholipid biosynthetic process
GO:0071222 cellular response to lipopolysaccharide
GO:0071230 cellular response to amino acid stimulus
GO:0071332 cellular response to fructose stimulus
GO:0071333 cellular response to glucose stimulus
GO:0071353 cellular response to interleukin-4
GO:0071375 cellular response to peptide hormone stimulus
GO:0071498 cellular response to fluid shear stress
GO:0071499 cellular response to laminar fluid shear stress
GO:1900100 positive regulation of plasma cell differentiation
GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response
GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response
GO:1901985 positive regulation of protein acetylation
GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:1903489 positive regulation of lactation
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1904754 positive regulation of vascular associated smooth muscle cell migration
GO:1990418 response to insulin-like growth factor stimulus
GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000347 positive regulation of hepatocyte proliferation
GO:2000353 positive regulation of endothelial cell apoptotic process

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum
Endoplasmic reticulum membrane
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR004827 Basic-leucine zipper domainDomainDomain

Diseases

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Interactions

39 interactions

InteractorPartnerSourcesPublicationsLink
XBP1_HUMANXBP1_HUMANBioGRID, HPIDb, HPRD, MINT, UniProt12805554 20102225 23661758 25239945 details
XBP1_HUMANPSA5_HUMANBioGRID, MINT19941857 details
XBP1_HUMANPSA6_HUMANBioGRID, MINT19941857 details
XBP1_HUMANPSA7_HUMANMINT19941857 details
XBP1_HUMANATF6A_HUMANBioGRID, HPIDb, UniProt20102225 23661758 details
XBP1_HUMANZHANG_HUMANBioGRID, HPIDb, UniProt20102225 23661758 details
XBP1_HUMANMTR1B_HUMANBioGRID, IntAct26514267 details
XBP1_HUMANUB2V1_HUMANBioGRID, IntAct32296183 details
XBP1_HUMANATF6B_HUMANBioGRID, UniProt23661758 details
XBP1_HUMANZN440_HUMANBioGRID, IntAct20211142 details
XBP1_HUMANZN580_HUMANBioGRID, IntAct20211142 details
XBP1_HUMANSSX4_HUMANBioGRID, IntAct20211142 details
XBP1_HUMANSRSF1_HUMANBioGRID, IntAct20211142 details
XBP1_HUMANRBL2_HUMANBioGRID, IntAct20211142 details
XBP1_HUMANHDGF_HUMANBioGRID, IntAct20211142 details
XBP1_HUMANH10_HUMANBioGRID, IntAct20211142 details
XBP1_HUMANGLI1_HUMANBioGRID, IntAct20211142 details
XBP1_HUMANNR0B2_HUMANBioGRID, IntAct20211142 details
XBP1_HUMANPHS2_HUMANBioGRID, IntAct20211142 details
XBP1_HUMANH1X_HUMANBioGRID, IntAct20211142 details
XBP1_HUMANFUBP3_HUMANBioGRID, IntAct20211142 details
XBP1_HUMANTRIP4_HUMANBioGRID, IntAct20211142 details
XBP1_HUMANESR1_HUMANBioGRID, HPRD12954762 details
XBP1_HUMANFOS_HUMANBioGRID, HPRD1903538 details
XBP1_HUMANUBC9_HUMANBioGRID23470653 details
XBP1_HUMANMDM2_HUMANBioGRID29057323 details
XBP1_HUMANVIME_HUMANMINT19941857 details
XBP1_HUMANHM13_HUMANBioGRID, MINT25239945 details
XBP1_HUMANRN139_HUMANMINT25239945 details
XBP1_HUMANDERL1_HUMANBioGRID, MINT25239945 details
XBP1_HUMANCALX_HUMANMINT25239945 details
XBP1_HUMANHIF1A_HUMANDIP24670641 details
XBP1_HUMANPSMA8_HUMANBioGRID19941857 details
XBP1_HUMANKAT2B_HUMANBioGRID25426559 details
XBP1_HUMANKAT2A_HUMANBioGRID25426559 details
XBP1_HUMANFBXW7_HUMANBioGRID30783083 details
XBP1_HUMANNFYA_HUMANBioGRID31387940 details
XBP1_HUMANNFYB_HUMANBioGRID31387940 details
XBP1_HUMANNFYC_HUMANBioGRID31387940 details